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    In situ palladium/N-heterocyclic carbene complex catalyzed carbonylative cross-coupling reactions of arylboronic acids with 2-bromopyridine under CO pressure: efficient synthesis of unsymmetrical arylpyridine ketones and their antimicrobial activities
    (Springer, 2019) Boubakri, L.; Al-Ayed, Abdullah S.; Mansour, L.; Harrath, A. A.; Al-Tamimi, J.; Ozdemir, I.; Yasar, S.
    The carbonylative Suzuki cross-coupling of 2-bromopyridine with various boronic acids to prepare unsymmetrical arylpyridine ketones has been carried out using palladium/N-heterocyclic carbene complexes as catalysts prepared in situ. The selectivity and the rate of these reactions are highly dependent on the conditions, i.e., nature of the palladium catalyst precursor, solvent, temperature and CO pressure. The main side-products arise from direct, non-carbonylative cross-coupling. Under the optimum conditions, arylpyridine ketones are recovered in high yields (60-88%). The antibacterial activities of the corresponding benzimidazole salts 2 were tested against Gram positive and negative bacteria using the agar dilution procedure, and their IC50 values have been determined.
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    Synthesis, spectroscopic properties and biological activity of new Cu(I) N-Heterocyclic carbene complexes
    (Elsevier, 2019) Touj, N.; Chakchouk-Mtibaa, A.; Mansour, L.; Harrath, A. H.; Al-Tamimi, J.; Mellouli, L.; Ozdemir, I
    New benzimidazolium salts (2) and their copper N-heterocyclic carbene complexes (3 4) were designed, synthesized and structurally characterized by NMR (H-1 and C-13), IR, HRMS and elemental analysis. All obtained complexes especially compounds 3d and 3e, presented significant inhibitory activity against the tested food-borne pathogens and clinical microorganisms. The compound 3b presents against S. aureus a MIC value of 0.0195 mg/ml quite similar to that of ampicillin (0.0195 mg/ml) used as standard. Compounds 3a and 3b, from a concentration of 0.5 mg/ml, present an identical scavenging activity to that of the two used controls butylated hydroxytoluene (BHT) and gallic acid (GA). Concerning acetylcholinesterase inhibition activity (AChEI), compound 3e presents an interesting AChEI activity with 32.80% of inhibition. (C) 2018 Published by Elsevier B.V.