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Öğe An antibody of TNF alpha did not prevent thioacetamide induced hepatotoxicity in rats(Human&experimental toxicology, 2011) Demirel, Ulvi; Harputoğlu, Muhsin Murat Muhip; Seçkin, Yüksel; Çıralık, Harun; Temel, İsmail; Özyalın, Fatma; Otlu, Barış; Yılmaz, Bilgiç; Dinçtürk, Mehmet Sarp; Aladağ, HülyaTumor necrosis factor (TNF)-a antibodies have been shown to reduce liver damage in different models. We investigated the effects of infliximab (a TNF-a antibody) on liver damage in thioacetamide (TAA)-induced hepatotoxicity in rats. Group 1 (n ¼ 8) was the control group. In group 2 (n ¼ 8), the TAA group, the rats received 300 mg/kg intraperitoneal (ip) TAA daily for 2 days. In group 3 (n ¼ 8), the TAA þ Infliximab (INF) group, infliximab (5 mg/kg ip daily) was administered 48 hours before the first dose of TAA daily for 2 days and was maintained for 4 consecutive days. In group 4 (n ¼ 8), the INF group, the rats received only ip infliximab (5 mg/kg) daily. Livers were excised for histopathological and biochemical tests (thiobarbituric-acid-reactive substances [TBARS], and myeloperoxidase [MPO]). Serum ammonia, aspartate transaminase (AST), alanine transaminase (ALT), TNF-a, liver TBARS and MPO levels, and liver necrosis and inflammation scores in the TAA group were significantly higher than in the control and INF groups (all p < 0.01). All parameters except AST were not significantly different between TAA and TAA þ INF. In conclusion, our results suggest that oxidative stress plays an important role in TAA-induced hepatotoxicity, and infliximab does not improve oxidative liver damage.Öğe An antibody of TNF-alpha did not prevent thioacetamide-induced hepatotoxicity in rats(Sage Publications Ltd, 2011) Demirel, Ulvi; Harputluoglu, Murat M. M.; Seckin, Yuksel; Ciralik, Harun; Temel, Ismail; Ozyalin, Fatma; Otlu, BarisTumor necrosis factor (TNF)-alpha antibodies have been shown to reduce liver damage in different models. We investigated the effects of infliximab (a TNF-alpha antibody) on liver damage in thioacetamide (TAA)-induced hepatotoxicity in rats. Group 1 (n = 8) was the control group. In group 2 (n = 8), the TAA group, the rats received 300 mg/kg intraperitoneal (ip) TAA daily for 2 days. In group 3 (n = 8), the TAA + Infliximab (INF) group, infliximab (5 mg/kg ip daily) was administered 48 hours before the first dose of TAA daily for 2 days and was maintained for 4 consecutive days. In group 4 (n = 8), the INF group, the rats received only ip infliximab (5 mg/kg) daily. Livers were excised for histopathological and biochemical tests (thiobarbituric-acid-reactive substances [TBARS], and myeloperoxidase [MPO]). Serum ammonia, aspartate transaminase (AST), alanine transaminase (ALT), TNF-alpha, liver TBARS and MPO levels, and liver necrosis and inflammation scores in the TAA group were significantly higher than in the control and INF groups (all p < 0.01). All parameters except AST were not significantly different between TAA and TAA + INF. In conclusion, our results suggest that oxidative stress plays an important role in TAA-induced hepatotoxicity, and infliximab does not improve oxidative liver damage.