Elevated level of serum osteopontin in school-age children with asthma

Basit Öğe Kaydı
dc.authoridAkelma, Zülfikar/0000-0003-0140-5053
dc.authoridKanburoglu, Mehmet Kenan/0000-0001-6859-6689
dc.authoridbozkaya, davut/0000-0001-5548-7387
dc.authorwosidAkelma, Zülfikar/GPT-0838-2022
dc.authorwosidKanburoglu, Mehmet Kenan/B-9255-2018
dc.authorwosidbozkaya, davut/D-7483-2019
dc.contributor.authorAkelma, A. Z.
dc.contributor.authorCizmeci, M. N.
dc.contributor.authorKanburoglu, M. K.
dc.contributor.authorBozkaya, D.
dc.contributor.authorCatal, F.
dc.contributor.authorMete, E.
dc.contributor.authorKutukoglu, I.
dc.date.accessioned2024-08-04T20:39:48Z
dc.date.available2024-08-04T20:39:48Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The role of osteopontin (OPN) has not been elucidated in childhood asthma. Objective: Our purpose was to investigate whether OPN levels change due to allergic inflammation in pre-school and school-age children. Methods: In this prospective, cross-sectional study, 42 healthy children and a total of 51 children with asthma were recruited. OPN levels and its association with clinical and laboratory parameters were investigated in the study population. The asthma group were divided into two groups with respect to age, <= 5-years (n=23) and >5-years (n=28), and labelled Asthma Group 1 and Asthma Group 2, respectively. OPN levels were compared between subgroups. Results: Serum OPN levels were significantly higher in the asthma group when compared to the control group (p=0.004). OPN levels were similar in Asthma Group 1 and control groups, whereas it was found to be higher in Asthma Group 2 (p>0.025, p=0.001, respectively). In the >5-years age asthmatic group, OPN levels of the patients with allergic rhinitis (n=15) were higher than those of the patients (n=13) without allergic rhinitis (p=0.021). Conclusion: The study underscores the relationship between childhood asthma and OPN as the first study in the literature. In this study we found that OPN, which plays a role in Th2 mediated inflammation, may also play a role in childhood asthma. The fact that OPN levels do not increase in preschool-age children with asthma might be due to the transient wheezing in this group. (C) 2012 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.en_US
dc.identifier.doi10.1016/j.aller.2013.01.009
dc.identifier.endpage281en_US
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue4en_US
dc.identifier.pmid23578778en_US
dc.identifier.scopus2-s2.0-84903816141en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://doi.org/10.1016/j.aller.2013.01.009
dc.identifier.urihttps://hdl.handle.net/11616/96497
dc.identifier.volume42en_US
dc.identifier.wosWOS:000339227000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Doyma Slen_US
dc.relation.ispartofAllergologia Et Immunopathologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOsteopontinen_US
dc.subjectChildhood asthmaen_US
dc.subjectPreschool childrenen_US
dc.subjectPersistent wheezingen_US
dc.titleElevated level of serum osteopontin in school-age children with asthmaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu