Antioxidant, Antimicrobial and Anticancer Activities of the Aspergillin PZ and Terphenyllin Secondary Metabolites: An in vitro Study
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gazi University Journal of Science
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Öz: The importance of secondary metabolites obtained from fungi is increasing day by day in terms of human health. Many physiological and pharmacological effects, mainly antimicrobial, anticancer and antioxidant properties of these compounds have been reported. Aim of this study is to determine the anticancer, antioxidant and antimicrobial effects of aspergillin PZ and terphenyllin compounds, which are isolated from Aspergillus and also subjected to limited number of studies. The antimicrobial activity of aspergillin PZ and terphenyllin compounds was determined by using disc diffusion method using different bacteria. The antioxidant property of the compounds was determined by measuring the level of DPPH free radical scavenging. Cytotoxic activity was determined by experiments on human prostate cancer cell lines (PC3 and LNCaP) and over cancer cell line (A2780). Both compounds showed low antimicrobial activity on test bacteria (approximately 2-3 mm zone). High concentrations of applied compounds showed apparent DPPH free radical scavenging activity, while % scavenging activity was quite low at low concentrations. Both compounds showed significant anticancer activity on cancer cell lines (p <0.05). Our results suggest that these two compounds have important biological properties due to their antioxidant and anticancer activities.
Açıklama
Yıl: 2019Cilt: 32Sayı: 3ISSN: 2147-1762 / 2147-1762Sayfa Aralığı: 792 - 800Metin Dili:İngilizce
Anahtar Kelimeler
Kaynak
Gazi University Journal of Science
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
32
Sayı
3
Künye
ERDEN Y,TEKİN S,CEYLAN K. B,TEKİN Ç,KIRBAĞ S (2019). Antioxidant, Antimicrobial and Anticancer Activities of the Aspergillin PZ and Terphenyllin Secondary Metabolites: An in vitro Study. Gazi University Journal of Science, 32(3), 792 - 800. Doi: 10.35378/gujs.467166
