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(3R, 3'R)-zeaxanthin protects the retina from photo-oxidative damage via modulating the inflammation and visual health molecular markers
(Taylor & Francis Ltd, 2019) Sahin, Kazim; Akdemir, Fatih; Orhan, Cemal; Tuzcu, Mehmet; Gencoglu, Hasan; Sahin, Nurhan; Ozercan, Ibrahim H.
Purpose: Zeaxanthin protects the macula from ocular damage due to light or radiation by scavenging harmful reactive oxygen species. In the present study, zeaxanthin product (OmniXan (R); OMX), derived from paprika pods (Capsicum annum; Family-Solanaceae), was tested for its efficacy in the rat retina against photooxidation. Methods: Forty-two male 8-week-old Wistar rats exposed to 12L/12D, 16L/8D and 24L/0D hours of intense light conditions were orally administrated either 0 or 100 mg/kg BW of zeaxanthin concentration. Retinal morphology was analyzed by histopathology, and target gene expressions were detected with real-time polymerase chain reaction methods. Results: OMX treatment significantly increased the serum zeaxanthin concentration (p < 0.001) and ameliorated oxidative damage by increasing the antioxidant enzyme activities in the retina induced by light (p < 0.001). OMX administration significantly upregulated the expression of genes, including Rhodopsin (Rho), Rod arrestin (SAG), G alpha Transducin 1 (GNAT-1), neural cell adhesion molecule (NCAM), growth-associated protein 43 (GAP43), nuclear factor-(erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase (HO-1) and decreased the expression of nuclear factor-kappa B (NF- kappa B) and GFAP by OMX treatment rats. The histologic findings confirmed the antioxidant and gene expression data. Conclusions: This study suggests that OMX is a potent substance that can be used to protect photoreceptor cell degeneration in the retina exposed to intense light.
3R, 3?R zeaxanthin Protects Retina from Photo-Oxidative Damage: in vivo model
(Wiley, 2017) Sahin, Nurhan; Akdemir, Fatih; Orhan, Cemal; Tuzcu, Mehmet; Yilmaz, Ismet; Juturu, Vijaya
[Abstract Not Available]
Acute Abdominal Pain With Rupture Of Uterine Leimyosarcoma
(Lippincott Williams & Wilkins, 2016) Coskun, Ebru Inci; Yilmaz, Ercan; Sahin, Nurhan
[Abstract Not Available]
Assessment of mucosal changes associated with nasal splint in a rabbit model
(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2015) Tan, Mehmet; Kalcioglu, M. Tayyar; Sahin, Nurhan; Bayindir, Tuba; Samdanci, Emine; Filiz, Aliye
Introduction: There is no consensus on duration of the nasal splint after nasal septum surgeries. The pressure of nasal splint on the mucosa may cause tissue necrosis and nasal septum perforation. Objectives: To investigate the histopathological changes of the nasal mucosa caused by nasal splints in a rabbit model. Methods: No splint was used in group A. Bilateral silicone nasal splints were placed for five, ten, and 15 days in groups B, C, and D, respectively. Biopsy of the nasal mucosa was performed after removal of splint. Histopathologic evaluations were performed. The severity and depth of the inflammation were scored. Results: Group A had a normal histological appearance. Comparison of the results of groups B, C, and D with group A demonstrated statistically significant differences with regards to the severity of histopathological findings. There was no statistically significant difference between groups B and C. There were statistically significant differences between the groups B and D, and also between groups C and D. Conclusions: Longer duration of nasal splint had a higher risk for septal perforation. Therefore, removal of the splint as soon as possible may be helpful for preventing potential perforations. (C) 2015 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda. All rights reserved.
Beneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat model
(Taylor & Francis Ltd, 2016) Cagin, Yasir Furkan; Atayan, Yahya; Sahin, Nurhan; Parlakpinar, Hakan; Polat, Alaadin; Vardi, Nigar; Tagluk, Mehmet Emin
Background and aim It has been reported that intestinal ischemia-reperfusion (I/R) injury results from oxidative stress caused by increased reactive oxygen species. Dexpanthenol (Dxp) is an alcohol analogue with epitelization, anti-inflammatory, antioxidant, and increasing peristalsis activities. In the present study, the aim was to investigate protective and therapeutic effects of Dxp against intestinal I/R injury. Materials and methods Overall, 40 rats were assigned into five groups including one control, one alone Dxp, and three I/R groups (40-min ischemia; followed by 2-h reperfusion). In two I/R groups, Dxp (500mg/kg, i.m.) was given before or during ischemia. The histopathological findings including apoptotic changes, and also tissue and serum biochemical parameters levels, were determined. Oxidative stress and ileum damage were assessed by biochemical and histological examination. In the control (n=8) and alone Dxp (n=8; 500mg/kg, i.m. of Dxp was given at least 30min before recording), groups were incised via laparotomy, and electrical activity was recorded from their intestines. In this experiment, the effect of Dxp on the motility of the intestine was examined by analyzing electrical activity. Results In ileum, oxidant levels were found to be higher, while antioxidant levels were found to be lower in I/R groups when compared with controls. Dxp approximated high levels of oxidants than those in the control group, while it increased antioxidant values compared with I/R groups. Histopathological changes caused by intestinal I/R injury and histological improvements were observed in both groups given Dxp. In the Dxp group, electrical signal activity markedly increased compared with the control group. Conclusions Here, it was seen that Dxp had protective and therapeutic effects on intestinal I/R injury and gastrointestinal system peristaltism.
Carbontetrachloride induced acute liver damage and protective effect of n-acetylcysteine on rats with regenerated and non-regenerated liver
(Walter De Gruyter Gmbh, 2016) Bilgic, Sedat; Ozerol, Elif; Iraz, Mustafa; Sahin, Nurhan; Tanbek, Kevser; Cigli, Ahmet
Objective: Our aim was to investigate 70% partial hepatectomy (PH) groups, compare with not subjected to PH groups after exposure to hepatotoxic agents for alterations in the protective effects of antioxidant agents and sensitivity of the liver. Accordingly, we aimed to investigate the toxicity of a hepatotoxic agent, carbon tetrachloride (CCl4), and protective effects of an antioxidant, N-acetylcysteine (NAC), in experimental animal model. Methods: 67 male Wistar Albino rats were divided into 2 main groups to total 9 subgroups: group 1, underwent PH; group 2, not subjected to PH. 0.5 ml/kg CCl4 and 50 mg/kg NAC was given intraperitoneally (i.p.) to the groups. On postoperative day 9, 70% PH was performed according to the method of Higgins and Anderson. Finally, all rats were humanely killed. Results: Catalase (CAT) and superoxide dismutase (SOD) activities were significantly lower in both groups when CCl4 was administered. NAC treatment was found to significantly increase these parameters (P<0.05). Malondialdehyde (MDA) and protein carbonyl (PC) levels were significantly greater in both groups when CCl4 was administered (P<0.05). NAC treatment was found to significantly reduce these parameters. Conclusion: These results indicated that CCl4 increased oxidation products, reduced liver enzymatic activity and reduced proliferation activity in both hepatectomised and nonhepatectomised liver. The liver injury of CCl4 and the protective effect of NAC was similarly in both main groups. Consequently, making PH may not create a negative effect and an additional health problems in liver. Thus, these results can positively affect the decisions of the healthy liver donors.
A case of angioedema-like atypic scleromyxedema responding to treatment with steroid
(Deri Zuhrevi Hastaliklar Dernegi, 2016) Polat, Aysegul; Kapicioglu, Yelda; Sahin, Nurhan; Yilmaz, Mikail
Lichen myxedematosus is a chronic, inflammatory, systemic dermatose characterized by dermal musin deposition and increased fibroblasts in the absence of thyroid dysfunction. It is usually seen together with paraproteinemia. It is clinically classified as scleromyxedema (papular mucinosis), localized lichen myxedematosus, and atypical lichen myxedematosus. Etiopathogenesis of the disease which is very difficult to treat is still unknown. Herein, we present a case of atypical scleromyxedema without monoclonal gammopathy mimicking angioedema, rapidly developing and responding to steroid treatment.
