Investigation of the Effect of Astaxanthin on Autophagy in Renal Ischemia-reperfusion Modeled Rats

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dc.authorscopusid57222366532
dc.authorscopusid17135127300
dc.authorscopusid57200071682
dc.authorscopusid55329785600
dc.authorscopusid55890995200
dc.authorscopusid55966963000
dc.authorscopusid57216689397
dc.contributor.authorKisaoglu A.
dc.contributor.authorKose E.
dc.contributor.authorYilmaz N.
dc.contributor.authorTanbek K.
dc.contributor.authorYildiz A.
dc.contributor.authorYilmaz U.
dc.contributor.authorCirik R.H.
dc.date.accessioned2024-08-04T20:03:35Z
dc.date.available2024-08-04T20:03:35Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the effect of various astaxanthin (ATX) doses on oxidative damage and autophagy in renal ischemia-reperfusion (I/R) injury-modeled rats. Methods: The rats were divided into five groups: sham group (n=8), I/R (n=8), I/R + 5 mg/kg ATX (n=8), I/R + 10 mg/kg ATX (n=8), and I/R + 25 mg/ kg ATX (n=8) groups. ATX was dissolved in 5 mg/kg, 10 mg/kg, and 25 mg/ kg olive oil for 7 days and administered to the rats in the experimental group. Sham and I/R groups were also administered ATX solution (olive oil) via oral gavage for 7 days. Renal ischemia reperfusion was induced in all rats except the sham group after the last dose was administered on the 7th day. Reperfusion was conducted for 24 hours after 45 minutes of ischemia. Results: Blood samples were collected, and kidney tissue were incised for biochemical and histological analyses. Superoxide dismutase (SOD) and total antioxidant status (TAS) were significantly lower in the I/R group than in the sham group (p<0.05), whereas malondialdehyde (MDA) and total oxidant status (TOS) values were higher (p<0.05). It was determined that SOD and TAS increased and MDA and TOS decreased in the ATX-administration groups compared with the I/R group, independent of the dose (p<0.05). In the 25 mg/kg ATX + I/R group, Beclin-1 and LC3? immunoreactivities were significantly higher than those in the other groups (p<0.05). The lowest p62 immunoreactivity was observed in the 25 mg/kg ATX + I/R group. Conclusions: ATX had a protective effect on kidney function and against oxidative damage. Furthermore, high-dose ATX administration protected kidney tissue via autophagy induction in this study. © 2024 The Author.en_US
dc.description.sponsorshipTYL-2020-2009en_US
dc.description.sponsorshipthe Research Fund of Inonu University, Project No: TYL-2020-2009.en_US
dc.identifier.doi10.4274/MMJ.galenos.2024.27243
dc.identifier.endpage108en_US
dc.identifier.issn2149-2042
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85197874884en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://doi.org/10.4274/MMJ.galenos.2024.27243
dc.identifier.urihttps://hdl.handle.net/11616/91937
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Publishing Houseen_US
dc.relation.ispartofMedeniyet Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAstaxanthinen_US
dc.subjectautophagyen_US
dc.subjectischemia/reperfusionen_US
dc.subjectoxidative stressen_US
dc.subjectrenalen_US
dc.titleInvestigation of the Effect of Astaxanthin on Autophagy in Renal Ischemia-reperfusion Modeled Ratsen_US
dc.title.alternativeBöbrek İskemi-reperfüzyon Modeli Oluşturulan Sıçanlarda Astaksantinin Otofaji Üzerine Etkisinin Araştırılmasıen_US
dc.typeArticleen_US

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