Öğe Comparison of pantoprazole- vs. omeprazole- based triple therapy regimens in the treatment of Helicobacter pylori infection and duodenal ulcer healing in a Turkish population(2005) Aladağ, Murat; Kantarçeken, Bülent; Karıncaoğlu, Melih; Sertkaya, Ayşe; Çıkım, Kerim; Harputluoğlu, M. M. Murat; Demirel, Ulvi[Abstract Not Available]Öğe The effects of Gingko biloba extract on acetic acid induced colitis in rats(Turk J Gastroenterol, 2006) Harputluoğlu, Muhsin Murat Muhip; Demirel, Ulvi; Yücel, Neslihan; Karadağ, Neşe; Temel, İsmail; Fırat, Serpil; Ara, Cengiz; Aladağ, MuratBackground/aims: Gingko biloba is an antioxidant substance which has antagonistic activity on platelet-activating factor. We aimed to investigate the antioxidant effect and the histopathologic changes caused by Gingko biloba on acetic acid-induced colitis. Methods: Totally 22 rats were divided into three groups. Group 1 (n=7) served as the control group. Group 2 (n=7) and Group 3 (n=8) were given 2 ml/day of 4% acetic acid by intracolonic instillation for three days. Gingko biloba (100 mg/kg) was then given only to Group 3 intraperitoneally for three days. Oxidative stress was assessed by determinate tissue and serum malondialdehyde (MDA) levels, and colonic damage was assessed by histologic examination. Results: Depth of necrosis, extent of necrosis, degree of inflammation, extent of inflammation, fibrosis and total histologic scores in Group 2 were significantly higher than in the control group (p<0.05). The same parameters were lower in Group 3 versus Group 2, but the difference was not significant. Tissue and serum MDA levels in Group 2 were significantly higher than Group 1 (p<0.01 and 0.05, respectively). Again, the same parameters in Group 3 were lower than in Group 2, but the difference was not significant statistically. Conclusions: Gingko biloba did not significantly affect histopathological and oxidative stress parameters in experimental colitis.Öğe The effects of Gingko biloba extract on acetic acidinduced colitis in rats(Turkish Journal of Gastroenterology, 2006) Harputluoglu, Murat M.; Demirel, Ulvi; Yücel, Neslihan; Karadağ, Neşe; Temel, İsmail; Fırat, Serpil; Aladağ, Murat; Karıncaoğlu, Melih; Hilmoğlu, FatihÖz: Amaç: Gingko biloba platelet aktivatör faktör antagonistik etkiye sahip antioksidan bir maddedir. Biz ratlarda asetik asit ile oluşturulmuş kolitte Gingko biloba'nın antioksidan ve histo-patolojik etkilerini araştırmayı amaçladık. Yöntem: Toplam 22 rat üç gruba ayrıldı. Grup 1 (n-7) kontrol grubuydu. Grup 2 (n=7) ve grup 3 (n=8)'e 3 gün kolon içerisine rektal yoldan 2 mi I gün %4 asetik asit verildi. Grup 3'e eş zamalı 3 gün 100 mglkg intraperitoneal şekilde Gingko biloba verildi. Oksidatif stres doku ve serumda malondialdehit düzeylerinin ölçülmesiyle, kolon hasarı ise histopatolojik incelemeyle değerlendirildi. Bulgular: Grup 2'de nekroz derinliği, nekroz yaygınlığı, infla-masyon derecesi, infalamsyon yaygınlığı, fibrozis ve total histolojik skorlar kontrol grubundan anlamlı yüksekti (p<0.05). Aynı parametreler grup 3'de grup 2'den daha düşüktü ancak fark anlamlı değildi. Grup 2'de doku ve serum malondialdehit düzeyleri grup l'den anlamlı yüksekti (p<0.05). Aynı parametreler grup 3 de grup 2'den daha düşüktü ancak fark istatistiksel olarak anlamsızdı. Sonuç: Gingko biloba deneysel kolitte histopatolojik ve oksidatif stres parametrelerini anlamlı etkilemedi.Öğe Effects of Lycium barbarum on bacterial translocation in thioacetamide induced liver injury in rats(European Journal of Inflammation, 2015) Bilgiç, Yılmaz; Harputluoğlu, Murat; Kutlu, O; Demirel, Ulvi; Gül, Mehmet; Otlu, Barış; Temel, İsmail; Gürsoy, S.; Dertli, Ramazan; Selçuk, Engin Burak; Yılmaz, İsmet; Kilis, TubaBackground and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum. Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency. Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model.