Aminoguanidine mitigates apoptosis, testicular seminiferous tubules damage, and oxidative stress in streptozotocin-induced diabetic rats

Basit Öğe Kaydı
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridTaslidere, Elif/0000-0003-1723-2556;
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidElbe, Hulya/D-5261-2015
dc.contributor.authorOrman, Dogan
dc.contributor.authorVardi, Nigar
dc.contributor.authorAtes, Burhan
dc.contributor.authorTaslidere, Elif
dc.contributor.authorElbe, Hulya
dc.date.accessioned2024-08-04T20:40:17Z
dc.date.available2024-08-04T20:40:17Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study aimed to investigate the effect of aminoguanidine (AG) against testicular damage streptozotocin (STZ) induced diabetes. Thirty two rats were separated into four groups: control, AG, STZ and STZ + AG. In the STZ group, 12.5 +/- 1.3% of tubules were seen as containing sloughed spermatogenic cells into the lumen, 28.7 +/- 1.8% of tubules were atrophic, 46.2 +/- 2.1% of tubules were degenerative and 8.5 +/- 0.9% of tubules contained giant cells. Statistically, the affected tubule number was significantly lower in the STZ + AG group than in the STZ group. Intensely stained caspase-3 cells showed a statistically significant increase in the STZ group, while it decreased in the STZ + AG group. The enzyme activities of catalase (CAT), superoxide dismutase (SOD) and glutathione (GSH) level decreased and the level of malondialdehyde (MDA) and nitric oxide (NO) increased in the STZ group, while AG treated diabetic rats showed an increase of CAT, SOD activity and GSH level and a decrease in MDA and NO levels. This study shows that the oxidative stress, increased NO level and apoptotic cell death play an important role in diabetic rat testicular damage and that AG treatment of diabetic rats results in protection of spermatogenic cells against oxidative stress and apoptotic cell death. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific Research Fund of Inonu University [2009/47]en_US
dc.description.sponsorshipThe authors wish to express their thanks to Prof. Dr. Saim Yologlu for his helps in statistical analyses. This study was supported by a Grant from Scientific Research Fund of Inonu University (Project number: 2009/47).en_US
dc.identifier.doi10.1016/j.tice.2015.03.006
dc.identifier.endpage290en_US
dc.identifier.issn0040-8166
dc.identifier.issue3en_US
dc.identifier.pmid25862575en_US
dc.identifier.scopus2-s2.0-84930090529en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage284en_US
dc.identifier.urihttps://doi.org/10.1016/j.tice.2015.03.006
dc.identifier.urihttps://hdl.handle.net/11616/96801
dc.identifier.volume47en_US
dc.identifier.wosWOS:000355557700008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofTissue & Cellen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAminoguanidineen_US
dc.subjectDiabetesen_US
dc.subjectNitric oxideen_US
dc.subjectRaten_US
dc.subjectTestisen_US
dc.titleAminoguanidine mitigates apoptosis, testicular seminiferous tubules damage, and oxidative stress in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu