Comparative evaluation of the sexual functions and NF-?B and Nrf2 pathways of some aphrodisiac herbal extracts in male rats

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dc.authoridOrhan, Cemal/0000-0003-4138-7689
dc.authoridAkdemir, Fatih/0000-0002-5779-6631
dc.authoridYilmaz, Ismet/0000-0001-8680-3098
dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authoridGENCOGLU, HASAN/0000-0002-7716-552X
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridsahin, nurhan/0000-0001-9487-1154
dc.authorwosidOrhan, Cemal/Q-2086-2015
dc.authorwosidTürk, Gaffari/V-6922-2018
dc.authorwosidSahin, Nurhan/D-5626-2009
dc.authorwosidAkdemir, Fatih/AAG-8010-2019
dc.authorwosidYilmaz, Ismet/H-4144-2019
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.authorwosidGENCOGLU, HASAN/Q-2668-2015
dc.contributor.authorSahin, Kazim
dc.contributor.authorOrhan, Cemal
dc.contributor.authorAkdemir, Fatih
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorGencoglu, Hasan
dc.contributor.authorSahin, Nurhan
dc.contributor.authorTurk, Gaffari
dc.date.accessioned2024-08-04T20:42:36Z
dc.date.available2024-08-04T20:42:36Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Mucuna pruriens, Tribulus terrestris and Ashwagandha (Withania somnifera) are widely known as antioxidant effective herbals and have been reported to possess aphrodisiac activities in traditional usages. In this study, we determined the effects of these herbals on sexual functions, serum biochemical parameters, oxidative stress and levels of NF-kappa B, Nrf2, and HO-1 in reproductive tissues. Methods: Thirty-five male rats were divided into five groups: the control group, sildenafil-treated group (5 mg/kg/d), Mucuna, Tribulus and Ashwagandha groups. The extract groups were treated orally either with Mucuna, Tribulus or Ashwagandha (300 mg/kg b.w.) for 8 weeks. Results: All of the extracts were found to be significantly effective in sexual functioning and antioxidant capacity and Tribulus showed the highest effectiveness. Serum testosterone levels significantly increased in Tribulus and Ashwagandha groups in comparison to control group. Tribulus was able to reduce the levels of NF-kappa B and increase the levels of Nrf2 and HO-1 to a much greater extent than Mucuna and Ashwagandha. Conclusions: These results demonstrate for the first time that Mucuna, Tribulus and Ashwagandha supplementation improves sexual function in male rats via activating Nrf(2)/HO-1 pathway while inhibiting the NF-kappa B levels. Moreover, Tribulus terrestris extract was found to be more bioavailable from Ashwagandha extract followed by Mucuna extract.en_US
dc.description.sponsorshipOmniactive Health Technologies (NJ, USA); Turkish Academy of Sciences (Ankara, Turkey)en_US
dc.description.sponsorshipThe study was financially supported by the Omniactive Health Technologies (NJ, USA) and Turkish Academy of Sciences (Ankara, Turkey).en_US
dc.identifier.doi10.1186/s12906-016-1303-x
dc.identifier.issn1472-6882
dc.identifier.pmid27561457en_US
dc.identifier.scopus2-s2.0-84983380022en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1186/s12906-016-1303-x
dc.identifier.urihttps://hdl.handle.net/11616/97480
dc.identifier.volume16en_US
dc.identifier.wosWOS:000382207500005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Complementary and Alternative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMucuna pruriensen_US
dc.subjectTribulus terrestrisen_US
dc.subjectWithania somniferaen_US
dc.subjectSexual enhanceren_US
dc.subjectFertilityen_US
dc.subjectReproductive organsen_US
dc.titleComparative evaluation of the sexual functions and NF-?B and Nrf2 pathways of some aphrodisiac herbal extracts in male ratsen_US
dc.typeArticleen_US

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