Effects of dexpanthenol on acetic acid-induced colitis in rats

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authoridATAYAN, Yahya/0000-0003-2076-1934
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridATAYAN, YAHYA/0000-0003-2076-1934
dc.authoriderdogan, mehmet ali/0000-0002-1713-5695
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidCagin, Yasir Furkan/ABI-2709-2020
dc.authorwosidATAYAN, Yahya/O-3527-2018
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidATAYAN, YAHYA/KXQ-8881-2024
dc.authorwosiderdogan, mehmet ali/ABI-4675-2020
dc.contributor.authorCagin, Yasir Furkan
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorVardi, Nigar
dc.contributor.authorPolat, Alaadin
dc.contributor.authorAtayan, Yahya
dc.contributor.authorErdogan, Mehmet Ali
dc.contributor.authorTanbek, Kevser
dc.date.accessioned2024-08-04T20:42:42Z
dc.date.available2024-08-04T20:42:42Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWhile the pathogenesis of acetic acid (AA)-induced colitis is unclear, reactive oxygen species are considered to have a significant effect. The aim of the present study was to elucidate the therapeutic potential of dexpanthenol (Dxp) on the amelioration of colitis in rats. Group I (n=8; control group) was intrarectally administered 1 ml saline solution (0.9%); group II [n=8; AA] was administered 4% AA into the colon via the rectum as a single dose for three consecutive days; group III (n=8; AA + Dxp) was administered AA at the same dosage as group II from day 4, and a single dose of Dxp was administered intraperitoneally; and group IV (n=8; Dxp) was administered Dxp similarly to Group III. Oxidative stress and colonic damage were assessed via biochemical and histologic examination methods. AA treatment led to an increase in oxidative parameters and a decrease in antioxidant systems. Histopathological examination showed that AA treatment caused tissue injury and increased caspase-3 activity in the distal colon and triggered apoptosis. Dxp treatment caused biochemical and histopathological improvements, indicating that Dxp may have an anti-oxidant effect in colitis; therefore, Dxp may be a potential therapeutic agent for the amelioration of IBD.en_US
dc.identifier.doi10.3892/etm.2016.3728
dc.identifier.endpage2964en_US
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.issue5en_US
dc.identifier.pmid27882101en_US
dc.identifier.scopus2-s2.0-84991704668en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2958en_US
dc.identifier.urihttps://doi.org/10.3892/etm.2016.3728
dc.identifier.urihttps://hdl.handle.net/11616/97538
dc.identifier.volume12en_US
dc.identifier.wosWOS:000388822000025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpandidos Publ Ltden_US
dc.relation.ispartofExperimental and Therapeutic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdexpanthenolen_US
dc.subjectacetic aciden_US
dc.subjectcolonen_US
dc.subjectoxidative stressen_US
dc.titleEffects of dexpanthenol on acetic acid-induced colitis in ratsen_US
dc.typeArticleen_US

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