In situ palladium/N-heterocyclic carbene complex catalyzed carbonylative cross-coupling reactions of arylboronic acids with 2-bromopyridine under CO pressure: efficient synthesis of unsymmetrical arylpyridine ketones and their antimicrobial activities
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The carbonylative Suzuki cross-coupling of 2-bromopyridine with various boronic acids to prepare unsymmetrical arylpyridine ketones has been carried out using palladium/N-heterocyclic carbene complexes as catalysts prepared in situ. The selectivity and the rate of these reactions are highly dependent on the conditions, i.e., nature of the palladium catalyst precursor, solvent, temperature and CO pressure. The main side-products arise from direct, non-carbonylative cross-coupling. Under the optimum conditions, arylpyridine ketones are recovered in high yields (60-88%). The antibacterial activities of the corresponding benzimidazole salts 2 were tested against Gram positive and negative bacteria using the agar dilution procedure, and their IC50 values have been determined.
Açıklama
Anahtar Kelimeler
Suzuki-Miyaura Reaction, Nitrogen Double-Bonds, Oxidative Addition, Aryl Chlorides, (Nhc)Pd(Allyl)Cl Nhc, Heteroaryl Halides, Convenient Access, Pyridine Halides, Pd(Ii) Complexes, Boronic Acids
Kaynak
Transition Metal Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
44
Sayı
4
