Antioxidant, Antimicrobial and Anticancer Activities of the Aspergillin PZ and Terphenyllin Secondary Metabolites: An in vitro Study

Basit Öğe Kaydı
dc.contributor.authorErden, Yavuz
dc.contributor.authorTekin, Suat
dc.contributor.authorCeylan, Kevser Betül
dc.contributor.authorTekin, Çiğdem
dc.contributor.authorKırbağ, Sevda
dc.date.accessioned2020-12-08T08:17:39Z
dc.date.available2020-12-08T08:17:39Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.descriptionYıl: 2019Cilt: 32Sayı: 3ISSN: 2147-1762 / 2147-1762Sayfa Aralığı: 792 - 800Metin Dili:İngilizceen_US
dc.description.abstractÖz: The importance of secondary metabolites obtained from fungi is increasing day by day in terms of human health. Many physiological and pharmacological effects, mainly antimicrobial, anticancer and antioxidant properties of these compounds have been reported. Aim of this study is to determine the anticancer, antioxidant and antimicrobial effects of aspergillin PZ and terphenyllin compounds, which are isolated from Aspergillus and also subjected to limited number of studies. The antimicrobial activity of aspergillin PZ and terphenyllin compounds was determined by using disc diffusion method using different bacteria. The antioxidant property of the compounds was determined by measuring the level of DPPH free radical scavenging. Cytotoxic activity was determined by experiments on human prostate cancer cell lines (PC3 and LNCaP) and over cancer cell line (A2780). Both compounds showed low antimicrobial activity on test bacteria (approximately 2-3 mm zone). High concentrations of applied compounds showed apparent DPPH free radical scavenging activity, while % scavenging activity was quite low at low concentrations. Both compounds showed significant anticancer activity on cancer cell lines (p <0.05). Our results suggest that these two compounds have important biological properties due to their antioxidant and anticancer activities.en_US
dc.identifier.citationERDEN Y,TEKİN S,CEYLAN K. B,TEKİN Ç,KIRBAĞ S (2019). Antioxidant, Antimicrobial and Anticancer Activities of the Aspergillin PZ and Terphenyllin Secondary Metabolites: An in vitro Study. Gazi University Journal of Science, 32(3), 792 - 800. Doi: 10.35378/gujs.467166en_US
dc.identifier.doi10.35378/gujs.467166en_US
dc.identifier.endpage800en_US
dc.identifier.issn2147-1762
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85073431664en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage792en_US
dc.identifier.trdizinid324610en_US
dc.identifier.urihttps://doi.org/10.35378/gujs.467166
dc.identifier.urihttps://hdl.handle.net/11616/19048
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/324610
dc.identifier.volume32en_US
dc.identifier.wosWOS:000484025600003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherGazi University Journal of Scienceen_US
dc.relation.ispartofGazi University Journal of Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAntioxidant, Antimicrobial and Anticancer Activities of the Aspergillin PZ and Terphenyllin Secondary Metabolites: An in vitro Studyen_US
dc.typeArticleen_US

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