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Öğe Ankaferd Blood Stopper Is More Effective Than Adrenaline Plus Lidocaine and Gelatin Foam in the Treatment of Epistaxis in Rabbits(Elsevier Science Inc, 2011) Kelles, Mehmet; Kalcioglu, M. Tayyar; Samdanci, Emine; Selimoglu, Erol; Iraz, Mustafa; Miman, Murat Cem; Haznedaroglu, Ibrahim C.BACKGROUND: Epistaxis is an important emergency that can sometimes be life threatening without effective intervention. Persistent and recurrent bleeding can lead to aspiration, hypotension, hypoxia, or even severe and mortal cardiovascular complications. Providing prompt hemostasis is important, and the hemostatic method used must be easily and locally applicable, efficient, and inexpensive. OBJECTIVE: The aim of this study was to assess the hemostatic efficacy of Ankaferd Blood Stopper (ABS) in an experimental epistaxis model and to determine the histopathologic alterations with topical ABS application. METHODS: Twenty-eight New Zealand rabbits were evaluated in 4 study groups. Topical ABS, gelatin foam (GF), adrenalin + lidocaine (AL), and serum physiologic as negative control (C) were applied to the animals for controlling epistaxis. The bleeding was generated with a standard mucosal incision in all groups. Cotton pieces soaked with ABS, AL, C, and GF were applied to the nasal bleeding area. Time of hemostasis was recorded. Tissue samples were obtained after hemostasis for histopathologic examination. The samples were stained with hematoxylin and eosin (HE) and phosphotungstic acid hematoxylin (PTAH) and were examined under a light microscope. In this experimental study, the observers were blind to ABS, AL, and C but not to GF, because of its solid nature. RESULTS: Median durations required for hemostasis in ABS, AL, GF, and C groups were recorded as 30, 90, 90, and 210 seconds, respectively. The time until termination of bleeding in the ABS group was significantly shorter than that in the AL, GF, and C groups (P = 0.002, P = 0.002, and P = 0.001, respectively). On histopathologic evaluation, after staining with HE, minimal fibrin at the incision edges and a few extravasated erythrocytes were observed in the C, AL, and GF groups. In the ABS group, a dark amorphous material surrounded by fibrin, filling the space between the edges of incisions, was noticed. Fibrin was determined in the C, GF, and AL groups with PTAH stain and in the positive control group. In the ABS group, it was observed that the amorphous substance surrounded by fibrin seen in the HE sections was not stained with PTAH. CONCLUSIONS: Topical nasal ABS application controlled epistaxis faster than C, GF, and AL in this animal bleeding model. The bleeding model used here might fail to replicate the type of injury that would be likely to result in life-threatening bleeding in humans, which should be considered a limitation of the present study. The histopathologic findings in the nasal incision area suggest that ABS might affect global hemostasis by inducing a unique protein network formation, potentially representing a different mechanism of action among conventional antihemorrhagic applications. (Curr Ther Res Clin Exp. 2011;72:185-194) (C) 2011 Elsevier HS Journals, Inc. All rights reserved.Öğe Are long-term auditory results following ossiculoplasty with bone cement as successful as early-middle period results?(W B Saunders Co-Elsevier Inc, 2020) Kalcioglu, M. Tayyar; Yalcin, Muhammed Zeki; Kilic, Osman; Tuysuz, Ozan; Tan, Mehmet; Ozdamar, Osman IlkayPurpose: Bone-cement (BC) ossiculoplasty is one of the options to solve ossicular chain problems. Many authors reported successful results in the early or mid-follow-up period; however, there is no long-term result in the literature. We aim to evaluate long term results of BC ossiculoplasty. Materials and methods: Forty-eight patients who underwent BC ossiculoplasty as incudostapedial re-bridging by the same surgeon were invited to evaluation. Postoperative otomicroscopic examination was performed. Preoperative and post-operative audiological results after longer follow up and graft success rate were noted. Results: Fourteen patients came for control examination. The follow-up period was between 87 and 135 months (mean 102 months). None of the patients had graft failure. Ten patients had early postoperative follow-up results (between 10 and 52; mean 24 months). In the comparison of preoperative and early postoperative air-bone gap, there were significant differences in all frequencies while the comparison of preoperative and long-term postoperative results showed a significant difference only in 250 and 500 Hz. Early postoperative results were better than late with significant difference only in the 2000 and 4000 Hz. Conclusions: As reported by many studies, bone cement application provides a significant auditory improvement in the early postoperative period. The results of the present study showed that this early auditory success may decrease over time with a long-term follow-up. Further studies should be conducted with larger patient groups to clarify the long-term benefits of this treatment and possible causes for its deterioration.Öğe Assessment of mucosal changes associated with nasal splint in a rabbit model(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2015) Tan, Mehmet; Kalcioglu, M. Tayyar; Sahin, Nurhan; Bayindir, Tuba; Samdanci, Emine; Filiz, AliyeIntroduction: There is no consensus on duration of the nasal splint after nasal septum surgeries. The pressure of nasal splint on the mucosa may cause tissue necrosis and nasal septum perforation. Objectives: To investigate the histopathological changes of the nasal mucosa caused by nasal splints in a rabbit model. Methods: No splint was used in group A. Bilateral silicone nasal splints were placed for five, ten, and 15 days in groups B, C, and D, respectively. Biopsy of the nasal mucosa was performed after removal of splint. Histopathologic evaluations were performed. The severity and depth of the inflammation were scored. Results: Group A had a normal histological appearance. Comparison of the results of groups B, C, and D with group A demonstrated statistically significant differences with regards to the severity of histopathological findings. There was no statistically significant difference between groups B and C. There were statistically significant differences between the groups B and D, and also between groups C and D. Conclusions: Longer duration of nasal splint had a higher risk for septal perforation. Therefore, removal of the splint as soon as possible may be helpful for preventing potential perforations. (C) 2015 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda. All rights reserved.Öğe Cartilage Tympanoplasty with Island Technique: A Comparison with the Temporalis Muscle Fascia Technique(Aves, 2009) Kalcioglu, M. Tayyar; Firat, Yezdan; Selimoglu, ErolObjective; To evaluate hearing results and failures of tympanoplasty techniques with either island cartilage or temporalis muscle fascia. Materials & Methods; Retrospective evaluation of selected cases operated by the same surgery team between 2000 and 2008. A total of 307 patients with a tympanic membrane perforation or retraction due to chronic otitis media were treated surgically with tympanoplasty with or without mastoidectomy. From these 96 cases who had primary repair of tympanic membrane perforation or retraction with intact ossicular chain and normal middle ear were included into the study. Tympanic membrane perforation was reconstructed by using fascia in 36 while cartilage island graft was used in 60 patients. Temporalis muscle fascia was preferred for simple perforations while cartilage was used in more difficult cases such as retractions or total or subtotal perforations. Preoperative and postoperative pure-tone average air-bone gaps were compared at 250, 500, 1000, 2000 and 4000 Hz frequencies. Postoperative failures were compared. Results; Main outcomes of both techniques were similar for hearing results and prevalence of failures. Closure of air-bone gaps after surgery were 14.98, 12.5, 9.67, 8.67, and 7.01 dB for cartilage group and 15.42, 11.67, 8.34, 7.36, and 8.61 dB for fascia group respectively. The differences were not statistically significant. Graft survival rates were 86.1% in the fascia group and 95% in the cartilage group. Conclusion; Both techniques show similar functional and hearing results. Cartilage tympanoplasty with island technique may be chosen according to patient's condition like atelectatic ear, adhesive otitis and retraction pockets, totally or sub totally perforation of tympanic membrane or revision tympanoplasty.