In situ palladium/N-heterocyclic carbene complex catalyzed carbonylative cross-coupling reactions of arylboronic acids with 2-bromopyridine under CO pressure: efficient synthesis of unsymmetrical arylpyridine ketones and their antimicrobial activities

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dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authoridHarrath, Abdel Halim/0000-0002-2170-1303
dc.authorwosidAl-Tamimi, Jameel H/F-2374-2019
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.authorwosidMANSOUR, Lamjed/AAO-6201-2020
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidHarrath, Abdel Halim/K-2166-2014
dc.contributor.authorBoubakri, L.
dc.contributor.authorAl-Ayed, Abdullah S.
dc.contributor.authorMansour, L.
dc.contributor.authorHarrath, A. A.
dc.contributor.authorAl-Tamimi, J.
dc.contributor.authorOzdemir, I.
dc.contributor.authorYasar, S.
dc.date.accessioned2024-08-04T20:45:36Z
dc.date.available2024-08-04T20:45:36Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe carbonylative Suzuki cross-coupling of 2-bromopyridine with various boronic acids to prepare unsymmetrical arylpyridine ketones has been carried out using palladium/N-heterocyclic carbene complexes as catalysts prepared in situ. The selectivity and the rate of these reactions are highly dependent on the conditions, i.e., nature of the palladium catalyst precursor, solvent, temperature and CO pressure. The main side-products arise from direct, non-carbonylative cross-coupling. Under the optimum conditions, arylpyridine ketones are recovered in high yields (60-88%). The antibacterial activities of the corresponding benzimidazole salts 2 were tested against Gram positive and negative bacteria using the agar dilution procedure, and their IC50 values have been determined.en_US
dc.description.sponsorshipDeanship of Scientific Research at King Saud University [RG-1435-023]en_US
dc.description.sponsorshipThe authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for funding this research group No (RG-1435-023).en_US
dc.identifier.doi10.1007/s11243-018-00298-9
dc.identifier.endpage328en_US
dc.identifier.issn0340-4285
dc.identifier.issn1572-901X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85058962185en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://doi.org/10.1007/s11243-018-00298-9
dc.identifier.urihttps://hdl.handle.net/11616/98585
dc.identifier.volume44en_US
dc.identifier.wosWOS:000468624800003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofTransition Metal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSuzuki-Miyaura Reactionen_US
dc.subjectNitrogen Double-Bondsen_US
dc.subjectOxidative Additionen_US
dc.subjectAryl Chloridesen_US
dc.subject(Nhc)Pd(Allyl)Cl Nhcen_US
dc.subjectHeteroaryl Halidesen_US
dc.subjectConvenient Accessen_US
dc.subjectPyridine Halidesen_US
dc.subjectPd(Ii) Complexesen_US
dc.subjectBoronic Acidsen_US
dc.titleIn situ palladium/N-heterocyclic carbene complex catalyzed carbonylative cross-coupling reactions of arylboronic acids with 2-bromopyridine under CO pressure: efficient synthesis of unsymmetrical arylpyridine ketones and their antimicrobial activitiesen_US
dc.typeArticleen_US

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