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Öğe Detection of extended spectrum beta-lactamases and antibiotic susceptibilities of Klebsiella pneumoniae strains(2001) Tekereko?lu M.S.; Ayan M.; Otlu B.; Taştekin N.; A?el H.E.; Durmaz B.; Özerol I.H.One hundred Klebsiella pneumoniae strains isolated from various clinical specimens were investigated for the presence of extended spectrum beta-lactamases (ESBL) and the antimicrobial susceptibility patterns. The ESBL production was detected in 44% of strains isolated from inpatients and 14% of strains isolated from outpatients. The antimicrobial susceptibility rates of the total 100 strains and ESBL positive 58 strains were found to be as follows respectively: Cephalotin and cefuroxime 40% and 0%, cefoxitin 78% and 100%, ceftazidime 48% and 20%, cefotaxime 56% and 20%, ceftriaksone 52% and 18%, gentamicin 66% and 40%, amikacin 70% and 65%, ciprofloxacin 88% and 90%, imipenem 80% and 90%, meropenem 100% and 100%, aztreonam 50% and 30%, amoxicillin-clavulonic acid 28% and 10%, and trimethoprimsulphametoxazole 72% and 40 percent. The results indicated that ciprofloxacin, imipenem and meropenem might be used in the therapy of infections due to K. pneumoniae.Öğe Enterotoxigenic Bacteroides fragilis as a factor in diarrhea(2002) Durmaz B.The etiology of almost half of the diarrheal diseases has not been cleared yet, in spite of modern diagnostic methods. Bacteroides fragilis strains which secrete an enterotoxin are termed as enterotoxigenic B.fragilis (ETBF). These strains are associated with diarrheal diseases in children above 1 year of age and in adults. B. fragilis toxin (BFT) stimulates intestinal secretion and in-vitro cytotoxic response in HT29/C1 cells. Recent studies suggest that BFT is related to inflammatory bowel disease and colon cancer by triggering nuclear activation with potential oncogene expression. In this review, the molecular pathogenesis, epidemiology and laboratory diagnosis of ETBF have been reviewed to focus on ETBF as a diarrheal agent.Öğe Enzymatic profiles of prevotella, porphyromonas, and bacteroides species obtained with the API ZYM system and Rosco diagnostic tablets(1995) Durmaz B.; Jousimies-Somer H.R.; Finegold S.M.[No abstract available]Öğe Haemophilus aphrophilus brain abscess in the first decade(Medknow Publications and Media Pvt. Ltd, 2005) Bayraktar M.; Onal C.; Durmaz B.; Yakinci C.; Sonmezgoz E.This report presents a case of brain abscess due to Haemophilus aphrophilus in a six-year old boy. He was admitted to our hospital suffering from left-sided weakness. The initial radiological diagnosis was an intracranial abscess. Purulent material was obtained by puncturing the subcortical lesion and the sample was cultured on conventional media. H. aphrophilus was isolated in pure culture, identified according to conventional methods and confirmed by Becton Dickinson Laboratory (BBL) crystal system. After surgical drainage and eight weeks of antibiotic therapy, the neurological findings improved. The presented case is an example of H. aphriphilus causing brain abscess in the first decade without cardiac predisposition and with good outcome.Öğe HBsAg positivity in patients with prediagnosed viral hepatitis and hospital personnel(1991) Durmaz R.; Durmaz B.HBsAg was determined in 172 sera from 106 persons with clinically pre-diagnosed viral hepatitis (Group I) and 66 hospital personnel (Group II). In the investigation, the passive haemagglutination test was used. Positive results were obtained in 29.2% of Group I and 7.6% of Group II. HBsAg positivity in two groups was found to be differ significantly.Öğe Öğe Investigation of glycopeptide resistance in enterococcal strains isolated from Malatya, Kayseri and Elazi? Medical Faculty Hospitals(2001) Ersoy Y.; Sönmez E.; Young H.J.; A?el E.; Durmaz B.Enterococci are now receiving increased attention because of their resistance to multiple antimicrobial drugs, which probably explain their importance in nosocomial infections. The incidence of glycopeptide resistance of enterococci and detailed information about resistance genes has not yet been well recognized in our country. The aim of this study was to investigate the phenotypic and genotypic resistance of enterococci to glycopeptides, which were isolated from clinical specimens of patients in Medical Faculty Hospitals of Malatya, Kayseri and Elazi? Universities between the period from January 1998 to September 1999. A total of 235 enterococcus strains were included to the study and MIC values of vancomycin and teicoplanin for all isolates were determined by agar dilution method. All isolates were found to be susceptible to teicoplanin, but 11 strains showed intermediate resistance to vancomycin (4?g/ml?MIC?12?g/ml), while others were all susceptible. The vancomycin resistance genes of these 11 strains were investigated by single step polymerase chain reaction. As a result, vanC genes were detected in 7 strains and vanC2-3 genes in 2 strains, while there were no resistance genes in the other 2 isolates. In none of the strains vanB genes were positive. In conclusion, it has been suggested that the incidence of vancomycin resistance of enterococci in our region is not as high as in the other countries.Öğe Seropositivity of toxoplasmosis among reproductive-age women in Malatya, Turkey.(1995) Durmaz R.; Durmaz B.; Tas I.; Rafiq M.A total of 996 sera from women between the ages of 17-45 years were examined for Toxoplasma gondii; IgG and IgM antibodies by solid-phase-enzyme immunoassay. The overall prevalence of toxoplasmosis was found to be 39.9%. Of 996 women, 396 (39.6%) had specific IgG, 26 (2.6%) had both IgG and IgM, and 3 (0.3%) had only IgM antibodies. The results obtained in this study & other previous studies done in Turkey indicated the high prevalence of T. gondii infection in this country.Öğe Use of transcription-based amplification and enzyme immunoassay methods to investigate possible Chlamydia trachomatis infections in women with genital complaints(2002) Bulut Y.; Durmaz B.; Durmaz R.; Otlu B.This study was performed to determine the prevalence of Chlamydia trachomatis infections in the female patients with genital complaints, and to compare the transcription mediated amplification assay and enzyme immunoassay methods for the diagnosis of genital C. trachomatis infections. C. trachomatis (Ct) antigens and ribosomal RNAs were researched by enzyme immunoassay (EIA) and transcription-mediated amplification (TMA) assay, respectively in the endocervical swab samples of 90 patients. C. trachomatis IgG and IgM antibodies were also screened in the sera of these subjects, by EIA method. Of 90 patients, 18 (20%) were found to be positive for Ct-rRNA, 12 (13%) for Ct-antigen, 20 (22%) for IgG, 12 (13%) for IgM and 14 (16%) for both IgG and IgM. Among the patients 11 (12%) were found positive for Ct-antigen, Ct-rRNA and Ct-IgM antibodies. According to the TMA results, the sensitivity and specificity of EIA-Ct antigen method were estimated as 67% and 100%, respectively. There was statistically significant difference between TMA positivity and those of two EIA methods. In conclusion, the positive results obtained with EIA are reliable for the diagnosis of genital C. trachomatis infections, however the negative results should be confirmed by TMA.