Clinical and histopathological analysis of 1694 cases diagnosed with endometrial polyps based on endometrial sampling
(2019) Sahin, Nurhan; Coban, Ganime; Sezal, Zeynep; Kilic, Gokhan; Cali, Halime; Arici, Dilek Sema
Aim: All the patients presented to gynecology polyclinics with abnormal uterine bleeding either during the reproductive or the peri/ postmenopausal period underwent endometrial sampling to exclude endometrial pathologies. One endometrial pathology frequently encountered in the histopathological examination of these samples is Endometrial Polyp (EP); and it is important that they are recognized as they require a distinct treatment plan and can be associated with endometrial malignancies. Material and Methods: In this study, we investigated the demographic and clinical findings and concomitant malignancies of the cases diagnosed with endometrial polyps based on endometrial biopsy samples at Bezmialem Vakif University over a period of 7 years and compared our results with those in the literature. Results: Our study determined an EP prevalence of 19% and only 11 (0.65%) of the 1694 cases were found to have “adenocarcinomas” within/outside the polyp. Conclusion: Considering that EPs may be associated with malignancies, histopathological examination must absolutely be performed with adequate sampling.
Clinical and Pathological Findings on Intoxication by Yellow Phosphorus After Ingesting Firework Cracker: A Rare Case of Autopsy
(De gruyter poland sp zoo, bogumıla zuga 32a str., 01-811 warsaw, poland, 2016) Samdanci, Emine Turkmen; Cakir, Ebru; Sahin, Nurhan; Elmali, Candan; Sayin, Sadegul
Yellow phosphorus is a toxic substance used in the production of firework cracker, fireworks, ammunition and agricultural dung. When ingested, it shows its effects mainly in the liver, the kidneys, and the brain. A four-year-old girl had died as a result of acute hepatic failure caused by ingesting a firework cracker. The case showed high levels of hepatic enzymes, along with non-specific signs such as nausea, vomiting and diarrhea. Autopsy revealed diffuse microvesicular steatosis in the liver and disseminated degeneration in the proximal tubules of the kidneys. In cases with concomitant hepatorenal failure and cardiovascular collapse, death is inevitable. However, when only hepatic failure develops, hepatic transplantation may be lifesaving. Although intoxication from ingesting yellow phosphorus has a very high rate of mortality, forensic cases are extremely rare in the literature.
Comparative evaluation of the sexual functions and NF-?B and Nrf2 pathways of some aphrodisiac herbal extracts in male rats
(Bmc, 2016) Sahin, Kazim; Orhan, Cemal; Akdemir, Fatih; Tuzcu, Mehmet; Gencoglu, Hasan; Sahin, Nurhan; Turk, Gaffari
Background: Mucuna pruriens, Tribulus terrestris and Ashwagandha (Withania somnifera) are widely known as antioxidant effective herbals and have been reported to possess aphrodisiac activities in traditional usages. In this study, we determined the effects of these herbals on sexual functions, serum biochemical parameters, oxidative stress and levels of NF-kappa B, Nrf2, and HO-1 in reproductive tissues. Methods: Thirty-five male rats were divided into five groups: the control group, sildenafil-treated group (5 mg/kg/d), Mucuna, Tribulus and Ashwagandha groups. The extract groups were treated orally either with Mucuna, Tribulus or Ashwagandha (300 mg/kg b.w.) for 8 weeks. Results: All of the extracts were found to be significantly effective in sexual functioning and antioxidant capacity and Tribulus showed the highest effectiveness. Serum testosterone levels significantly increased in Tribulus and Ashwagandha groups in comparison to control group. Tribulus was able to reduce the levels of NF-kappa B and increase the levels of Nrf2 and HO-1 to a much greater extent than Mucuna and Ashwagandha. Conclusions: These results demonstrate for the first time that Mucuna, Tribulus and Ashwagandha supplementation improves sexual function in male rats via activating Nrf(2)/HO-1 pathway while inhibiting the NF-kappa B levels. Moreover, Tribulus terrestris extract was found to be more bioavailable from Ashwagandha extract followed by Mucuna extract.
