Analyzing Spinal Cord Stimulation With Different Electrode Configurations: A Numerical Study

Basit Öğe Kaydı
dc.contributor.authorAydin, Elif Feyza
dc.contributor.authorZengln, Reyhan
dc.date.accessioned2026-04-04T13:37:41Z
dc.date.available2026-04-04T13:37:41Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractSpinal cord stimulation (SCS) represents a therapeutic approach for chronic pain management in patients refractory to conventional treatments. By implanting electrodes in the epidural space, SCS aims to mitigate pain transmission to the brain through electrical stimulation, often resulting in sensory perceptions such as paresthesia. This study investigates the influence of electrode configurations on electrical parameters, including current density and electric potential, within the spinal cord environment. Utilizing computational models of the spinal canal incorporating components such as epidural fat, cerebrospinal fluid (CSF), gray matter, and white matter, our analysis explores the distribution of electric potential and current density. Specifically, configurations employing four and nine electrodes are evaluated under both direct current (DC) and alternating current (AC) stimulations. For DC stimulations at currents of 1, 5, and 10 mA, our findings indicate that the four-electrode model generated current density values in epidural fat ranging from 107.90 to 130.98 mA/cm2 and electric potential values ranging from 3.51 to 4.78 V. Similarly, the nine-electrode model produced current density values ranging from 92.51 to 223.61 mA/cm2 and electric potential values ranging from 1.27 to 7.83 V under the same conditions. The results demonstrate a proportional relationship between applied current, current density, and electric potential. Furthermore, our investigation reveals a gradual decrease in electrical potential and current density from the epidural space to the gray matter. Discussions encompass the safety implications of these findings, examining whether the observed electrical parameters remain within tolerable limits for patient well-being. Additionally, the study explores the effects of AC stimulation across frequencies ranging from 250 Hz to 10 kHz, revealing an inverse correlation between frequency and charge parameters. Specifically, higher frequencies corresponded to reduced charge per phase and charge density, underscoring the frequency-dependent nature of these electrical properties.
dc.identifier.doi10.1002/cnm.3894
dc.identifier.issn2040-7939
dc.identifier.issn2040-7947
dc.identifier.issue1
dc.identifier.orcid0000-0001-8631-3339
dc.identifier.pmid39704697
dc.identifier.scopus2-s2.0-85212583146
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/cnm.3894
dc.identifier.urihttps://hdl.handle.net/11616/109989
dc.identifier.volume41
dc.identifier.wosWOS:001396221500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal For Numerical Methods in Biomedical Engineering
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectcurrent density
dc.subjectelectrode
dc.subjectneuromodulation
dc.subjectnumerical analysis
dc.subjectspinal cord stimulation
dc.titleAnalyzing Spinal Cord Stimulation With Different Electrode Configurations: A Numerical Study
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu