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Öğe Acquired IgE-mediated food allergy after liver transplantation in children(Elsevier Espana Slu, 2015) Catal, F.; Topal, E.; Selimoglu, M. A.; Karabiber, H.; Baskiran, A.; Senbaba, E.; Varol, I.Background: In recent years, the number of studies regarding newly-diagnosed food allergies after liver transplantation has been increasing. In this study, we aimed to investigate the frequency, transplantation in children. Methods: Paediatric patients who underwent liver transplantation at Inonu University Faculty of Medicine, Organ Transplantation Institute were included in the study. Results: Forty-nine paediatric patients were enrolled in the study; 26 (53.1%) were female, the median age at transplantation was five years, and median follow-up time after transplantation was 16 months. Six patients (12.2%) developed IgE-mediated food allergies after transplantation; four had urticaria and/or angio-oedema and two developed anaphylaxis after food intake. Patients with and without IgE-mediated disease, immunosuppressant therapy with tacrolimus, and blood tacrolirnus level (p > 0.05 for each). Serum total IgE levels >= 100 IU/mL (p = 0.02) and peripheral eosinophilia (p = 0.026) were more common in the patients who developed IgE-mediated food allergies. In five of the six patients who developed IgE-mediated food allergies, reaction occurred within the first year after transplantation; the risk of developing a reaction was 2.7 times higher within the first year after transplantation than in subsequent years (95% CI, 1.546-4.914; p=0.026). No Epstein-Barr virus or cytomegalovirus infections were detected in any of the patients who developed IgE-mediated food allergies after liver transplantation. Conclusion: The risk of developing IgE-mediated food allergies is approximately three times higher within the first year after transplantation than in subsequent years. (C) 2014 SEICAP Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Association of oxidative stress and dynamic thiol-disulphide homeostasis with atopic dermatitis severity and chronicity in children: a prospective study(Wiley, 2018) Uysal, P.; Avcil, S.; Neselioglu, S.; Bicer, C.; Catal, F.BackgroundOxidative stress (OS) has an important effect on the pathogenesis of atopic dermatitis (AD). Thiols are antioxidants that regulate intracellular redox metabolism and protect keratinocytes against OS damage in the stratum corneum. AimTo investigate dynamic thiol-disulphide homeostasis (dTDH) as a novel OS parameter in children with AD, and its relationship with disease severity and chronicity. MethodsSeverity of AD was determined by using the instruments SCORing Atopic Dermatitis (SCORAD) and Eczema Area And Severity Index (EASI) upon enrolment in the study (SCORAD(1) and EASI(1)) and after 1year (SCORAD(2) and EASI(2)). Native thiol, total thiol and disulphide levels were measured as novel OS parameters, and the ratios of disulphide/native thiol, disulphide/total thiol and native/total thiol were calculated as dTDH. ResultsIn the AD group, the serum disulphide level and the ratios of disulphide/native thiol and disulphide/total thiol were significantly lower than in healthy controls (P=0.01, P<0.01 and P<0.01, respectively). There was no significant association between OS parameters and disease severity (P>0.05). SCORAD(2) and EASI(2) were positively correlated with disulphide/native thiol ratio (r=0.29, P<0.03 and r=0.35, P<0.01, respectively), whereas they were negatively correlated with the native/total thiol ratio (r=-0.30, P=0.02 for both). ConclusionsBoth OS and impaired dTDH were found to be related to childhood AD. None of the OS parameters was associated with AD severity. dTDH is a possible diagnostic tool to predict AD chronicity.Öğe Does atopy affect the course of viral pneumonia?(Elsevier Espana Slu, 2018) Erdem, S. B.; Can, D.; Girit, S.; Catal, F.; Sen, V.; Pekcan, S.; Yuksel, H.Background: The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia. Methods: Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Patients were classified into two groups as mild-moderate and severe according to the course of pneumonia. Presence of atopy was evaluated with skin prick tests. Groups were compared to evaluate the risk factors associated with severe viral pneumonia. Results: A total of 280 patients from nine centres were included in the study. Of these patients, 163 (58.2%) were male. Respiratory syncytial virus (29.7%), Influenza A (20.5%), rhinovirus (18.9%), adenovirus (10%), human metapneumovirus (8%), parainfluenza (5.2%), coronavirus (6%), and bocavirus (1.6%) were isolated from respiratory samples. Eighty-five (30.4%) children had severe pneumonia. Atopic sensitisation was found in 21.4% of the patients. Ever wheezing (RR: 1.6, 95% CI: 1.1-2.4), parental asthma (RR: 1.5, 95% CI: 1.1-2.2), other allergic diseases in the family (RR: 1.8, 95% CI: 1.2-2.9) and environmental tobacco smoke (RR: 1.6, 95% CI: 1.1-3.5) were more common in the severe pneumonia group. Conclusions: When patients with mild-moderate pneumonia were compared to patients with severe pneumonia, frequency of atopy was not different between the two groups. However, parental asthma, ever wheezing and environmental tobacco smoke exposure are risk factors for severe viral pneumonia in children. (C) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Elevated level of serum osteopontin in school-age children with asthma(Elsevier Doyma Sl, 2014) Akelma, A. Z.; Cizmeci, M. N.; Kanburoglu, M. K.; Bozkaya, D.; Catal, F.; Mete, E.; Kutukoglu, I.Background: The role of osteopontin (OPN) has not been elucidated in childhood asthma. Objective: Our purpose was to investigate whether OPN levels change due to allergic inflammation in pre-school and school-age children. Methods: In this prospective, cross-sectional study, 42 healthy children and a total of 51 children with asthma were recruited. OPN levels and its association with clinical and laboratory parameters were investigated in the study population. The asthma group were divided into two groups with respect to age, <= 5-years (n=23) and >5-years (n=28), and labelled Asthma Group 1 and Asthma Group 2, respectively. OPN levels were compared between subgroups. Results: Serum OPN levels were significantly higher in the asthma group when compared to the control group (p=0.004). OPN levels were similar in Asthma Group 1 and control groups, whereas it was found to be higher in Asthma Group 2 (p>0.025, p=0.001, respectively). In the >5-years age asthmatic group, OPN levels of the patients with allergic rhinitis (n=15) were higher than those of the patients (n=13) without allergic rhinitis (p=0.021). Conclusion: The study underscores the relationship between childhood asthma and OPN as the first study in the literature. In this study we found that OPN, which plays a role in Th2 mediated inflammation, may also play a role in childhood asthma. The fact that OPN levels do not increase in preschool-age children with asthma might be due to the transient wheezing in this group. (C) 2012 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.Öğe Level of serum neutrophil gelatinase-associated lipocalin in childhood asthma(Elsevier Doyma Sl, 2015) Akelma, A. Z.; Kanburoglu, M. K.; Cizmeci, M. N.; Mete, E.; Catal, F.; Tufan, N.Background: The role of neutrophil gelatinase-associated lipocalin (NGAL) in childhood asthma remains unknown. This study aimed to measure the serum levels of NGAL in children with asthma and to investigate the correlation between NGAL and transforming growth factor beta 1 (TGF-beta 1), a good indicator of airway remodeling in children with asthma. Methods: This prospective, cross-sectional study was conducted on 75 children. Serum NGAL and TGF-beta 1 concentrations were measured by the ELISA method. Complete blood count, high sensitive C reactive protein (hsCRP), eosinophil cationic protein (ECP), and total serum IgE were investigated in the study population. Atopy in the asthma group was investigated using a skin prick test and specific IgE measurements. Results: Forty-three asthmatic children and 32 healthy children were enrolled in the study. Total eosinophil numbers, white blood cell count, total serum IgE levels and ECP levels were significantly higher in the asthma group than in the control group (p < 0.05). Similarly, serum TGF-beta 1 levels were significantly higher in children with asthma (p = 0.012). The difference in NGAL levels between the groups was insignificant (p = 0.268). NGAL levels did not show a significant correlation with total IgE, ECP, eosinophil numbers and TGF-beta 1 levels (p > 0.05). Conclusion: As a conclusion, while elevated TGF-beta 1 levels in children with asthma might be regarded as an indicator of airway remodeling, we did not find a similar prediction strength for NGAL. Further studies are required to better identify the role of NGAL in childhood asthma and to determine its potential use as a clinical marker. (C) 2013 SEICAR Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Prevalence of allergic rhinoconjunctivitis and risk factors in 6-to 7-year old children in the East of Turkey(Wiley-Blackwell, 2016) Topal, E.; Turker, K.; Catal, F.[Abstract Not Available]Öğe Psychiatric disorders and symptoms severity in pre-school children with cow's milk allergy(Elsevier Doyma Sl, 2016) Topal, E.; Catal, F.; Soylu, N.; Ozcan, O. O.; Celiksoy, M. H.; Babayigit, A.; Erge, D.Background: Psychiatric disorders are seen frequently in atopic diseases. The present study aims to evaluate the frequency of psychiatric disorders and the severity of psychiatric symptoms in pre-school children with cow's milk allergy. Methods: The parents of the pre-school children with cow's milk allergy were interviewed in person and asked to fill out the Early Childhood Inventory-4 form. Results: The cow's milk allergy group included 40 children (27 male, 13 female) with mean age, 44.5 +/- 14.7 months, and the control group included 41 children (25 male, 16 female) with mean age, 47.6 +/- 15.2 months. It was established that 65% of the group with cow's milk allergy received at least one psychiatric diagnosis, while 36.6% of the control group received at least one psychiatric diagnosis, with a statistically significant difference (p = 0.02). Within the psychiatric disorders, attention deficit hyperactivity disorders (odds ratio: 4.9, 95% CI: 1.472-16.856, p = 0.006), oppositional defiant disorder (odds ratio: 5.6, 95% CI: 1.139-28.128, p = 0.026), and attachment disorder (odds ratio: 4.8, 95% CI: 1.747-13.506, p = 0.004) were found significantly higher compared with the healthy control group. When the groups were compared in terms of psychiatric symptom severity scores, calculated by using the Early Childhood Inventory-4 form, attention deficit hyperactivity disorders severity (p= 0.006) and oppositional defiant disorder severity (p = 0.037) were found to be higher in the cow's milk allergy group. Conclusion: Psychiatric disorders are frequent and severe in pre-school children with cow's milk allergy. (C) 2016 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Psychiatric disorders and symptoms severity in preschool children with atopic eczema(Elsevier Espana Slu, 2016) Catal, F.; Topal, E.; Soylu, N.; Ozcan, O. Ozel; Celiksoy, M. H.; Babayigit, A.; Karakoc, H. T. E.Background: To compare with a control group the frequency of psychiatric disorders and severity of psychiatric symptoms in preschool children with atopic eczema. Methods: The study included children between the ages of 3-5 who were diagnosed to have atopic eczema. The parents of the children with atopic eczema were interviewed in person and were asked to fill in The Early Childhood Inventory-4 form. This form assesses the psychiatric disorders and symptoms severity in children between the ages of 3-5. Results: The atopic eczema group included 80 patients (38 male, 42 female) with a mean age of 48.4 +/- 15.7 months and the control group included 74 patients (41 male, 33 female) with a mean age of 49.9 +/- 15.19 months. It was established that 68.8% of the group with atopic eczema received at least one psychiatric diagnosis. Between the psychiatric disorders, ADHD (Odds ratio: 2.57, 95% CI: 1.049-6.298, p=0.035), enuresis and encopresis (Odds ratio: 2.39, 95% CI: 1.121-5.097, p=0.022) and attachment disorder (Odds ratio: 2.03, 95% CI: 1.046-3.953, p=0.035) were found to be significantly higher when compared with the healthy control group. When the groups were compared in terms of psychiatric symptom severity scores calculated by using ECI-4, ADHD severity (p=0.043), conduct disorder severity (p=0.001), anxiety disorders severity (p < 0.001), eating disorders severity (p = 0.011) and tic disorder severity (p = 0.01) were found to be higher in the atopic eczema group. Conclusion: Psychiatric illnesses are frequent in preschool children with atopic eczema. (C) 2015 SEICAP. Published by Elsevier Esparta, S.L.U. All rights reserved.Öğe Psychiatric disorders and symptoms severity in preschool children with cow's milk allergy(Wiley-Blackwell, 2016) Topal, E.; Catal, F.; Soylu, N.; Ozcan, O. O.; Celiksoy, M. H.; Babayigit, A.; Erge, D.[Abstract Not Available]Öğe The value of the clinical history for the diagnosis of immediate NSAIDs hypersensitivity and safe alternative drugs in children(Wiley-Blackwell, 2016) Topal, E.; Celiksoy, M. H.; Catal, F.; Sayan, Y. G.; Sancak, R.[Abstract Not Available]
