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    The alterations in serum ghrelin and leptin levels after intracerebroventricularly irisin infusion in rats
    (Wiley-Blackwell, 2015) Tekin, Suat; Erden, Yavuz; Sandal, Suleyman; Ozyalin, Fatma; Colak, Cemil
    [Abstract Not Available]
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    Antioxidant, Antimicrobial and Anticancer Activities of the Aspergillin PZ and Terphenyllin Secondary Metabolites: An in vitro Study
    (Gazi University Journal of Science, 2019) Erden, Yavuz; Tekin, Suat; Ceylan, Kevser Betül; Tekin, Çiğdem; Kırbağ, Sevda
    Öz: The importance of secondary metabolites obtained from fungi is increasing day by day in terms of human health. Many physiological and pharmacological effects, mainly antimicrobial, anticancer and antioxidant properties of these compounds have been reported. Aim of this study is to determine the anticancer, antioxidant and antimicrobial effects of aspergillin PZ and terphenyllin compounds, which are isolated from Aspergillus and also subjected to limited number of studies. The antimicrobial activity of aspergillin PZ and terphenyllin compounds was determined by using disc diffusion method using different bacteria. The antioxidant property of the compounds was determined by measuring the level of DPPH free radical scavenging. Cytotoxic activity was determined by experiments on human prostate cancer cell lines (PC3 and LNCaP) and over cancer cell line (A2780). Both compounds showed low antimicrobial activity on test bacteria (approximately 2-3 mm zone). High concentrations of applied compounds showed apparent DPPH free radical scavenging activity, while % scavenging activity was quite low at low concentrations. Both compounds showed significant anticancer activity on cancer cell lines (p <0.05). Our results suggest that these two compounds have important biological properties due to their antioxidant and anticancer activities.
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    Bazı önemli tıbbi bitkilerin antioksidan ve antikanser etkilerinin araştırılması
    (2019) Top, Rabia; Erden, Yavuz; Tekin, Yavuz; Tekin, Suat
    Öz: Tıbbi açıdan önemli bitkiler binlerce yıldır birçok hastalığın tedavisi amacıyla kullanılmaktadır. Buna ek olarakmodern eczacılıkta birçok bitki bileşiği ilaç ham maddesi veya yeni ilaçların yapımında önemli bir yere sahiptir.Bu çalışmada tıbbi öneme sahip kudret narı (Momordica charantia), pepino (Solanum muricatum) ve altın çilek(Physalis peruviana) bitkilerinin meyvelerinden elde edilen özütlerin biyolojik etkinliklerinin ortaya konulmasıamaçlanmıştır. Bitkilerin meyve özütleri %80’lik etanolde hazırlandıktan sonra toplam polifenol içeriği FolinCiocalteu reaktifi kullanılarak spektrofotometrik olarak ölçüldü. Bitki örneklerinin serbest radikal giderme etkisiDPPH serbest radikali kullanılarak belirlendi. Özütlerin insan over ve meme kanseri hücre hatları (sıyasıyla A2780 ve MCF-7) üzerine sitotoksik etkileri MTT yöntemi kullanılarak belirlendi. Bitki örneklerindeki toplampolifenolik düzeyin en düşük 138,14±12,15 ve en yüksek 415,71±36,89 µg/gr gallik asit düzeyinde olduğubelirlendi. Bütün özütlerin düşük seviyede antioksidan etki sergilediği saptandı. Son olarak over ve meme kanserihücre serilerine uygulanan özütlerin güçlü sitotoksik etki gösterdiği belirlendi (p<0.05). Sonuçta her üç bitkiörneğinin de antioksidan etkilerinden ziyade yüksek antikanser etkiye sahip olduğunu bizlere göstermektedir. Herüç örneğinde söz konusu kanser türleri üzerine etkilerini aydınlatmak için ileriki çalışmalara ihtiyaç vardır.
