Preemptive effectiveness of celecoxib in patients undergoing total abdominal hysterectomy
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We aimed to investigate the effects of preemptive oral 100 mg and 200 mg celecoxib in relief of postoperative pain and morphine consumption after total abdominal hysterectomy. Fifty-four, ASA I-II class adult cases were enrolled in this study. One hour before the operation, celecoxib was administered per oral 100 and 200 mg to group I and II respectively and group III served as a control. All patients received IV PCA with morphine. PCA was programmed as follows: 2 mg loading dose, 1 mg bolus dose and 10 minutes lock-out time for a 20 mg limitation for four hours. All patients underwent a standardized general anaesthetic induction and maintenance. During the operation no analgesic medication was used. After operation, pain scores (VAS at rest, on movement and on coughing) were evaluated at 2, 4, 8, 12, 24, 48 and 72. hours. The morphine consumption was recorded at 2, 4, 8, 12 and 24. hours post-operatively. Sedation scores and peripheral oxygen saturation were recorded at 1, 2, 4, 8, 12, 16 and 24. hours post-operatively. The total morphine consumption was 24.78±5.95, 24.44±9.18 and 34.78±10.38 in group I, II and III. That consumption in group 3 was significantly higher than group I and II. VAS at rest, movement and coughing were significantly higher in group III. We concluded that preemptive oral celecoxib 100 mg may be used as an additive to IV PCA with morphine for post-operative analgesia after abdominal hysterectomy.
Açıklama
Anahtar Kelimeler
Celecoxib, Patient controlled analgesia (PCA), Preemptive analgesia
Kaynak
Turk Anesteziyoloji ve Reanimasyon
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
31
Sayı
2
