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Öğe Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children(J Cardiovasc Med 2013, 14:228–234., 2013) Akıncı, Ayşehan; Karakurt, Cemşit; Gürbüz, Sibel; Elkıran, Özlem; Nalbantoğlu, Özlem; Koçak, Gülemdar; Güldür, Tayfun; Yoloğlu, SaimObjectives To investigate serum adiponectin and resistin levels in childhood obesity and their relationship with cardiac changes and insulin resistance. Methods Seventy-one obese and 24 overweight children and 40 healthy children and adolescents were selected for the study. Height and weight measurements, BMI values and BMI SD score values were obtained for each individual. After blood pressure measurement, left ventricular wall thickness, left ventricular mass, stroke volume, cardiac output, systolic and diastolic functions of the left ventricle were measured using an M-mode, two dimensional colorcoded echocardiography device. Blood samples of the individuals were obtained for fasting blood sugar, total blood cholesterol, triglyceride, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein cholesterol, highdensity lipoprotein cholesterol, insulin, C-peptide, adiponectin and resistin values. Results Cholesterol and LDL values, homeostasis model assessment of insulin resistance, fasting insulin and fasting C-peptide values of the obese and overweight groups were higher (P< 0.01). Adiponectin level (P< 0.001) and resistin level (P< 0.05) of the obese and overweight groups were lower than those of the control group (P< 0.05). Echocardiographic evaluation showed diastolic dysfunction in addition to increased left ventricular wall thickness and left ventricle mass values in the obese and overweight children. We also detected a significant positive correlation among left ventricular mass, interventricular septum systolic diameter and resistin in obese children. Among the factors, resistin level was determined as an independent predictor of left ventricular mass in obese children. Conclusion In this study, even in asymptomatic obese and overweight children, cardiac structural and functional changes, such as increased left ventricular mass and diastolic dysfunction, were demonstrated. Although decreased adiponectin level was not related to cardiac changes, it was shown that decreased serum resistin levels in the obese cases lead to left ventricle hypertrophy.Öğe Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children(Journal of Cardiovascular Medicine, 2013) Akıncı, Ayşehan; Karakurt, Cemsit; Gürbüz, Sibel; Elkıran, Özlem; Nalbantoğlu, Özlem; Kocak, Gulendam; Güldür, Tayfun; Yoloğlu, SaimObjectives To investigate serum adiponectin and resistin levels in childhood obesity and their relationship with cardiac changes and insulin resistance. Methods Seventy-one obese and 24 overweight children and 40 healthy children and adolescents were selected for the study. Height and weight measurements, BMI values and BMI SD score values were obtained for each individual. After blood pressure measurement, left ventricular wall thickness, left ventricular mass, stroke volume, cardiac output, systolic and diastolic functions of the left ventricle were measured using an M-mode, two dimensional colorcoded echocardiography device. Blood samples of the individuals were obtained for fasting blood sugar, total blood cholesterol, triglyceride, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein cholesterol, highdensity lipoprotein cholesterol, insulin, C-peptide, adiponectin and resistin values. Results Cholesterol and LDL values, homeostasis model assessment of insulin resistance, fasting insulin and fasting C-peptide values of the obese and overweight groups were higher (P<0.01). Adiponectin level (P<0.001) and resistin level (P<0.05) of the obese and overweight groups were lower than those of the control group (P<0.05). Echocardiographic evaluation showed diastolic dysfunction in addition to increased left ventricular wall thickness and left ventricle mass values in the obese and overweight children. We also detected a significant positive correlation among left ventricular mass, interventricular septum systolic diameter and resistin in obese children. Among the factors, resistin level was determined as an independent predictor of left ventricular mass in obese children. Conclusion In this study, even in asymptomatic obese and overweight children, cardiac structural and functional changes, such as increased left ventricular mass and diastolic dysfunction, were demonstrated. Although decreased adiponectin level was not related to cardiac changes, it was shown that decreased serum resistin levels in the obese cases lead to left ventricle hypertrophy.Öğe Biyofilm oluşturan ve oluşturmayan staphylococcus aureus klinik izolatlarının hidrofobik özelliklerinin araştırılması(2010) Ay, Selma; Güldür, Tayfun; Tekerekoğlu, Mehmet Sait; Otlu, BarışÖz: Stafilokok enfeksiyonlarının patogenezinde, stafilokokların yabancı cisim yüzeylerine yapışma ve bu yüzeylerde biyofilm (slime) oluşturma yetenekleri rol oynamaktadır. Yüzeye bağlanmada mikroorganizma ile yüzey arasındaki hidrofobik etkileşimler ve hidrojen bağları da önemlidir. Bu çalışmada, biyofilm oluşturan ve oluşturmayan Staphylococcus aureus klinik izolatlarının hidrofobik özelliklerinin araştırılması amaçlanmıştır. Çalışmaya, Mayıs 2006-Haziran 2007 tarihleri arasında yoğun bakım ünitesinde yatmakta olan hastaların kan kültürlerinden izole edilen, tümü metisiline dirençli ve 5’i biyofilm oluşturan 10 S.aureus suşu dahil edilmiştir. Çalışmada standart suş olarak S.aureus ATCC 25923 kullanılmış; “slime” üretimi Christensen yöntemi ile, metisilin direnci sefoksitin disk difüzyon ve oksasilin tuz agar tarama testi ile belirlenmiş ve suşların hiçbirisinin otoagregasyon göstermediği saptanmıştır. İzolatların hidrofobik yüzeylere yapışma özelliği, hidrofobik etkileşim kromatografisi (HIC; Hydrophobic Interaction Chromatography) ile araştırılmış ve HIC yönteminde katı faz olarak üç farklı hidrokarbon (bütil-sefaroz, oktil-sefaroz ve fenil-sefaroz; Amersham Bioscience, İsveç) kullanılmıştır. Çalışmamızda, biyofilm oluşturan izo- latların bütil- ve oktil-sefaroz ile kromatografisi sonunda iki fraksiyona (sırasıyla; %40 ve %96 etanol); oluşturmayan suşların ise üç fraksiyona [sırasıyla; fosfat tamponu (PBS), %40 ve %96 etanol] ayrıldığı saptanmıştır. Buna karşın “slime” pozitif ve negatif S.aureus suşlarının fenisefaroz kromatografisi sonunda iki fraksiyon (sırasıyla; %40 ve %96 etanol) elde edilmiştir. Hidrofobisite çalışmalarında, ortamın pH ve ısı değişimlerinin sonuçlar üzerindeki etkisinin araştırılması amacıyla da, tüm işlemler 4°C’de ve pH 6-9 arası değerlerde tekrarlanmış ve bu ısı ve pH değerlerinde kromatografik paternlerin değişmediği görülmüştür. Sonuç olarak, biyofilm oluşturan S.aureus izolatlarının, oluşturmayan izolatlara göre daha hidrofobik olduğu belirlenmiştir. Ayrıca verilerimiz, saf S.aureus kültürleri içerisinde dahi farklı hidrofobik bağlanma kuvvetine sahip heterojen fraksiyonlar bulunabileceğini ve bu heterojen fraksiyonlar arasında hidrofobik yüzey proteinlerinin salgılanma derecelerinin farklı olabileceğini düşündürmüştür. Ancak, farklı fraksiyonlarda yer alan suşların daha iyi karakterize edilmesi ve enfeksiyon oluşturma yeteneklerinin ortaya konması için ileri çalışmalara gereksinim vardır.Öğe Circadian rhythm in mammals time to eat time to sleep(Biological Rhythm Research, 2016) Güldür, Tayfun; Otlu, Hüsniye GülCircadian rhythm is defined as rhythmic fluctuations in physiological processes which enable living organisms to make necessary arrangements for upcoming changes in the environment thereby optimizing their metabolism. Mammalian circadian clock consists of feedback(negative) and feedforward (positive) loops consisting of transcription, translation and posttranslational events. It is believed that there are two kinds of clock functioning in the body.The master clock residing in hypothalamus oscillating in conjunction with light/ dark cycle whereas peripheral clocks occur in peripheral tissues and influenced by other environmental factors such as feeding. The rhythmic alterations in activities of metabolic pathways are provided by the coordinated expressions of clock genes and consequently by clock-controlled genes. The current studies indicate that consumption of food at inappropriate times as well as sleep restrictions lead to metabolic dysfunctions due to disruption of circadian rhythm which result in diabetes, obesity and heart diseases. To this end, it is aimed, in this review, to examine interactions among food or sleep, metabolism and circadian rhythm with an insight into metabolomic profiling studies of circadian disturbances by sleep restrictions following an overview of working mechanisms of circadian rhythms in mammals.Öğe Effects of interactions between various fats and active passive phases on postprandial inflammation in rats(Biological Rhythm Research, 2016) Otlu, Hüsniye Gül; Kayhan, Başak; Güldür, TayfunThe circadian clock controls number of behavioral and physiological processes during daily light/dark cycle including inflammation and vascular injury. However, how reciprocal interaction of dietary fats and light/dark cycle affects postprandial inflammation is currently unknown. To this end, effects of various dietary fats given to rats by gavaging either in light or dark phase on postprandial inflammation were compared. Sunflower oil load activated greater number of inflammatory CD markers in passive phase whereas the butter load in active phase compared to their counter phase. The inflammatory influence of fish oil load appeared to be mostly confined to passive phase. Differences found between the levels of some of the inflammatory markers in active and passive phases of normal fed rats were altered by fat/oil administrations. We conclude that influences of dietary fats/oils on postprandial inflammatory changes might depend not only on their fatty acid compositions but also on their ingestion times.Öğe Effects of reciprocal interactions between various dietary fats and circadian phases on postprandial hyperlipidemia in rats(Biological Rhythm Research, 2017) Satılmış, Basri; Kayhan, Başak; Güldür, TayfunExpression levels of various intestinal proteins involved in postprandial lipoprotein assembly as well as plasma triglyceride concentration exhibit daily oscillations indicating circadian control. The length of the carbon chain and degree and position of unsaturation of fatty acids influence triglyceride secretion by the enterocytes. To this end, effects of reciprocal interactions of various single fats/oil (olive oil, fish oil or butter) gavaging either in active or passive phase were investigated in rats. Fat/oil gavaged in the active phase of circadian rhythm resulted in higher postprandial serum triglyceride levels compared to that in the passive phase. Moreover, olive oil led to higher MTP activity and apo B-48 gene expression, while fish oil gavaging caused more prominent apo B-48 and MTP gene expression when they were given in the passive phase. The present results indicate that circadian time at which fat or oil gavaged once might exert influence on postprandial lipoprotein synthesis/assembly.Öğe Effects of reciprocal interactions between various dietary fats and circadian phases on postprandial hyperlipidemia in rats(TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND, 2018) Satılmış, Basri; Kayhan, Başak; Güldür, TayfunExpression levels of various intestinal proteins involved in postprandial lipoprotein assembly as well as plasma triglyceride concentration exhibit daily oscillations indicating circadian control. The length of the carbon chain and degree and position of unsaturation of fatty acids influence triglyceride secretion by the enterocytes. To this end, effects of reciprocal interactions of various single fats/oil (olive oil, fish oil or butter) gavaging either in active or passive phase were investigated in rats. Fat/oil gavaged in the active phase of circadian rhythm resulted in higher postprandial serum triglyceride levels compared to that in the passive phase. Moreover, olive oil led to higher MTP activity and apo B-48 gene expression, while fish oil gavaging caused more prominent apo B-48 and MTP gene expression when they were given in the passive phase. The present results indicate that circadian time at which fat or oil gavaged once might exert influence on postprandial lipoprotein synthesis/assembly.Öğe Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia(Turkish Journal of Medical Sciences, 2007) Güldür, Tayfun; Bayraktar, Nihayet; Kaynar, Özgür; Beker, Gülçin; Koçer, Muzaffer; Özcan, HamdiÖz: Amaç: Deri yüzey lipidlerinin çoğu sebum olarak adlandırılan yağlı bir maddeyi salgılayan yağ bezlerinden köken almaktadır. Sebum lipidlerinin bir kısmı yağ bezi hücreleri tarafından sentezlenirken diğer bir kısmının ise plazmadan kaynaklanabileceği bildirilmiştir. Kan lipoproteinlerinin sebum sekresyon hızı ve kompozisyonundaki rolü açık değildir. Bu amaçla, normo- ve tip IV hiperlipoproteinemili erişkin erkeklerde deri yüzey lipidlerinin ekskresyon hızı ve kompozisyonu karşılaştırıldı. Yöntem ve Gereç: Tip IV hiperlipoproteinemili (n: 21) ve normolipoproteinemililerde (n: 15) deri yüzey lipidlerinin kantitatif analizi, alnın sağ, sol ve orta bölgesinde yapılan sebumetrik ölçümlerle gerçekleştirildi. Deri yüzey lipidlerinin kompozisyonel analizi için numuneler alın bölgesinden n-hekzan ile ekstrakte edilerek elde edildi ve yüksek performanslı ince tabaka kromatografisi (HPTLC) ile analiz edildi. Bulgular: Tip IV hiperlipoproteinemili erişkin erkeklerde deri yüzey lipidlerinin normolipoproteinemililere göre daha yüksek oranda mum esteri + kolesteril esteri içerdiği tespit edildi (p: 0.004). Bununla beraber, ekskresyon hızlarında istatiksel olarak önemli bir fark tespit edilemedi. Sonuç: Plazma triaçilgliserol konsantrasyonu sebum mum esteri+kolesteril esteri içeriğini etkileyebilmektedir.Öğe Sıçanlarda farklı besinsel yağların postprandial inflamasyon etkilerinin sirkadiyen ritme göre karşılaştırılması(2013) Güldür, Tayfun[Abstract Not Available]