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    Beyindeki Mitokondriyal Eşleşme Bozucu Proteinler: Yapısı, İşlevi Ve Fizyolojik Rolleri
    (2015) Erden, Yavuz; Kırbağ, Sevda; Sandal, Süleyman
    Öz: Mitokondriyal anyon taşıyıcı protein ailesinden olan eşleşme bozucu proteinler (UCP), farklı dokulara özgü dağılımları ve bu dokulardaki kendilerine özgü fizyolojik işlevleri nedeniyle önemlidirler. Kahverengi yağ dokuda bulunan ve bu ailenin en tanınmış üyesi olan UCP1, enerji metabolizması ile vücut sıcaklığının düzenlenmesinde görev alır. UCP ailesinin diğer üyeleri (UCP2, UCP4 ve UCP5) nöronal alanda geniş yayılım gösterir. Nöronal UCP'ler merkezi sinir sisteminde nöroendokrin fonksiyonların düzenlenmesi, serbest radikal oluşumu, nöroproteksiyon ve sinaptik iletimde görev alırlar. Bu derlemenin amacı nöronal UCP'lerin sahip olduğu fizyolojik rollerin daha iyi anlaşılmasını sağlamaktır.
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    Cannabinoid type 2 receptor agonist JWH-133, attenuates Okadaic acid induced spatial memory impairment and neurodegeneration in rats
    (Pergamon-Elsevier Science Ltd, 2019) Cakir, Murat; Tekin, Suat; Doganyigit, Zuleyha; Erden, Yavuz; Soyturk, Merve; Cigremis, Yilmaz; Sandal, Suleyman
    Aim: Cannabinoid system has various physiological roles such as neurogenesis, synaptic plasticity and emotional state regulation in the body. The presence of cannabinoid type 2 receptor (CB2), a member of the cannabinoid system, was detected in different regions of the brain. CB2 receptor plays a role in neuroinflammatory and neurodegenerative processes. We aimed to determine the possible effect of CB2 agonist JWH-133 in Okadaic acid (OKA)-induced neurodegeneration model mimicking Alzheimer's Disease (AD) through tau pathology. Materials and methods: In this study, 40 Sprague Dawley male rats were divided into 4 groups (Control, Sham, OKA, OKA + JWH-133). Bilateral intracerebroventricular (icv) injection of 200 ng OKA was performed in the OKA group. In the OKA + JWH-133 group, injection of JWH-133 (0.2 mg/kg) was performed intraperitoneally for 13 days different from the group of OKA. Morris water maze test was used to evaluate the spatial memory. Levels of caspase-3, phosphorylated tau (ser396), amyloid beta (A beta), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) levels in brain cortex; and the hippocampus regions were examined by immunohistochemical methods. Key findings: In the OKA group, caspase-3, phosphorylated tau (ser396), A beta, IL-1 beta levels were higher in the cortex and hippocampus than in the other groups. The implementation of the JWH-133 reversed the increments in these parameters, and also prevented spatial memory impairment.
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    Central Application of Asprosin Increases Secretion of Male Reproductive Hormones: An In Vivo Study
    (Wiley, 2022) Keskin, Tuba; Erden, Yavuz; Tekin, Suat
    [Abstract Not Available]
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    Central irisin administration suppresses thyroid hormone production but increases energy consumption in rats
    (Elsevier Ireland Ltd, 2018) Tekin, Suat; Erden, Yavuz; Ozyalin, Fatma; Onalan, Ebru Etem; Cigremis, Yilmaz; Colak, Cemil; Tekedereli, Ibrahim
    Irisin, which is secreted from the skeletal muscle in response to physical exercise and defined as a thermogenic peptide, may play an important role in energy metabolism. Thyroid hormones, which are one of the other influential factors on the metabolic status, increase heat production and are the main regulators of energy metabolism. This study was conducted to determine the possible effects of irisin administration on thyroid hormones. Forty adult male Wistar albino rats were used in the study. The rats were equally divided into 4 groups (n = 10). The brain infusion kit was implanted in the groups, and irisin (or solvent as control) was centrally administered to the rats via osmotic mini pumps for 7 days. During the experiment, food consumption, body weights, and body temperatures of the animals were recorded. Food intake was significantly increased in the groups treated with irisin (p < 0.05), but their body weights were not changed. Hypothalamic TRH gene expression, serum TSH, fT3, and fT4 levels were significantly lower in the groups treated with irisin as compared to the naive and control groups (p < 0.05). In addition, irisin increased UCP1 mRNA expression in white and brown adipose tissue and UCP3 mRNA expression in muscle tissue in rats and also raised their body temperature (p < 0.05). Consequently, although central irisin administration has inhibitory effects on the hypothalamic-pituitary thyroid axis, it seems to be an important agent in the regulation of food intake and energy metabolism.
