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    A2BO4±? as New Materials for Electrocatalytic Detection of Paracetamol and Diclofenac Drugs
    (Springer, 2022) Zine, Amel; Ferkhi, Mosbah; Khaled, Ammar; Savan, Ebru Kuyumcu
    In this study, the electrochemical detection of drugs in the human body such as paracetamol and diclofenac was performed using the La2NiO4/carbon black and Pr2NiO4/carbon black electrocatalysts as sensor. The oxide materials were synthesized by the citrate method. The crystallinity of materials was determined by X-ray diffraction; the cell parameters and the crystallite size were calculated using the Debye-Scherrer formula. Morphology and grain size were determined by scanning electron microscope and the pore size was determined by the BET analysis. X-ray photoelectron spectroscopy analysis was used to evaluate the surface state of the synthesized oxide powders. Electrochemical characterization of the drugs on the electrocatalysts was carried out by cyclic voltammetry at different scanning speeds in a range of drug concentrations between 3 and 200 mu mol in a phosphate-buffered saline solution at pH 7. The square wave method was used to determine the detection limits. The synthesized nano-particle-based electrodes demonstrated excellent sensitivity in detecting drug/biomolecules (PCM and DIC) in biological fluids with the minimum detection limit 1.99 mu M and 2.32 mu M, respectively, at La2NiO4/carbon black electrode and 2.04 mu M and 2.37 mu M, respectively, at Pr2NiO4/carbon black electrode. The peak currents relative to the detection of the paracetamol and diclofenac drugs are respectively 800 and 1000 on La2NiO4/carbon black and 1000 and 500 mu A on Pr2NiO4/carbon black. This remarkable behavior enables us to propose these materials as alternative electrocatalysts that act as selective sensors for drug detection in the human body.
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    Electrochemical Bio-Monitoring of the Analgesic Drug Paracetamol, the Antipsychotic Sulpiride, and the Antibiotic Bromhexine Hydrochloride Using Modified Carbon Paste Electrode Based on Ca 0.7 La 0.3 Fe 0.3 Ni 0.7 O 3 Nano-Sized Particles and Black Carbon
    (Elsevier, 2024) Mekersi, Mouna; Ferkhi, Mosbah; Khaled, Ammar; Maouche, Naima; Foudia, Malika; Savan, Ebru Kuyumcu
    Drug biomonitoring using developed modified sensors, especially with recent electrochemical techniques, is considered an essential step and plays a significant role in the good detection of several drugs in biofluids, minimizing the damages resulting from their overdoses. This work is based on the detection of three important drugs such as paracetamol (PCM), sulpiride (Sulp), and bromhexine hydrochloride (Brh-HCl) with different pharmaceutical families. A specific sensor was fabricated called the carbon paste electrode (CPE) based on Ca 0.7 La 0.3 Fe 0.3 Ni 0.7 O 3 (CLFN) nanoparticles (NPs) synthesized by a citrate method and modified with black carbon (BC). A low-cost, highly sensitive BC/CLFN NPs/CPE sensor was prepared for the simultaneous determination of the three drugs using cyclic voltammetry (CV), differential pulse voltammetry (DPV), square wave voltammetry (SWV) and electrochemical impedance spectroscopy (EIS). Physicochemical characterization was conducted using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The calculated crystallite size using the Debye-Scherer equation was 237.08 nm by XRD, while the nanoparticles grain size was 60.27 nm extracted from SEM surface images. As a result, the developed sensor demonstrates a high response and sensitivity towards PCM, Sulp, and Brh-HCl molecules compared to literature with excellent and low detection limits of 0.36 mu M, 0.042 mu M, and 2.88 mu M for PCM, 0.073 mu M, 0.12 mu M, 15.45 mu M for Sulp, and 0.407 mu M, 0.17 mu M, 7.82 mu M for Brh-HCl drug by CV, DPV and SWV techniques, respectively. High sensitivities of 6588.07, 149.73, and 83.35 mu A. mu M- 1 .cm- 2 for PCM, Sulp, and Brh by CV technique, respectively with wide linear range from 0.01 mu M to 180 mu M for PCM, from 0.1 mu M to 160 mu M for Sulp, and from 0.5 mu M to 240 mu M for Brh by DPV technique. Additionally, the modified CLFN NPs/BC/CPE sensor demonstrated excellent results in real pharmaceutical samples for all three drugs. The reported results include very good recoveries of 104.21 %, 98.68 %, and 95.50 %, and excellent relative standard deviations of 1.18 %, 1.52 %, and 2.84 %, respectively.