Effects of sevoflurane or ketamine on the QTc interval during electroconvulsive therapy

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dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridErdil, Feray Akgül/0000-0002-7544-3717
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridErdogan Kayhan, Gulay/0000-0002-2635-9295
dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidErdil, Feray Akgül/ABI-2474-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidErdogan Kayhan, Gulay/JVZ-0037-2024
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.contributor.authorErdil, Feray
dc.contributor.authorBegec, Zekine
dc.contributor.authorKayhan, Gulay Erdogan
dc.contributor.authorYologlu, Saim
dc.contributor.authorErsoy, Mehmet Ozcan
dc.contributor.authorDurmus, Mahmut
dc.date.accessioned2024-08-04T20:40:17Z
dc.date.available2024-08-04T20:40:17Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo evaluate the effect of sevoflurane or ketamine on the corrected QT (QTc) interval and the interval from the peak to the end of the T wave (Tp-e) during electroconvulsive therapy (ECT) in patients with major depression. This prospective, randomized, double-blinded study included 24 patients that were randomly allocated to receive sevoflurane (group S) or ketamine (group K) for ECT session. Group S patients received 8 % sevoflurane for anesthesia induction, which was maintained at 2-4 % until delivery of the electrical stimulus. Group K patients received a bolus of ketamine (1 mg/kg). The mean arterial pressure (MAP) and heart rate (HR) and the electrocardiogram (ECG) were recorded before (T1) and after induction of anesthesia (T2) and 0, 1, 3, and 10 min after the electrical stimuli ended (T3, T4, T5, and T6, respectively). In both groups, the QTc interval was significantly longer at T2, T4, T5, and T6 than at baseline. The QTc interval was longer at T4, T5, and T6 in group S compared to that in group K, the Tp-e interval was significantly longer at T4 in group K both baseline and group S. The HR in group S was increased at T4 compared with group K. MAP was significantly higher after induction of anesthesia in group K compared to those in group S at all time points. Although group S showed a prolonged QTc interval after ECT compared to group K, the Tp-e interval in both groups was not significantly affected clinically. Sevoflurane blunted MAP and peak HR.en_US
dc.identifier.doi10.1007/s00540-014-1899-2
dc.identifier.endpage185en_US
dc.identifier.issn0913-8668
dc.identifier.issn1438-8359
dc.identifier.issue2en_US
dc.identifier.pmid25085036en_US
dc.identifier.scopus2-s2.0-84930739439en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage180en_US
dc.identifier.urihttps://doi.org/10.1007/s00540-014-1899-2
dc.identifier.urihttps://hdl.handle.net/11616/96816
dc.identifier.volume29en_US
dc.identifier.wosWOS:000352859100005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofJournal of Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectroconvulsive therapyen_US
dc.subjectKetamineen_US
dc.subjectMajor depressionen_US
dc.subjectSevofluraneen_US
dc.subjectQTc intervalen_US
dc.titleEffects of sevoflurane or ketamine on the QTc interval during electroconvulsive therapyen_US
dc.typeArticleen_US

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