Öğe Effects of Rifaximin on Bacterial Translocation in Thioacetamide-Induced Liver Injury in Rats(Springer/Plenum Publishers, 2012) Harputluoglu, Murat M. M.; Demirel, Ulvi; Gul, Mehmet; Temel, Ismail; Gursoy, Sule; Selcuk, Engin Burak; Aladag, MuratIntestinal bacterial overgrowth (IBO) and increased mucosal permeability are suggested to increase bacterial translocation (BT) in liver injury. Rifaximin (RIF) is a minimally absorbed oral antimicrobial agent that restores gut microflora imbalance. The aim of the present study was to investigate the effects of RIF on BT frequency in thioacetamide (TAA)-induced liver injury. Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA + RIF), RIF was commenced on the same day as the first dose of TAA. In group 4 (RIF), rats received only RIF. Ileal aspirate Escherichia coli counts were significantly lower in the TAA + RIF group than in TAA group. There was no difference in BT frequency between the TAA and TAA + RIF groups. Our results suggest that factors such as intestinal barrier dysfunction and impaired host immune shield, apart from IBO, play an important role in BT in this model.Öğe Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats(Aves, 2017) Harputluoglu, Murat Muhsin Muhip; Temel, Ismail; Demirel, Ulvi; Seckin, Yuksel; Aladag, Murat; Otlu, Baris; Karadag, NeseBackground/Aims: Steroids have been shown to prevent intestinal oxidative stress. We investigated the effects of methylprednisolone on intestinal oxidative damage and bacterial translocation in thioacetamide-induced liver failure in rats. Materials and Methods: Group 1 (n=8) was the control group. In group 2 (n=8), the thioacetamide group, rats received 300 mg/kg intraperitoneal thioacetamide daily for 2 days. In group 3 (n=8), the thioacetami de+methylprednisolone group, treatment with methylprednisolone (30 mg/kg intraperitoneal) was commenced 48 h before the first dose of thioacetamide. In group 4 (n=8), the methylprednisolone group, the rats received only methylprednisolone (30 mg/kg intraperitoneal). Results: Serious hepatic and intestinal oxidative damage and high bacterial translocation frequencies were observed in the thioacetamide group compared with those of the controls. Bacterial translocation frequency in the thioacetamide+methylprednisolone group was significantly lower than that in the thioacetamide group (p<0.05). Intestinal thiobarbituric acid-reactive substances and myeloperoxidase levels and tissue damage scores for the intestines in the thioacetamide+methylprednisolone group were lower than those in the thioacetamide group (p<0.01, p<0.01, and p<0.0001, respectively). Conclusion: Our findings suggest that methylprednisolone reduces bacterial translocation by preventing intestinal oxidative damage in this model of acute liver failure in rats.Öğe Myelodysplastic Syndrome in an Acromegaly Patient: A Case Report(Galenos Yayincilik, 2005) Sari, Ramazan; Demirel, Ulvi; Sahin, Ibrahim; Aydogdu, Ismet; Mizrak, Bulent; Taskapan, HulyaAcromegaly patients have higher incidence of neoplasia than the general population, especially for colonic carcinoma. Recently, various hematological malignancies have been reported in patients with acromegaly. However, myelodysplastic syndrome has not been reported in acromegaly previously. In this paper, we reported a unique patient with acromegaly and concomitant pancytopenia and myelodysplastic syndrome.Öğe Nucleotide-Binding Oligomerization Domain-Containing Protein 2 Variants in Patients with Spontaneous Bacterial Peritonitis(Springer, 2016) Harputluoglu, Murat M. M.; Dertli, Ramazan; Otlu, Baris; Demirel, Ulvi; Yener, Ozkan; Bilgic, Yilmaz; Erdogan, Mehmet AliThe occurrence of spontaneous bacterial peritonitis (SBP) is significantly increased in carriers of nucleotide-binding oligomerization domain-containing protein 2 (NOD2) variants, suggesting that local immune alterations might be implicated in bacterial translocation (BT). We aimed to assess the role of the NOD2 gene in conferring susceptibility to SBP. We also sought to determine whether levels of serum interleukin-6 (IL-6), lipopolysaccharide-binding protein, and soluble TNF-alpha receptor, along with the presence of bacterial DNA (bactDNA) in ascitic fluid, are appropriate markers for BT in patients with liver cirrhosis and SBP. A cohort of 171 patients was divided into two groups: patients with SBP (n = 82) and those without SBP (n = 89). The presence of the most common NOD2 variants (p.R702W, p.G908R, and c.3020insC) was determined in these patients. We detected the p.G908R variant in four patients (4.9 %) of the SBP group. No significant difference was observed between the SBP and non-SBP groups for NOD2 risk variants. The frequency of bactDNA in ascitic fluid was higher for patients with NOD2 variants than for patients without variants (p = 0.021). Serum IL-6 levels in the SBP group were higher than those in the non-SBP group. The frequent detection of bactDNA in ascites of patients with the p.G908R variant suggests there is a strong association between NOD2 risk variants and BT in SBP patients. In addition, increased serum IL-6 levels and bactDNA in ascitic fluid could be considered surrogate markers for BT in patients with cirrhosis.Öğe Pancreatic pseudocyst development due to organophosphate poisoning(Turkish Journal of Gastroenterology, 2007) Harputluoğlu, M. Murat; Demirel, Ulvi; Alan, Hakan; Ateş, Fehmi; Aladağ, Murat; Karıncaoğlu, Melih; Hilmioğlu, FatihÖz: AAmaç: Akut pankreatit, organofosfat zehirlenmesinin ciddi bir komplikasyonudur. Literaturde organofosfat ile oluşan akut pankreatit sonrası pankreatik psodokist gelişimiyle ilgili yayın bulunmamaktadır. Bu nedenle, organofosfat ile oluşan akut pankreatit sonrası pankreatik psodokist gelişen bir vakayı sunuyoruz. Yöntem: Organofosfat insektisit (DDVP EC 550, diklorvos) alım oykusu olan 17 yaşında bir kadın hasta kolinerjik semptomlarla başvurdu. Başvuruda, serum amilaz ve lipaz duzeyleri yuksekti ve abdominal ultrasonografi incelemesinde odematoz pankreas izlendi. Akut pankreatit icin herhangi bir etyolojik faktor yoktu. Bulgular: Organofosfat ile oluşan akut pankreatit teşhis ettik. Dort hafta sonra, abdominal ultrasonografi ve komputerize tomografide 6 cm capında pankreatik psodokist izlendi. Takip sırasında pankreatik psodokist capı 4 cm’ye geriledi. Sonuç: Sonucta organofosfat zehirlenmesi, akut pankreatit ve komplikasyonlarına yol acabilir. Erken teşhis ve uygun tedavi morbidite ve mortaliteyi azaltabilir.Öğe Pancreatic pseudocyst development due to organophosphate poisoning(Turkish Soc Gastroenterology, 2007) Harputluoglu, M. M. Murat; Demirel, Ulvi; Alan, Hakan; Ates, Fehmi; Aladag, Murat; Karincaoglu, Melih; Hilmioglu, FatihBackground/aims: Acute pancreatitis is a serious complication of organophosphate poisoning. There is no report in the literature dealing with the development of a pancreatic pseudocyst after complication of organophosphate-induced acute pancreatitis. Therefore, we present a case who developed pancreatic pseudocyst after complication of organophosphate-induced acute pancreatitis. Methods: A 17-year-old female patient with a history of ingestion of complication of organophosphate insecticide (DDVP EC 550, dichlorvos) was admitted with cholinergic symptoms. On admission, serum. amylase and lipase levels were high and abdominal ultrasonography showed an edematous pancreas. No etiological factor for acute pancreatitis was evident. Results: We diagnosed complication of organophosphate-induced acute pancreatitis. After four weeks, abdominal abdominal ultrasonography and computerized tomography revealed a pancreatic pseudocyst of 6 cm diameter. During follow-up, the pancreatic pseudocyst size regressed to 4 cm. Conclusion: Complication of organophosphate poisoning can cause acute pancreatitis and its complications. Early diagnosis and appropriate treatment may reduce morbidity and mortality.Öğe Portal hipertansiyonun iki bulgusu: serum asit albumin gradienti ve özofagus varislerinin korelasyon değerlendirilmesi(İnönü Üniversitesi, 2002) Demirel, UlviAsit sıvısı etyolojisinin belirlenmesinde total protein düzeyine göre eksuda veya transuda şeklinde yapılan sınıflandırmada tanısal değerinin %55.6’yı geçemeyeceği son yıllarda yapılan birçok çalışmada gösterilmiştir. Bu tip sınıflandırmanın bir diğer klinik dezavantajı ise infeksiyon, diüretik kullanımı ve parasentezden belirgin olarak etkilenmesidir. Geleneksel sınıflandırmanın aksine serum-asit albumin gradiyentine (SAAG) göre asit mayinin portal hipertansiyon ilişkili veya portal hipertansiyon ilişkisiz şeklinde yapılan sınıflandırmanın etyolojik nedeni belirlemede çocuklarda nispeten düşük olsa da erişkinlerde %97’lere varan doğruluk oranı olduğu birçok çalışmada gösterilmiştir. Ayrıca bu şekilde yapılan sınıflandırmanın infeksiyon varlığından, diüretik kullanımından ve parasentezden etkilenmediği de gösterilmiştir.Öğe Ratlarda tiyoaset amit ile oluşturulan fulminan hepatik yetmezlikte gingko biloba, vitamin E ve melatoninin bakteriyel translokasyon üzerine etkileri(İnönü Üniversitesi, 2006) Demirel, UlviBakteriyel translokasyon (BT), fulminan karaciğer yetmezliği (FKY) gibi birçok ciddi klinik durumda infeksiyöz komplikasyonların gelişiminde yerleşmiştir. Biz ratlarda tiyoasetamit (TAA) ile oluşturulan FKY'de Gingko biloba (GB), vitamin E (Vit E) ve melatoninin intestinal oksidatif hasar ve bakteriyel translokasyon üzerine etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Toplam 42 rat 5 gruba ayrıldı. Grup1 (n=8) kontrol grubuydu. Grup 2 (n=10) TAA grubuydu ve bu grupatki ratlar 3 gün boyunca intraperitoneal (ip) olarak 350 mg/k/gün TAA aldı. Grup 3 (n=8)'e oral 100mg/kg/gün GB, grup 4 (n=8)'e oral 200 mg/kg/gün Vit E, grup5 (n=8)'e intraperitoneal 3 mg/kg/gün melatonin tedavisi ilk TAA dozundan 48 saat önce başlandı ve devam eden 5 gün boyunca sürdürüldü. Bulgular: Kontrol grubuyla karşılaştırıldığında TAA grubunda ciddi hepatik ve intestinal oksidatif hasar, ileal aspiratlarda artmış Escherichia coli sayıları ve yüksek BT sıklıkları gözlendi (tüm p değerleri <0.001). Sadece GB tedavisi hepatik oksidatif hasarı azalttı (p<0.001). İntestinal oksidatif hasar, ileal aspiratlardaki E. coli sayıları ve BT sıklıklarında TAA ve diğer antioksidan tedavi grupları arasında fark yoktu (p>0.05). 30 Sonuç: Sonuçlarımız intestinal oksidatif hasarın intestinal mukozanın bariyer fonksiyonunu bozarak BT gelişmesinde önemli rol oynadığını düşündürmektedir.Öğe Two findings of portal hypertension: Evaluation of correlation between serum-ascites albumin gradient and esophageal varices in non-alcoholic cirrhosis(Turkish Journal of Gastroenterology, 2003) Demirel, Ulvi; Karıncaoğlu, Melih; Harputluoğlu, Murat; Ateş, Mehmet; Seçkin, Yüksel; Yıldırım, Bülent; Hilmioğlu, FatihÖz: Amaç: Özofagus varisleri ve serum asit albumin gradiyenti (SAAG) portal hipertansiyonun önemli iki bulgusudur. Son yıllarda alkole bağlı siroz hastalarında bu iki bulgu arasında korelasyon gösterilse de nonalkolik siroz vakalarına ait veri azdır. Yöntem: Ocak 2002-Haziran 2003 tarihleri arasında asit tespit edilen 45 nonalkolik sirozlu hastada serum ve asit albumin ölçümleri yanında özofagus varisleri değerlendirildi. Bulgular: 45 hastadan 32'si erkek, 13'i kadındı. Ortalama yaş 56.3 ±12.5, yaş aralığı 22-85 arasında bulundu. 35 hastada etken hepatitis B, 6 hastada Hepatitis C tespit edilirken 4 hastada etyoloji saptanamadı. Olgularda serum albumin düzeyi 2.53±0.53 gri di, asit albumin düzeyi 0.42±0.31 gri di, SAAG 2.1±0.51 bulundu. Endoskopik özofagus incelemesinde 4 olguda varis görülmezken 15 olguda birinci derece, 18 olguda ikinci derece, 8 olguda üçüncü derece varis görüldü. Özofagus varis derecesi ile serum albumini (p-0.7) ve SAAG (p-0.2) arasında korelasyon yoktu, asit albumini ile çok zayıf da olsa korelasyon bulundu (p=0.03, r=0.30). Ayrıca SAAG değerlerine göre olgular sınıflandırılarak varisleri değerlendirildi. SAAG 1.1-1.49 arasındaki 4 olgunun 2'sinde varis vardı, SAAG 1.5-1.99 arasındaki 15 olgudan 13'inde varis vardı, SAAG 2'nin üzerinde olan olguların ise tümünde varis vardı. Sonuç: Tüm non alkolik siroz olgularımızda literatürü destekler şekilde SAAG 1.1 değerinin üzerindedir. Alkole bağlı siroz hastalarında özofagus varisleri ile arasındaki korelasyon, nonalkolik sirozlu hastalarımızda gösterilememiştir. Asit tespit ettiğimiz 45 nonalkol sirozlu hastanın 4'inde varis olması, SAAG 2.0' nin üzerinde olan tüm olgularda özofagus varislerinin bulunması da dikkat çekicidir.Öğe An uncommon presentation in behçet s disease recovered descending colon perforation with conservative medical therapy case report(Turkiye Klinikleri Journal of Medical Sciences, 2011) Demirel, Ulvi; Harputoğlu, Muhsin Murat Muhip; Yağmur, Murat; Seçkin, Yüksel; Işık, Burak; Aladağ, MuratABS TRACT Behçet’s disease is a multisystem disorder. Intestinal involvement is common in patients from the Far East, but is rare among those from the Middle East. The most frequent area of involvement is the ileocecal region. Although intestinal perforations of Behçet’s disease are most frequently seen in the cecum, perforations of the sigmoid and descending colon have also been reported in the literature. A 45-year-old man with Behçet’s disease admitted to our hospital with abdominal pain and active lower gastrointestinal bleeding. A colonoscopic examination revealed multiple perforated ulcers in the descending colon. He was followed-up conservatively, and no surgical intervention was required. Descending-colon perforation is a rare complication of Behçet’s disease. Our patient recovered with conservative medical treatment, without surgery. Therefore, this case suggests that medical treatment with close follow-up may be useful in the management of intestinal perforations in Behçet’s disease.Öğe An Uncommon Presentation in Behcet's Disease: Recovered Descending-Colon Perforation with Conservative Medical Therapy: Case Report(Ortadogu Ad Pres & Publ Co, 2011) Demirel, Ulvi; Harputluoglu, Murat M.; Yagmur, Murat; Seckin, Yuksel; Isik, Burak; Aladag, MuratBehcet's disease is a multisystem disorder. Intestinal involvement is common in patients from the Far East, but is rare among those from the Middle East. The most frequent area of involvement is the ileocecal region. Although intestinal perforations of Behcet's disease are most frequently seen in the cecum, perforations of the sigmoid and descending colon have also been reported in the literature. A 45-year-old man with Behcet's disease admitted to our hospital with abdominal pain and active lower gastrointestinal bleeding. A colonoscopic examination revealed multiple perforated ulcers in the descending colon. He was followed-up conservatively, and no surgical intervention was required. Descending-colon perforation is a rare complication of Behcet's disease. Our patient recovered with conservative medical treatment, without surgery. Therefore, this case suggests that medical treatment with close follow-up may be useful in the management of intestinal perforations in Behcet's disease.
