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    The effect of the addition of clonidine to lidocaine during regional intravenous anaesthesia
    (2003) Durmuş M.; Tüköz A.; Gülhaş N.; Karaaslan E.; Ersoy M.Ö.
    Intravenous regional anaesthesia (IVRA), is a simple and convenient anaesthetic method that can be used in extremity surgeries for surgical analgesia. But absence of postoperative analgesic effect is an important disadvantage of this method. In this study, we aimed to evaluate the addition of clonidine to lidocaine on quality of peroperative analgesia in IVRA. After obtaining the Ethics Commitee approval, ASA I-II class, 40 patients undergoing elective surgery included to the study. Following Esmarch bandage and inflating of proximal tourniquet 100 mmHg over the systolic arterial pressure, cases divided into lidocaine 4 mg kg-1 (Group A, n=20) and lidocaine 4 mg kg-1 + clonidine 0.5 ?g kg-1 (Group B, n=20) groups. Ten minutes after the injection, proximal tourniquet deflated and distal tourniquet inflated. Preoperative basal measurements and heart rate and blood pressures were recorded 5 times with 2 minutes intervals after tourniquet deflation. VAS scores and sedation scores were evaluated in the first and second hours. Patient's first analgesic taking time was recorded. No significant statistical differences were detected in level of analgesia during operation between groups. Mean heart rate did not changed between groups after tourniquet deflation. Blood pressure values in group B, both within group and between groups were lower (p<0.05). VAS averages were lower in first and second hours in group B (p<0.05). In group B, the first analgesic taking time was longer than group A (p<0.05). We concluded that during IVRA, adding clonidine to lidocaine increases the analgesia quality after tourniquet deflation and prolongs the first analgesic need of cases.
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    Preemptive effectiveness of celecoxib in patients undergoing total abdominal hysterectomy
    (2003) Karaaslan E.; Durmuş M.; Demirbilek S.; Köro?lu A.; To?al T.; Karaaslan K.; Ersoy M.O.
    We aimed to investigate the effects of preemptive oral 100 mg and 200 mg celecoxib in relief of postoperative pain and morphine consumption after total abdominal hysterectomy. Fifty-four, ASA I-II class adult cases were enrolled in this study. One hour before the operation, celecoxib was administered per oral 100 and 200 mg to group I and II respectively and group III served as a control. All patients received IV PCA with morphine. PCA was programmed as follows: 2 mg loading dose, 1 mg bolus dose and 10 minutes lock-out time for a 20 mg limitation for four hours. All patients underwent a standardized general anaesthetic induction and maintenance. During the operation no analgesic medication was used. After operation, pain scores (VAS at rest, on movement and on coughing) were evaluated at 2, 4, 8, 12, 24, 48 and 72. hours. The morphine consumption was recorded at 2, 4, 8, 12 and 24. hours post-operatively. Sedation scores and peripheral oxygen saturation were recorded at 1, 2, 4, 8, 12, 16 and 24. hours post-operatively. The total morphine consumption was 24.78±5.95, 24.44±9.18 and 34.78±10.38 in group I, II and III. That consumption in group 3 was significantly higher than group I and II. VAS at rest, movement and coughing were significantly higher in group III. We concluded that preemptive oral celecoxib 100 mg may be used as an additive to IV PCA with morphine for post-operative analgesia after abdominal hysterectomy.