Elevated level of serum osteopontin in school-age children with asthma
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Doyma Sl
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The role of osteopontin (OPN) has not been elucidated in childhood asthma. Objective: Our purpose was to investigate whether OPN levels change due to allergic inflammation in pre-school and school-age children. Methods: In this prospective, cross-sectional study, 42 healthy children and a total of 51 children with asthma were recruited. OPN levels and its association with clinical and laboratory parameters were investigated in the study population. The asthma group were divided into two groups with respect to age, <= 5-years (n=23) and >5-years (n=28), and labelled Asthma Group 1 and Asthma Group 2, respectively. OPN levels were compared between subgroups. Results: Serum OPN levels were significantly higher in the asthma group when compared to the control group (p=0.004). OPN levels were similar in Asthma Group 1 and control groups, whereas it was found to be higher in Asthma Group 2 (p>0.025, p=0.001, respectively). In the >5-years age asthmatic group, OPN levels of the patients with allergic rhinitis (n=15) were higher than those of the patients (n=13) without allergic rhinitis (p=0.021). Conclusion: The study underscores the relationship between childhood asthma and OPN as the first study in the literature. In this study we found that OPN, which plays a role in Th2 mediated inflammation, may also play a role in childhood asthma. The fact that OPN levels do not increase in preschool-age children with asthma might be due to the transient wheezing in this group. (C) 2012 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.
Açıklama
Anahtar Kelimeler
Osteopontin, Childhood asthma, Preschool children, Persistent wheezing
Kaynak
Allergologia Et Immunopathologia
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
42
Sayı
4