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    Central irisin administration suppresses thyroid hormone production but increases energyconsumption in rats
    (Elsevıer ıreland ltd, elsevıer house, brookvale plaza, east park shannon, co, clare, 00000, ıreland, 2018) Tekin, Suat; Erden, Yavuz; Ozyalin, Fatma; Cigremis, Yilmaz; Colak, Cemil; Tekedereli, Ibrahim; Sandal, Suleyman
    Irisin, which is secreted from the skeletal muscle in response to physical exercise and defined as a thermogenic peptide, may play an important role in energy metabolism. Thyroid hormones, which are one of the other influential factors on the metabolic status, increase heat production and are the main regulators of energy metabolism. This study was conducted to determine the possible effects of irisin administration on thyroid hormones. Forty adult male Wistar albino rats were used in the study. The rats were equally divided into 4 groups (n = 10). The brain infusion kit was implanted in the groups, and irisin (or solvent as control) was centrally administered to the rats via osmotic mini pumps for 7 days. During the experiment, food consumption, body weights, and body temperatures of the animals were recorded. Food intake was significantly increased in the groups treated with irisin (p < 0.05), but their body weights were not changed. Hypothalamic TRH gene expression, serum TSH, fT3, and fT4 levels were significantly lower in the groups treated with irisin as compared to the naive and control groups (p < 0.05). In addition, irisin increased UCP1 mRNA expression in white and brown adipose tissue and UCP3 mRNA expression in muscle tissue in rats and also raised their body temperature (p < 0.05). Consequently, although central irisin administration has inhibitory effects on the hypothalamic-pituitary thyroid axis, it seems to be an important agent in the regulation of food intake and energy metabolism.
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    Central MOTS-c infusion affects reproductive hormones in obese and non-obese rats
    (Elsevier Ireland Ltd, 2024) Ozturk, Dilara Altay; Erden, Yavuz; Tekin, Suat
    MOTS-c, a mitochondrial-derived peptide, acts as a systemic hormone and MOTS-c level is inversely correlated with markers of obesity. Obesity is a risk factor for male reproductive physiology and is expressed as an important cause of infertility. In this study, we aimed to determine the effects of MOTS-c, which has been proven in the hypothalamus and testicles, on the actors involved in the reproductive axis. In the study, 80 male Wistar-Albino rats were divided into two main groups, obese and non-obese (n = 40). Rats in the first main group were fed with fatty diet feed and obesity was induced. The second main group was fed with normal diet feed. Each main group was divided into 4 subgroups (Control, Sham, 10 and 100 mu M MOTS-c). The lateral ventricles of the animals in the treatment groups were infused with 10 and 100 mu M MOTS-c (solvent in Sham group) for 14 days. At the end of the experiment, hypothalamic Gonadotropin-Releasing Hormone (GnRH) gene expression level, serum testosterone, Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) levels were determined. MOTS-c infusion caused an increase in GnRH mRNA, protein expression levels and serum testosterone, LH and FSH levels in obese and non-obese rats (p < 0.05). MOTS-c administration more significantly upregulated hormone levels in non-obese rats (p < 0.05). MOTS-c administration increases these hormones, suggesting that MOTS-c may stimulate the reproductive axis. Our results reveal that MOTS-c plays a role in the central regulation of reproduction, as well as causes increased LH, FSH and testosterone release.
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    Central MOTS-c Infusion in Obese and Non-obese Rats Increases Reproductive Hormones Secretion
    (Wiley, 2022) Ozturk, Dilara Altay; Erden, Yavuz; Tekin, Suat
    [Abstract Not Available]
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    Does Irisin Affect Uncoupling Protein Levels in Fat and Muscle Tissues?