?-Cryptoxanthin ameliorates metabolic risk factors by regulating NF-?B and Nrf2 pathways in insulin resistance induced by high-fat diet in rodents
(Pergamon-Elsevier Science Ltd, 2017) Sahin, Kazim; Orhan, Cemal; Akdemir, Fatih; Tuzcu, Mehmet; Sahin, Nurhan; Yilmaz, Ismet; Juturu, Vijaya
The aim of this experiment was to determine the effects of beta-cryptoxanthin (BCX) on the cardiometabolic health risk factors and NF-kappa B and Nrf2 pathway in insulin resistance induced by high-fat diet (HFD) in rodents. Twenty-eight Sprague-Dawley rats were allocated into four groups: (1) Control, rats fed a standard diet for 12 weeks; (2) BCX, rats fed a standard diet and supplemented with BCX (2.5 mg/kg BW) for 12 weeks; (3) HFD, rats fed a HFD for 12 weeks, (4) HFD + BCX, rats fed a HFD and supplemented with BCX for 12 weeks. BCX reduced cardio-metabolic health markers and decreased inflammatory markers (P < 0.001). Rats fed a HFD had the lower total antioxidant capacity and antioxidant enzymes activities and higher MDA concentration than control rats (P < 0.001 for all). Comparing with the HFD group, BCX in combination with HFD inhibited liver NF-kappa B and TNF-alpha expression by 22% and 14% and enhanced liver Nrf2, HO-1, PPAR-alpha, and p-IRS-1 by 1.43,1.41, 3.53, and 1.33 fold, respectively (P < 0.001). Furthermore, in adipose tissue, BCX up-regulated Nrf2, HO-1, PPAR-alpha, and p-IRS-1 expression, whereas, down-regulated NF-kappa B and TNF-alpha expression. In conclusion, BCX decreased visceral fat and cardiometabolic health risk factors through modulating expressions of nuclear transcription factors. (C) 2017 Elsevier Ltd. All rights reserved.
Cytological and cytomorphometric characteristics of buccal mucosa cells from smokeless tobacco users
(Wiley, 2017) Dagli, Adile Ferda; Sahin, Nurhan; Bozdag, Zehra; Ucer, Ozlem; Akatli, Ayse Nur; Artas, Gokhan; Sahin, Ibrahim
BackgroundUse of smokeless tobacco (ST) is increasing in many communities. We investigated whether ST alters the cytological and cytomorphometric features of buccal mucosa cells. MethodsTwenty male participants who had used Nicotiana rustica Linn.-containing ST (Maras powder) for at least 10 years, and 20 healthy male controls who did not use ST, were included in this study. After rinsing the mouth with water, samples were taken using a toothbrush from the buccal mucosa of subjects in both groups. Samples were gently spread over a glass slide. After applying a cytofixative spray, the Papanicolaou method was used to stain the slides. The presence of dysplasia, dyskeratosis, parakeratosis, hyperkeratosis, hypergranulosis, karyorrhexis, and pyknosis was evaluated by light microscopy, as were the increment amount of candida, cocco-bacillus, and Leptotrichia buccalis. Cytomorphometric analysis was performed and at least 20 cells with well-defined borders were evaluated from each slide, and the cellular diameter (CD), nuclear diameter (ND), and nucleus/cytoplasm (N/C) ratio of the cells were analyzed using a 60x objective. ResultsOther than the presence of dysplasia and candida, all measured cytological parameters were significantly higher in the ST users than in the non-ST users. Furthermore, CD was lower while nuclear/cytoplasmic ratio was higher in the ST users than in those non-ST users. ConclusionCytological changes associated with the use of ST, include dyskeratosis, parakeratosis, hyperkeratosis, hypergranulosis, karyorrhexis, pyknosis together with increase in the bacterial population of cocco-bacillus and L. buccalis. There were no significant differences in patients with dysplasia in spite of reduction of CD, increased nuclear size and N/C ratio.
Dietary Mango Ginger May Enhance the Exercise Performance and Reduces Lipid Profile when Combined with Treadmill Running in a Rat Model
(Wiley, 2017) Sahin, Kazim; Tuzcu, Mehmet; Orhan, Cemal; Sahin, Nurhan; Akdemir, Fatih; Pala, Ragip; Juturu, Vijaya
[Abstract Not Available]
Effect of inositol -stabilized arginine silicate on arthritis in a rat model
(Pergamon-Elsevier Science Ltd, 2019) Sahin, Kazim; Ojalvo, Sara Perez; Akdemir, Fatih; Orhan, Cemal; Tuzcu, Mehmet; Sahin, Nurhan; Ozercan, Ibrahim H.
The purpose of this study was to test the effects of arginine-silicate-inositol complex (ASI), compared to a combination of the individual ingredients (A + S + I) of the AM, on inflammatory markers and joint health in a collagen-induced arthritis (CIA) rat model. A total of 28 Wistar rats were divided into four groups: (i) Control; (ii) Arthritic group, rats subjected to CIA induction by injection of bovine collagen type II (A); (iii) Arthritic group treated with equivalent doses of the separate components of the ASI complex (arginine hydrochloride, silicon, and inositol) (A + S + I); (iv) Arthritic group treated with the ASI complex. The ASI complex treatment showed improved inflammation scores and markers over the arthritic control and the A + S + I group. ASI group had also greater levels of serum and joint-tissue arginine and silicon than the A + S + I group. Joint tissue IL-6, NF-kappa B, COX-2, TNF-alpha, p38 MAPK, WISP-1, and beta-Catenin levels were lower in the ASI group compared to the other groups (P < 0.05 for all). In conclusion, these results demonstrate that the ASI complex may be effective in reducing markers of inflammation associated with joint health and that the AM complex is more effective than a combination of the individual ingredients.
The effect of lycopene on antioxidant status in rainbow trout (Oncorhynchus mykiss) reared under high stocking density
(Elsevier Science Bv, 2014) Sahin, Kazim; Yazlak, Hasan; Orhan, Cemal; Tuzcu, Mehmet; Akdemir, Fatih; Sahin, Nurhan
Lycopene, the major carotenoid found in tomato, exhibits health beneficial effects by virtue of its antioxidant activity. As stocking density is known as a stress factor in fish, the effects of dietary lycopene supplementation (0, 200 or 400 mg kg(-1)) on growth performance and antioxidant status in rainbow trout under normal (20 kg m(3-1)) and high (100 kg m(3-1)) stocking density were studied. Glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activities were evaluated, as well as lipid peroxidation measured as malondialdehyde (MDA). Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B), erythroid-derived 2-like 2 (Nrf2) and heme-oxygenase 1 (HO-1) levels were also assayed as an indicator of detoxifying/antioxidant defense mechanisms to cope with oxidative stress. Results showed that exposure to high stocking density depressed feed intake by 6.8% and body weight gain by 12.1%, increased plasma and hepatic MDA level by 88.5 and 124.3% and decreased hepatic SOD, CAT and GSH-Px activities by 22.1, 43.4 and 51.7%, respectively. In fish under crowded conditions, an expression of hepatic NF-kappa B was increased by 71.5%, being suppressed in Nrf2 and HO-1 by 40.6 and 42.7%, respectively. Lycopene supplementation increased linearly fish growth performance and antioxidant enzyme activity, and decreased linearly MDA concentration in both low and high stocking densities. NF-kappa B levels decreased hepatic Nrf2 and HO-1 levels increased linearly with lycopene supplementation at a greater extent in fish under low stocking condition. In conclusion, dietary supplementation of lycopene to fish reduces the detrimental effects of high stocking density on growth performance and modulates oxidative status via activating host defense system at cellular level. It appears that lycopene can be added up to 400 mg kg(-1) to rainbow trout diets to improve meat quality. (C) 2013 Elsevier B.V. All rights reserved.
Effect of microfracture and autologous-conditioned plasma application in the focal full-thickness chondral defect of the knee: an experimental study on rabbits
(Biomed Central Ltd, 2015) Karakaplan, Mustafa; Elmali, Nurzat; Mirel, Efe; Sahin, Nurhan; Ergen, Emre; Elmali, Candan
Purpose: The aim of the present study was to evaluate the effect of microfracture and intraarticular autologous conditioned plasma (ACP) injection on cartilage regeneration in a focal full-thickness chondral defect model created in the knee joint. Methods: Full-thickness chondral defects of 3 x 6 mm(2) were surgically created in right medial femoral condyles (MFC) of New Zealand rabbits, and the rabbits were then divided into three groups according to treatment: Group 1 received only microfracture (mfx), Group 2 received mfx plus intraarticular ACP, and Group 3 received mfx; the defect was covered by the periosteum, and then, ACP was applied subperiosteally and intraarticularly. Twelve weeks after injection, the animals were sacrificed and the femoral condyles were evaluated macroscopically and histologically by hematoxylin-eosin staining. Then, histological sections were scored using the International Cartilage Repair Society (ICRS) visual histological scale. Results: Findings showed that in both mfx/ACP-treated groups, the defects were filled regularly and smoothly, the defects had a greater fill and good integration into the surrounding host tissue, and the repair matrix had more hyaline-like character. On the other hand, defects were filled with an irregular, fibrous cartilage in the mfx-treated group. Histological scores in Group 2 and Group 3 were better compared to Group 1. Conclusion: In the present study, we were able to demonstrate a beneficial effect of intraarticular administration of ACP as a coadjuvant of microfractures in order to regenerate hyaline-like cartilage in full-thickness chondral lesions in a rabbit model.
The Effect of Selenium on Ischemia-Reperfusion Injury: An Experimental Study on a Transverse Rectus Abdominis Musculocutaneous Flap Model
(Lippincott Williams & Wilkins, 2016) Tenekeci, Goktekin; Bilen, Bilge Turk; Turkoz, Yusuf; Sahin, Nurhan; Bulam, Nazire; Erdemli, Mehmet Erman
Background:The aim of this study is to investigate effects of selenium and enlighten the possible mechanism of action in a rat transverse musculocutaneous flap model following ischemia-reperfusion injury.Materials and Methods:In this study, an experimental model, which mimicked free tissue transfer, was applied. Twenty-four male Wistar Albino rats were divided into a control group (N=12), and a selenium treated group (N=12). A superiorly based transverse rectus abdominis musculocutaneous (TRAM) flap was elevated and an ischemic insult for 4 hours was given. In selenium treated group (Group 2), sodium selenite (0.625mg/kg) was injected intraperitoneally (i.p), 2 hours before the induction of ischemia. Six rats from each group were sacrificed at 24 hours after the operation and malonyldialdehyde (MDA), nitric oxide (NO), and glutathione (GSH) levels were measured biochemically, whereas the intensity of neutrophil infiltration was evaluated. For the rest of the rats in Group 2, sodium selenite was injected at the same dose everyday to the postoperative 10th day, in which the remaining 6 rats from each group were sacrificed. On postoperative 10th day, flap viability was assessed along with the evaluation of intensity of neovascularization.Results:In Group 1, MDA levels were higher significantly (P<0.05) when compared with Group 2. No statistical difference, however, was found for NO (P>0.05), and GSH (P>0.05) levels among Group 1 and 2. Neutrophil infiltration was more intense in Group 1, when compared with Group 2 whereas neovascularization was more abundant in samples of Group 2. Group 2 shows higher average flap surface areas when compared with Group 1 (P<0.05).Discussion:The results of this study demonstrated the preventive effect of selenium against ischemia-reperfusion injury by reducing tissue necrosis in muscle flaps possibly by decreasing MDA, increasing neovascularization, and decreasing neutrophil infiltration, thus suppressing inflammation.
The efficacy of dietary curcumin on growth performance, lipid peroxidation and hepatic transcription factors in rainbow trout Oncorhynchus Mykiss (Walbaum) reared under different stocking densities
(Wiley, 2017) Akdemir, Fatih; Orhan, Cemal; Tuzcu, Mehmet; Sahin, Nurhan; Juturu, Vijaya; Sahin, Kazim
Curcumin, derived from Curcuma longa, exerts antioxidant, antibacterial, anticancer and immunomodulatory properties. This study was conducted to determine the effect of dietary water-soluble curcumin (0, 200 or 400mgkg(-1)) on growth performance and antioxidant status in rainbow trout (Oncorhynchus mykiss, Walbaum) rearing under normal (20kgm(-3)) or high (100kgm(-3)) stocking density conditions. A significant increase in body weight (FBW), feed intake (FI) and weight gain (BWG) was observed in fish fed with curcumin-supplemented diet at 200mgkg(-1) of diet levels of high stocking density conditions (P<0.0001), whereas feed conversion ratio (FCR) was not significant. Also, serum and liver malondialdehyde (MDA) levels were decreased by dietary curcumin in crowded fish (P<0.01, for both). With curcumin supplementation, expressions of heat shock protein 70 (HSP70; P<0.0001) and hepatic nuclear factor kappa-B (NF-B; P<0.01) decreased, whereas expressions of hepatic nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) (P<0.001, for both) increased in fish exposed to high stocking density. In conclusion, curcumin supplementation alleviates adverse effects of high stocking density on performance through modulating expressions of stress-related nuclear transcription factors in rainbow trout.
Fascioliasis: A Rare Parasitic Infection-Mimicking Tumor in the Liver: Report of Two Cases
(De Gruyter Poland Sp Zoo, 2019) Samdanci, Emine; Sahin, Nurhan; Dagli, Adile Ferda; Akatli, Ayse Nur; Aydin, Nasuhi Engin
Fascioliasis is a rarely encountered parasitic infection in Turkey that mainly affects the liver and bile ducts. Other defined localizations of the parasite are the lungs, gastrointestinal system, and subcutaneous fatty tissue. Two cases of female patients who presented to the hospital with abdominal pain and whose physical examination and laboratory findings were normal except peripheral eosinophilia, were detected to have liver masses with necrotic areas. Segmental hepatectomies were performed in both cases with the preliminary diagnosis of liver tumors. Upon microscopic examinations of the resection materials, necrotic granulomatous inflammation with eosinophilic reaction at the periphery and the parasite (Fasciola hepatica) were seen. Both cases were reported to be fascioliasis according to these findings. Two cases of fascioliasis mimicking malignancy in the liver are presented here together with literature findings.
Histopathological subtyping of actinic keratosis and it's coexistence with nonmelanotic skin cancers in Gaziantep and Malatya regions
(Deri Zuhrevi Hastaliklar Dernegi, 2016) Sahin, Nurhan; Bozdag, Zehra; Erkilic, Suna; Aydin, Nasuhi Engin; Sener, Serpil
Background and Design: Actinic (solar) keratosis (AK) is a precancerous, epidermal lesion, which develops in sensitive skin exposed to sun for a long period. AKs are divided into different histopathological subtypes. There is a link between the clinical progression of the histopathological subtypes, the degree of cellular atypia, and the precancerous nature of the lesion. Different series have reported that the rate of transformation of AK to squamous cell carcinoma (SCC) ranges between 12% and 20%. Materials and Methods: In this study, we reevaluated patients who were diagnosed with AK in the Pathology Departments of the Medical Faculties of Inonu and Gaziantep Universities over an eight-year period, and divided the patients into different histopathological subtypes. In addition, we investigated the association between the lesions, and basal cell carcinoma (BCC), SCC and both carcinomas. Results: 29,6% of cases were proliferative AK, 27% of cases were hypertrophic AK. 19% and 13% of all lesions was associated with BCC and SCC, respectively. Conclusion: In this study, we found that the most frequent subtype was proliferative AK and the most frequent nonmelanotic skin cancer was BCC associated with AK.

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