Öğe The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin(Korean Soc Otorhinolaryngol, 2016) Toplu, Yuksel; Sapmaz, Emrah; Parlakpinar, Hakan; Kelles, Mehmet; Kalcioglu, M. Tayyar; Tanbek, Kevser; Kizilay, AhmetObjectives. This study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. Methods. To examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. Results. In the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P <0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group's measurements. Conclusion. According to these results, Dxp may prevent cisplatin-induced ototoxicity.Öğe Effectiveness of MESNA on the success of cholesteatoma surgery(W B Saunders Co-Elsevier Inc, 2014) Kalcioglu, M. Tayyar; Cicek, Mehmet T.; Bayindir, Tuba; Ozdamar, Osman IlkayImportance: It is important that chronic otitis media with cholesteatoma be treated successfully in patients to protect them from having repeated surgeries with related surgical co-morbidities and hearing loss. Objective: To evaluate the effectiveness of MESNA usage on the residual cholesteatoma rates of the patients who underwent surgery due to chronic otitis media with cholesteatoma. Design: Retrospective single-institution study of a prospectively collected database. Setting: Tertiary University Hospital. Participants: Nine hundred and thirty-four patients underwent surgery due to chronic otitis media between September 2000 and March 2012 by the same surgeon. One hundred and forty-one cases out of 934 patients were selected who had cholesteatoma for the study. These randomly selected 141 cases were divided into two groups as follows: I. Forty-six cases were applied MESNA (Sodium 2-mercaptoethanesulfonate) intraoperatively, and II. Ninety-five cases were not applied MESNA intraoperatively. The cases that were followed-up at least one year were included in this study. Intervention: MESNA (Ureomitexan, MESNA, Baxter oncology, Germany) was diluted with saline (20% MESNA and 80% saline) that was applied, and then a waiting period of approximately 5 min followed to start to dissect cholesteatoma matrix. Main outcomes and measures: Residual cholesteatoma rates between intraoperative MESNA, a disulfide bond breaking chemical agent, applied and MESNA non-applied cases in the postoperative follow-up period were compared for the success of the surgery. Results: MESNA was used in 46 patients out of 141 cases intraoperatively. Twenty-four of these patients underwent CWD (canal wall down), and twenty-two patients underwent CWU (canal wall up) mastoidectomy. For the other 95 subjects, 56 patients with CW.D and 39 with CWU mastoidectomy, MESNA was not applied. Residual cholesteatoma rates were found to be significantly higher in MESNA non-applied group than MESNA applied group (p <0.05). Residual cholesteatoma rates between CWD and CWU mastoidectomy procedures were not statistically significant (p > 0.05). Conclusions and relevance: MESNA application that breaks disulfide bonds in the structure of the matrix in cholesteatoma surgery may assist the elimination of the disease, and increase surgical success by facilitating the elevation of the epithelium. Thereby, it causes a decrease in the possibility of remaining residual epithelium after surgery, which decreases the need for second-look surgery. (C) 2014 Elsevier Inc. All rights reserved.Öğe The Effects of a New Hemostatic Agent on Hearing in Rats(Aves, 2010) Kalcioglu, M. Tayyar; Bayindir, Tuba; Iraz, Mustafa; Kaya, Serdar; Can, SermetObjective: Ankaferd Blood Stopper (ABS), a standardized mixture of five plants, has been used as a hemostatic agent. Studies have shown the hemostatic effectivity of this agent that suggests a potential usage in otological surgeries. However,side effects on hearing of this agent are unknown. In this study, hearing affection of local and systemic usage of ABS was investigated by using distortion product otoacoustic emissions (DPOAEs). Materials and Methods: Thirty-two male Wistar rats were used. The animals were divided into four groups. Baseline DPOAE measurements were performed. Subsequently, intratympanic ABS administration to the firstgroup and intratympanic saline administration to the second group were performed. Intraperitoneal ABS was injected to the third group. The fourth group was not administered any intervention. Side effects of