    (Wiley-Blackwell, 2016) Tekin, Suat; Sandal, Suleyman; Erden, Yavuz; Onalan, Ebru Etem; Colak, Cemil
    [Abstract Not Available]
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    Effect of Cannabinoid Type 2 Receptor Activation in Okadaic Acid Induced Rat Alzheimer's Disease Model
    (Wiley, 2018) Cakir, Murat; Doganyigit, Zuleyha; Tekin, Suat; Erden, Yavuz; Cigremis, Yilmaz; Sandal, Suleyman
    [Abstract Not Available]
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    Effect of cannabinoid type 2 receptor activation in okadaic acid ınduced rat alzheimer's disease model
    (Acta physıologıca, 2018) Çakır, Murat; Doğanyiğit, Züleyha; Tekin, Suat; Erden, Yavuz; Cigremis, Yilmaz; Sandal, Suleyman
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    Effect of Intracerebroventricular Administration of Apelin-13 on the Hypothalamus-Pituitary-Thyroid Axis and Peripheral Uncoupling Proteins
    (Springer, 2018) Erden, Yavuz; Tekin, Suat; Tekin, Cigdem; Ozyalin, Fatma; Yilmaz, Umit; Onalan, Ebru Etem; Cigremis, Yilmaz
    Apelin, a ligand for G protein-coupled APJ receptor, is a peptide hormone. Although apelin and APJ receptors are determined in hypothalamus and thyroid gland its role in the hypothalamus-pituitary-thyroid (HPT) axis and mechanism of action on energy metabolism is not clear. This suggests that apelin may play a role in the HPT axis and energy metabolism. This study was designed to determine possible effects of centrally administered apelin-13 on the HPT axis and energy metabolism. A total of 40 adult male Sprague Dawley rats were divided into four groups (n=10 each group). Intact rats served as control group while the sham group received vehicle of apelin. Apelin-13 was injected intracerebroventricularly at the doses of 1 and 10nmol, for 7 days in the rats in the experimental group. At the end of the experimental protocol, animals were decapitated and brain, blood, white and brown adipose tissues samples were collected. There was no significant difference between the groups in terms of hypothalamic TRH mRNA levels. Serum TSH levels were significantly higher in all groups compared to the control group (p<0.05). Serum fT3 and fT4 levels were significantly lower in apelin-13 administered groups (p<0.05). Moreover, apelin-13 administered groups had lower levels of UCP1 mRNA in white and brown adipose tissues. UCP3 mRNA expression in muscle tissue was also lower in apelin-13 treated groups (p<0.05). These results indicates that apelin-13 exhibits a decreasing effect on energy consumption through a mechanism involving the peripheral rather than central arms of the HPT axis.
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    Effect of ıntracerebroventricular administration of apelin-13 on the hypothalamus-pituitary-thyroid axis and peripheral uncoupling proteins
    (Internatıonal journal of peptıde research and therapeutıcs, 2018) Erden, Yavuz; Tekin, Cigdem; Ozyalin, Fatma; Yilmaz, Umit; Tekin, Suat
    Apelin, a ligand for G protein-coupled APJ receptor, is a peptide hormone. Although apelin and APJ receptors are determined in hypothalamus and thyroid gland its role in the hypothalamus-pituitary-thyroid (HPT) axis and mechanism of action on energy metabolism is not clear. This suggests that apelin may play a role in the HPT axis and energy metabolism. This study was designed to determine possible effects of centrally administered apelin-13 on the HPT axis and energy metabolism. A total of 40 adult male Sprague Dawley rats were divided into four groups (n=10 each group). Intact rats served as control group while the sham group received vehicle of apelin. Apelin-13 was injected intracerebroventricularly at the doses of 1 and 10nmol, for 7 days in the rats in the experimental group. At the end of the experimental protocol, animals were decapitated and brain, blood, white and brown adipose tissues samples were collected. There was no significant difference between the groups in terms of hypothalamic TRH mRNA levels. Serum TSH levels were significantly higher in all groups compared to the control group (p<0.05). Serum fT3 and fT4 levels were significantly lower in apelin-13 administered groups (p<0.05). Moreover, apelin-13 administered groups had lower levels of UCP1 mRNA in white and brown adipose tissues. UCP3 mRNA expression in muscle tissue was also lower in apelin-13 treated groups (p<0.05). These results indicates that apelin-13 exhibits a decreasing effect on energy consumption through a mechanism involving the peripheral rather than central arms of the HPT axis.
