Serum erythropoietin levels in patients with leukemia on cytostatic treatment

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dc.authoridBeksac, Meral/0000-0003-1797-8657
dc.authorwosidBeksac, Meral/D-6411-2013
dc.contributor.authorAydogdu, I
dc.contributor.authorIlhan, O
dc.contributor.authorBeksac, M
dc.contributor.authorKoc, H
dc.contributor.authorAkan, H
dc.contributor.authorKonuk, N
dc.contributor.authorUysal, A
dc.date.accessioned2024-08-04T20:11:58Z
dc.date.available2024-08-04T20:11:58Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAnemia is the major stimulus for erythropoietin (Epo) secretion. Various studies have reported increase of Epo following chemotherapy. The mechanism of this phenomenon is not yet clarified. In this study, the serum Epo levels have been evaluated before, during (7 and 14 days), and after (day 25) chemotherapy in patients with acute myeloblastic leukemia (n = 13) and lymphoblastic leukemia (n = 4). As a control group. 12 healthy age-matched subjects were evaluated. Epo levels were high in untreated leukemia patients compared to controls and continued Lo increase following chemotherapy. There was no significant difference in post-treatment values of Epo as compared with pre-treatment levels. In patients with pre-treatment values of Hb less than or equal to 9 g/dl, Epo levels were inversely correlated with Hb (r = 0.552; p < 0.05). This correlation disappeared during and following treatment. There was no correlation between Epo levels and hematological or biochemical parameters. Therefore, elevated levels of Epo regardless of anemia may be due to a response to tissue hypoxia or increased synthesis of Epo in liver or bone marrow.en_US
dc.identifier.endpage137en_US
dc.identifier.issn0017-6559
dc.identifier.issue2en_US
dc.identifier.pmid9728805en_US
dc.identifier.scopus2-s2.0-0031825146en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://hdl.handle.net/11616/93113
dc.identifier.volume29en_US
dc.identifier.wosWOS:000075465200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVsp Bven_US
dc.relation.ispartofHaematologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecterythropoietinen_US
dc.subjectleukemiaen_US
dc.subjectchemotherapyen_US
dc.titleSerum erythropoietin levels in patients with leukemia on cytostatic treatmenten_US
dc.typeArticleen_US

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