Acquired IgE-mediated food allergy after liver transplantation in children
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Espana Slu
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: In recent years, the number of studies regarding newly-diagnosed food allergies after liver transplantation has been increasing. In this study, we aimed to investigate the frequency, transplantation in children. Methods: Paediatric patients who underwent liver transplantation at Inonu University Faculty of Medicine, Organ Transplantation Institute were included in the study. Results: Forty-nine paediatric patients were enrolled in the study; 26 (53.1%) were female, the median age at transplantation was five years, and median follow-up time after transplantation was 16 months. Six patients (12.2%) developed IgE-mediated food allergies after transplantation; four had urticaria and/or angio-oedema and two developed anaphylaxis after food intake. Patients with and without IgE-mediated disease, immunosuppressant therapy with tacrolimus, and blood tacrolirnus level (p > 0.05 for each). Serum total IgE levels >= 100 IU/mL (p = 0.02) and peripheral eosinophilia (p = 0.026) were more common in the patients who developed IgE-mediated food allergies. In five of the six patients who developed IgE-mediated food allergies, reaction occurred within the first year after transplantation; the risk of developing a reaction was 2.7 times higher within the first year after transplantation than in subsequent years (95% CI, 1.546-4.914; p=0.026). No Epstein-Barr virus or cytomegalovirus infections were detected in any of the patients who developed IgE-mediated food allergies after liver transplantation. Conclusion: The risk of developing IgE-mediated food allergies is approximately three times higher within the first year after transplantation than in subsequent years. (C) 2014 SEICAP Published by Elsevier Espana, S.L.U. All rights reserved.
Açıklama
Anahtar Kelimeler
Children, Food, Allergy, Liver, Transplantation, IgE-mediated, Tacrolimus
Kaynak
Allergologia Et Immunopathologia
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
43
Sayı
4
