Yazar "Totan, Y" seçeneğine göre listele
Listeleniyor 1 - 14 / 14
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe The activities of serum adenosine deaminase and xanthine oxidase enzymes in Behcet's disease(Elsevier Science Bv, 2002) Sögüt, S; Aydin, E; Elyas, H; Aksoy, N; Özyurt, H; Totan, Y; Akyol, ÖBackground: Adenosine deaminase (AD) and xanthine oxidase (XO) are enzymes of purine catabolism that catalyze the conversion of adenosine to inosine, deoxyadenosine to deoxyinosine, hypoxanthine to xanthine and xanthine to Uric acid, respectively. AD is known to be an important enzyme in the maturation and function of T lymphocytes. The aim of this prospective study was to evaluate whether there are changes in serum AD activity as an index of T lymphocyte function in Behcet's disease (BD) which is known as having T cell-mediated immune response. Methods: A total of 32 patients and 26 sex- and age-matched healthy control subjects were analysed for AD and XO activities. The patients with BD were divided into two subgroups: BD with and without eye lesions. Twelve patients with complete BD and four patients with incomplete BD had eye complications. AD and XO activities in serum were measured with spectrophotometric methods. Re vults: There was a remarkable increase in AD activity and moderate increase in XO in patients with BD compared to controls indicating T cell activation and increased maturation. Serum AD activity of complete BD was higher than that of incomplete BD. There was no difference it) XO activity between the subgroups of BD. Significant positive correlation was found between AD and XO in BD, although there was no correlation in control group. Conclusions: The results indicate that increased AD and XO activities may provide an additional benefit for the diagnosis of BD and subtyping of the disease as having eye complication or not and complete and incomplete BD. Further studies are needed to bring to light the exact mechanism of AD and XO activity elevation. (C) 2002 Elsevier Science B.V. All rights reserved.Öğe Bilateral cataract surgery in adult and pediatric patients in a single session(Elsevier Science Inc, 2000) Totan, Y; Bayramlar, H; Çekiç, O; Aydin, E; Erten, A; Daglioglu, MCPurpose: To evaluate the results of bilateral simultaneous cataract surgery in adult and pediatric patients under local or general anesthesia. Setting: Department of Ophthalmology, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey. Methods: Eighty-two eyes of 41 patients were included in the study. Twelve of 17 pediatric patients with congenital cataract had bilateral simultaneous lensectomy, posterior capsulotomy, and anterior vitrectomy; 5 patients, aged 10 to 19 years, had bilateral extracapsular cataract extraction (ECCE) with posterior chamber intraocular lens (PC IOL) implantation. Forty-eight eyes of 24 adult patients had bilateral simultaneous ECCE with primary (43 eyes) or secondary (5 eyes) PC IOL implantation. Local anesthesia was administered to 20 adult patients by retrobulbar injection; the other cases were performed using general anesthesia. The procedures were treated as 2 separate surgeries in the same session; care was taken to ensure surgical asepsis. Results: No serious intraoperative complications occurred such as posterior capsule rupture, vitreous loss, endophthalmitis, and anesthesia-related problems. Of patients tested, 84.4% achieved a final best corrected visual acuity of 6/12 or better and 31.0%, of 6/6 or better. Conclusions: Simultaneous bilateral cataract surgery was not associated with an increased rate of complications, and visual results were good. If strict rules of surgical asepsis are followed, this may be a useful option in a variety of bilateral cases using general or local anesthesia. J Cataracr Refract Surg 2000; 26:1008-1011 (C) 2000 ASCRS and ESCRS.Öğe Bilateral retrobulbar neuritis following measles in an adult(Nature Publishing Group, 1999) Totan, Y; Çekiç, O[Abstract Not Available]Öğe Changes in oxidative status in silver nitrate induced corneal neovascularization.(Assoc Research Vision Ophthalmology Inc, 2000) Totan, Y; Aydin, E; Daglioglu, M; Ozyurt, H; Sogut, S[Abstract Not Available]Öğe Dislocation of a scleral-fixated posterior chamber intraocular lens into the anterior chamber associated with pseudophakic bullous keratopathy(Slack Inc, 2004) Aydin, E; Bayramlar, H; Totan, Y; Daglioglu, MC; Borazan, MA 48-year-old patient with a scleral-fixated posterior chamber intraocular lens had dislocation of the intraocular lens into the anterior chamber and associated pseudophakic buttons keratopathy. The patient underwent intraocular lens extraction and partial penetrating keratoplasty. Because an anterior chamber intraocular lens is easier to implant and has fewer complications, surgeons may want to consider this as the first choice for treatment. If the scleral-fixated posterior chamber intraocular lens is used, it must be implanted property and meticulously to avoid complications.