ABS on hearing were evaluated by repeated DPOAE measurements carried out before and at 1st, 7th, and 40th days following the applications. Results: On days 7 and 40; measurement parameters of DPgrams of intratympanic ABS group were found to have significantly deteriorated in some frequencies (p(0.05). The measurements of the other groups revealed no significant differences (p>0.05). Hearing loss was not observed in systemic absorption group but, determined in intratympanic application group. Conclusion: Our findings may suggest that hearing loss may be either due to ototoxic side effect of ABS, prolonged mass effect of it, or because of inflammation. Further studies with longer follow up period and histopathological examinations are needed to answer these existing questions.Öğe Evaluation on Shear Bond Strength of Different Glass Ionomer and Hydroxy Apatite Cements Used in Ossiculoplasty(AVES,, 2015-01) Kalcioglu, M. Tayyar; Uzun, Ismail Hakki; Yalcin, Muhammet; Malkoc, Meral Arslan; Öğreten, Ayse Tuba; Hanege, Fatih MehmetBackground: Glass ionomer cements (GIC) have been widely used in dentistry for many years. In recent years, GIC have also been used for ossiculoplasty. The bond strength of GIC used in ossiculoplasty and the way they may change over the years in the cementation area are being questioned. The bonding strength of the substance may be of importance for long-term outcomes. Aims: The aim of this study was to investigate the bond strength of different GIC on ossicles. Study Design: In vitro study. Methods: Twenty ossicles were obtained from patients who had undergone ear surgery. All specimens were randomly divided into four subgroups. All specimens were inserted into a specially designed apparatus for shear bond strength (SBS) testing. The tested materials [Aqua Meron (AM), Aqua Cem (AC), Ketac Cem (KC), and Otomimix CPB (OH)] were prepared and applied according to the manufacturer's instructions. The SBS was tested using a universal testing machine at a crosshead speed of 0.5 mm/min. Results: The mean SBSs were found to be 13.28 MPa, 23.43 MPa, 8.51MPa, and 1.78 MPa for AM, AC, KC, and OH, respectively. AC had the highest SBS, which was statistically significantly different from that of KC and OH (p<0.05). Both AM and KC had higher SBS than OH (p<0.05). Conclusion: The results obtained in this study by investigating the bone-bonding strength of cements widely used in ossiculoplasty demonstrate that some of these substances have a greater ability to bond to ossicles compared to others. Further clinical investigations are needed to test different parameters.Öğe The Protective Effect of Chrysin Against Cisplatin Induced Ototoxicity in Rats(Springer India, 2014) Kelles, Mehmet; Tan, Mehmet; Kalcioglu, M. Tayyar; Toplu, Yuksel; Bulam, NazireOtotoxicity is a common side effect of cisplatin chemotherapy. The aim of this study was to investigate the potential protective effect of chrysin against cisplatin-induced ototoxicity. Thirty-four adult female Wistar albino rats were separated into four groups: a cisplatin group (Group A), with cisplatin administered to ten rats once daily for three consecutive days at doses of 8 mg/kg body weight intraperitoneally (i.p.); a cisplatin plus chrysin group (Group B), with 8 mg/kg of cisplatin administered i.p. daily to ten rats for three consecutive days and 25 mg/kg of chrysin administered via oral gavage in a corn oil for 5 days: a chrysin group (Group C), with 25 mg/kg of chrysin administered via oral gavage in corn oil for 5 days to seven rats; and a control group (Group D), with 5 ml/kg of corn oil administered to seven rats via oral gavage for 5 days. Distortion product otoacoustic emission measurements were performed in the same ear of the rats under general anesthesia at baseline and on the first and fifth days after drug administration. No significant differences were noted between the measurements either in the chrysin group or in the control group. In the cisplatin group, there was a significant worsening of hearing compared to baseline and the measurements on the fifth day at all frequencies. In the statistical analysis, a statistically significant difference was observed at 5039, 6351, 8003, and 10078 Hz frequencies between the measurements on the first and fifth days. In the cisplatin plus chrysin group, there were statistically significant differences at frequencies of 2,003 and 5,039 Hz between the measurements at baseline and on the fifth day, at 3,175 and 5,039 Hz between the measurements on the first and fifth days, and at 8,003 and 100,078 Hz between the measurements at baseline and on the first day. According to these results, this study demonstrates that cisplatin-related ototoxicity can be prevented in rats by the administration of chrysin.Öğe Schwannoma with an Uncommon Upper Lip Location and Literature Review(Hindawi Ltd, 2013) Bayindir, Tuba; Kalcioglu, M. Tayyar; Cicek, Mehmet T.; Karadag, Nese; Karaman, AbdurrahmanSchwannomas are usually single, encapsulated, and benign tumors of the nerve sheath that arise from the perineural Schwann cells. Schwannomas are mostly seen in the fourth decade. Despite its location in the head and neck region is 25-45%, lip location of schwannoma are very rare. We present a case of a upper lip schwannoma in the pediatric age and review the literature.Öğe Unusual case of soft plate hairy polyp causing airway obstruction and review of the literature(W B Saunders Co-Elsevier Inc, 2010) Kalcioglu, M. Tayyar; Can, Sermet; Aydin, Nasuhi EnginHairy polyps are rare benign tumors that are derived from 2 germ layers: ectoderm and mesoderm. Although location in the head and neck area is rare, the soft palate as the site of origin is even more unusual. The clinical presentation depends on the polyp's location and size. These masses can commonly cause respiratory and feeding difficulties. We present a case of a soft palate hairy polyp causing respiratory and feeding difficulties in a 6-month-old female infant and review the literature. (C) 2010 Elsevier Inc. All rights reserved.Öğe The use of bone cement for ossicular chain defects(Springer, 2013) Kalcioglu, M. Tayyar; Tan, Mehmet; Fleerakkers, JelleBone cement is a good and cheap option for some ossicular chain problems such as incudostapedial re-bridging. The purpose of this retrospective study is to evaluate the audiologic results after reconstruction of three different types of ossicular chain defects, using bone cement. Group 1 consists of 42 patients who underwent an ossiculoplasty using bone cement between the damaged long process of the incus and an intact stapes superstructure. Group 2 consists of 46 patients in which incus interposition between malleus and stapes superstructure was performed, using bone cement to fix the interposed incus. For group 3, consisting of 32 patients who had a present malleus, a defective long process of the incus and a missing stapes superstructure, a re-shaped incus was placed between the stapes footplate and the malleus and bone cement was again used as a fixator. Preoperative and postoperative pure-tone audiometric findings were obtained and hearing differences were assessed. The mean preoperative and postoperative air-bone gaps were 34.8 and 15.6, 35 and 18.4, and 43.4 and 19.8 for groups 1, 2, and 3, respectively. There was a significant improvement in hearing outcomes in all the groups when comparing preoperative and postoperative mean air-bone gaps (p < 0.001). The postoperative air-bone gap was a parts per thousand currency sign20 dB in 76 % of patients in group 1, 64 % of patients in group 2, and 46 % of patients in group 3. Bone cement is an effective and cheap option for some ossicular chain problems such as incudostapedial re-bridging. It may also be used to fix the interposed incus to the stapes superstructure and/or malleus to avert displacement.Öğe Üst Solunum Yolu Infeksiyonlarinda Moraxella catarrhalis’in Önemi(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2002) Özerol, Ibrahim Halil; Asgin, Nergis; Kalcioglu, M. TayyarM. catarrhalis, otitis media ve sinüzit gibi üst solunum yollari enfeksiyonlarinda etken olabilen bir patojendir. Bu çalismada üst solunum yolu enfeksiyonu ön tanisi almis 73 eriskin ve 31 çocuk olmak üzere toplam 104 hastanin nazofarinks ve bogaz sürüntü örneklerinde M. catarrhalis arastirildi. Yüz dört nazofarinks örneginin 35’inde (%33.6) ve bogaz sürüntü örneklerinin 20’sinde (%19.2) M. catarrhalis saptandi. Eriskinler için bu degerler sirasiyla 18 (%24.7) ve 13 (%17.8), çocuklar için 17 (%54.8) ve 7 (%22.6) olarak bulundu. Bu sonuçlar, ÜSYE etiyolojisinde M. catarrhalis’in önemli oranda rol oynadigini desteklemektedir.