ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET

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dc.contributor.authorGencer, Ayşe
dc.contributor.authorAkgeyik, Emrah
dc.contributor.authorKaynak, Mustafa Sinan
dc.contributor.authorÇelebier, Mustafa
dc.contributor.authorBerkman, Murat Sami
dc.contributor.authorŞahin, Selma
dc.date.accessioned2021-03-21T09:22:17Z
dc.date.available2021-03-21T09:22:17Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract: Cardioselective ?-adrenergic blocker metoprolol tartrate, is used in the treatment of different diseases such as cardiac arrhythmias, hypertension, heart failure, angina pectoris, migraine, and hyperthyroidism. Beside dosage forms of the parenteral ampoule and conventional tablets of different manufacturers, there are extended release tablets of metoprolol tartrate in the Turkish Drug Market. In this research work, comparative quality control studies of metoprolol tartrate extended release tablets (original and generic) produced by two different pharmaceutical companies in the Turkey were carried out and evaluated according to the related guidelines. Thickness and diameter, hardness, weight variation, friability, content uniformity and dissolution rate were examined as quality control parameters. A new validated HPLC method for the quantification of metoprolol tartrate has been developed. An ACE column (C18, 5 µm, 250x4.6 mm) and acetonitrile: phosphate buffer (30: 70, v/v) mobile phase were used for the determination of metoprolol tartrate. The tablets showed extended release for 8 hours (70.74% release from drug A, 76.87% from the drug B). Both products have acceptable hardness, friability and weight variation values. Content of the active ingredient of the tablets was consistent with label claim (99.45% for drug A and 96.45% for drug B). The dissolution data were evaluated by model dependent and model independent methods using DDSolver program. The obtained results showed that release kinetics of both drugs were well fitted with the Korsmeyer-Peppas model.en_US
dc.identifier.citationGENCER A,AKGEYİK E,KAYNAK M. S,ÇELEBİER M,BERKMAN M. S,ŞAHİN S (2020). ASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKET. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online), 9(2), 179 - 189. Doi: 10.18036/estubtdc.661691en_US
dc.identifier.doi10.18036/estubtdc.661691en_US
dc.identifier.endpage189en_US
dc.identifier.issn2667-4203
dc.identifier.issue2en_US
dc.identifier.startpage179en_US
dc.identifier.trdizinid390561en_US
dc.identifier.urihttps://doi.org/10.18036/estubtdc.661691
dc.identifier.urihttps://hdl.handle.net/11616/19651
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/390561
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofEskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleASSESSMENT OF PHARMACEUTICAL QUALITY AND RELEASE KINETICS OF METOPROLOL TARTRATE EXTENDED RELEASE TABLETS AVAILABLE IN TURKISH DRUG MARKETen_US
dc.typeArticleen_US

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