Chemical and biological characterization of sulfated chitosan oligomer as heparin mimics

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dc.authoridAkkaya, Birnur/0000-0001-9139-1884
dc.authoridBahar, Mehmet Refik/0000-0002-7922-3850
dc.authoridAKKAYA, Recep/0000-0002-3477-7198
dc.authorwosidkocabay, samet/HZI-2537-2023
dc.authorwosidAkkaya, Birnur/AAZ-2285-2021
dc.authorwosidBahar, Mehmet Refik/ABI-6343-2020
dc.authorwosidAKKAYA, Recep/JYQ-3788-2024
dc.contributor.authorKocabay, Samet
dc.contributor.authorBahar, Mehmet Refik
dc.contributor.authorTekin, Suat
dc.contributor.authorAkkaya, Recep
dc.contributor.authorAkkaya, Birnur
dc.date.accessioned2024-08-04T20:50:33Z
dc.date.available2024-08-04T20:50:33Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, chitosan oligomer was modified to sulfated chitosan oligomer (ShCsO) to mimic heparin. Its chemical structure was determined by infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and thermogravimetric analysis. The results showed that the FT-IR spectrum band at 799 cm(-1) corresponds to C-O-S and that at 1212 cm(-1) corresponds to S=O bond stretching, which prove that the sulfate groups are incorporated into chitosan oligomer successfully. The antimicrobial activity of ShCsO against to Bacillus subtilis in 1% concentration was 89.1 +/- 1.7%. The IC50 (mu g/ml) of ShCsO was 67.75, 56.07, 85.47, and 84.68 for A2780, MCF-7, DU-145, and HepG2, respectively. The results show that this newly synthesized material is a potential candidate to heparin-like chitosan derivatives. According to the literature, it was the first time that chitosan oligomer was modified to mimic heparin.en_US
dc.description.sponsorshipCumhuriyet University Scientific Research Project (CUBAP) [F-575]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Cumhuriyet University Scientific Research Project (CUBAP) financed this project (Project number:F-575).en_US
dc.identifier.doi10.1177/09673911211035068
dc.identifier.endpageS1032en_US
dc.identifier.issn0967-3911
dc.identifier.issn1478-2391
dc.identifier.issue9_SUPPLen_US
dc.identifier.scopus2-s2.0-85112463209en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageS1023en_US
dc.identifier.urihttps://doi.org/10.1177/09673911211035068
dc.identifier.urihttps://hdl.handle.net/11616/100126
dc.identifier.volume29en_US
dc.identifier.wosWOS:000685542300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofPolymers & Polymer Compositesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantimicrobialen_US
dc.subjectchitosan oligomeren_US
dc.subjectcytotoxicityen_US
dc.subjectheparinen_US
dc.subjectmetastasisen_US
dc.titleChemical and biological characterization of sulfated chitosan oligomer as heparin mimicsen_US
dc.typeArticleen_US

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