Acquired IgE-mediated food allergy after liver transplantation in children

dc.authoridtopal, erdem/0000-0002-4439-2689
dc.authoridBASKIRAN, ADIL/0000-0002-7536-1631
dc.authoridVarol, İlknur fatma/0000-0001-5212-218X
dc.authorwosidtopal, erdem/ABI-7545-2020
dc.authorwosidBASKIRAN, ADIL/ABI-2356-2020
dc.authorwosidVarol, İlknur fatma/ABH-6387-2020
dc.contributor.authorCatal, F.
dc.contributor.authorTopal, E.
dc.contributor.authorSelimoglu, M. A.
dc.contributor.authorKarabiber, H.
dc.contributor.authorBaskiran, A.
dc.contributor.authorSenbaba, E.
dc.contributor.authorVarol, I.
dc.date.accessioned2024-08-04T20:40:21Z
dc.date.available2024-08-04T20:40:21Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: In recent years, the number of studies regarding newly-diagnosed food allergies after liver transplantation has been increasing. In this study, we aimed to investigate the frequency, transplantation in children. Methods: Paediatric patients who underwent liver transplantation at Inonu University Faculty of Medicine, Organ Transplantation Institute were included in the study. Results: Forty-nine paediatric patients were enrolled in the study; 26 (53.1%) were female, the median age at transplantation was five years, and median follow-up time after transplantation was 16 months. Six patients (12.2%) developed IgE-mediated food allergies after transplantation; four had urticaria and/or angio-oedema and two developed anaphylaxis after food intake. Patients with and without IgE-mediated disease, immunosuppressant therapy with tacrolimus, and blood tacrolirnus level (p > 0.05 for each). Serum total IgE levels >= 100 IU/mL (p = 0.02) and peripheral eosinophilia (p = 0.026) were more common in the patients who developed IgE-mediated food allergies. In five of the six patients who developed IgE-mediated food allergies, reaction occurred within the first year after transplantation; the risk of developing a reaction was 2.7 times higher within the first year after transplantation than in subsequent years (95% CI, 1.546-4.914; p=0.026). No Epstein-Barr virus or cytomegalovirus infections were detected in any of the patients who developed IgE-mediated food allergies after liver transplantation. Conclusion: The risk of developing IgE-mediated food allergies is approximately three times higher within the first year after transplantation than in subsequent years. (C) 2014 SEICAP Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.identifier.doi10.1016/j.aller.2014.05.003
dc.identifier.endpage397en_US
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue4en_US
dc.identifier.pmid25201761en_US
dc.identifier.scopus2-s2.0-84937633438en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage392en_US
dc.identifier.urihttps://doi.org/10.1016/j.aller.2014.05.003
dc.identifier.urihttps://hdl.handle.net/11616/96876
dc.identifier.volume43en_US
dc.identifier.wosWOS:000357842600009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofAllergologia Et Immunopathologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectFooden_US
dc.subjectAllergyen_US
dc.subjectLiveren_US
dc.subjectTransplantationen_US
dc.subjectIgE-mediateden_US
dc.subjectTacrolimusen_US
dc.titleAcquired IgE-mediated food allergy after liver transplantation in childrenen_US
dc.typeArticleen_US

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