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    Effects of apelin on reproductive functions: relationship with feeding behavior and energy metabolism
    (Taylor & Francis Ltd, 2017) Tekin, Suat; Erden, Yavuz; Sandal, Suleyman; Onalan, Ebru Etem; Ozyalin, Fatma; Ozen, Hasan; Yilmaz, Bayram
    Apelin is an adipose tissue derived peptidergic hormone. In this study, 40 male Sprague-Dawley rats were used (four groups; n=10). Apelin-13 at three different dosages (1, 5 and 50g/kg) was given intraperitoneally while the control group received vehicle the same route for a period of 14 days. In results, apelin-13 caused significant decreases in serum testosterone, luteinizing hormone and follicle-stimulating hormone levels (p<0.05). Administration of apelin-13 significantly increased body weights, food intake, serum low-density lipoprotein and total cholesterol levels (p<0.05), but caused significant decreases in high-density lipoprotein levels (p<0.05). Serum glucose and triglyceride levels were not significantly altered by apelin-13 administration. Significant decreases in both uncoupling protein (UCP)-1 levels in the white and brown adipose tissues and UCP-3 levels in the biceps muscle (p<0.05) were noted. The findings of the study suggest that apelin-13 may not only lead to obesity by increasing body weight but also cause infertility by suppressing reproductive hormones.
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    The Effects of Apelin-13 on Puberty in Female Rats
    (Wiley-Blackwell, 2015) Erden, Yavuz; Tekin, Suat; Ozyalin, Fatma; Ozen, Hasan; Colak, Cemil; Sandal, Suleyman
    [Abstract Not Available]
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    Effects of Central Infusion of Irisin on the Energy Metabolism and Glucose Uptake in Rats
    (Karger, 2018) Erden, Yavuz; Tekin, Suat; Caglayan, Ahmet Burak; Ozyalin, Fatma; Cigremis, Yilmaz; Colak, Cemil; Sandal, Suleyman
    [Abstract Not Available]
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    Effects of central irisin administration on the uncoupling proteins in rat brain
    (Elsevier Ireland Ltd, 2016) Erden, Yavuz; Tekin, Suat; Sandal, Suleyman; Onalan, Ebru Etem; Tektemur, Ahmet; Kirbag, Sevda
    Irisin is a thermogenic peptide that enables the development of brown adipose tissue from white adipose tissue by activating the UCP1. This study has been designed to determine the effects of the irisin on UCPs. Sprague Dawley female rats were used in the study. 1, 3 and 10 mu M concentrations of irisin were injected intracerebroventricularly to the rats, and the control group was received only vehicle. The animals were killed at the 16, 24, and 48 h time intervals and their brains were taken out. The hypothalamus, pituitary gland, hippocampus, cerebellum, striatum and cortex areas were separated and the UCP2, UCP3, UCP4 and UCP5 mRNA levels were determined. Just before the animals were killed, their body temperatures were recorded. It was observed that after application of the high dose irisin, UCP5 mRNA level in the all brain areas increased (p < 0.05); it was also observed that the three doses decreased the UCP4 expression in all brain areas (except the pituitary gland; p < 0.05). The UCP2 and UCP3 mRNA expressions showed significantly increase in cerebellum and striatum (p < 0.05). The UCP2 mRNA expression decreased in hypothalamus, pituitary gland, hippocampus and cortex areas (p < 0.05). It was also observed that the body temperatures of the rats increased depending on the irisin injection and this increase was the most considerable at the 24h (p < 0.05). The results of this study suggest that the UCP2-5 is expressed in different areas of the brain, and the irisin affects this expression, and may have effective roles in some brain functions. (C) 2016 Elsevier Ireland Ltd. All rights reserved.