Öğe Effect of caffeic acid phenethyl ester on corneal neovascularization in rats(Swets Zeitlinger Publishers, 2001) Totan, Y; Aydin, E; Çekiç, O; Daglioglu, MC; Borazan, M; Daglioglu, KPurpose. Caffeic acid phenethyl ester (CAPE), a biologically active component of propolis from honeybee hives, has potent antiinflammatory and antioxidant properties. We aimed to evaluate the ability of topically applied CAPE in comparison with known steroidal (dexamethasone sodium phosphate) and nonsteroidal (indomethacin) topical agents to reduce corneal neovascularization (CNV) induced by silver nitrate cauterization in rats. Methods. Following silver nitrate cauterization on both eyes, male rats were randomly assigned to the study and control groups, each consisting of ten rats. The inhibitory effects of the test drugs against a placebo (isotonic saline) on CNV were tested and compared to each other using a previously described method in which extent of neovascularization and burn stimulus intensity were scored by a masked examiner. Briefly, burn stimulus intensity was scored from 0 to + 3 according to the height of blister from corneal surface, and extent of neovascularization was recorded from 0 to + 6 according to the distance from limbus to the end point of CNV toward the central corneal burn. Results. The mean burn stimulus score were not different among the groups (P=0.807). Percent inhibition of CNV compared to the placebo control and its significance were 31.5%, P=0.011 for indomethacin; 56%, P<0.001 for dexamethasone; and 52%, P<0.001 for CAPE. Dexamethasone was significantly (P<0.05) more effective than indomethacin in inhibition of neovascular growth. CAPE was found to be superior (P<0.05) to indomethacin and almost as effective as (P>0.05) dexamethasone in reducing CNV. Conclusion. Topically applied CAPE was demonstrated to have an inhibitory effect, comparable to that of topical dexamethasone, on CNV in this rat model. Antiinflammatory and antioxidant properties of CAPE may contribute to its suppression on CNV.Öğe The effect of verapamil in the prevention of radiation-induced cataract(Elsevier Science Inc, 1999) Cengiz, M; Gürkaynak, M; Atahan, IL; Kilic, K; Totan, YPurpose: Cataract is an unavoidable complication when radiation therapy includes the lens, even in small doses. Alterations in the ion content of the lens were considered to play an essential role in cataract formation. In this experimental study, the effect of verapamil on ion concentrations within the irradiated lenses was investigated in rats. Methods and Materials: Forty female Wistar albino rats, each weighing 180-250 g, were divided into three groups: (a) radiation treated (n = 10); (b) no treatment (n = 10); (c) or a combination of radiation and verapamil (n = 20), Both the radiation group and verapamil-treated group received 5 Gy radiation to the cranium in a single fraction, including the eyes, within the irradiation volume. All animals were sacrificed by bleeding, 7.5 weeks posttreatment. Calcium, sodium, and potassium levels were measured in blood and in lens homogenates, However, for technical reasons, magnesium levels could only be studied in lens homogenates. Results: Potassium and sodium concentrations in lens homogenates did not differ in the control and radiation groups, but both were significantly lower in the verapamil-treated group (p = 0.001, p = 0.009, respectively). Calcium levels were higher in the radiation group and lower in the verapamil-treated group compared to the controls (p < 0.0001); magnesium levels did not differ (p = 0.37). Conclusion: Verapamil effectively decreased the lens calcium concentration, which is accepted as the key element in radiation cataractogenesis, It is therefore concluded that verapamil may reduce the risk of radiation-induced cataract formation. (C) 1999 Elsevier Science Inc.Öğe The efficacy of acetazolamide on visual functions in a patient with choroid metastasis of breast carcinoma(Medicom International, 2001) Sari, R; Camci, C; Kutlu, R; Totan, Y; Sevinc, A; Buyukberber, SBreast carcinoma is the most frequent cancer in women and is the second leading cause of death. Choroid metastasis of breast carcinoma can be found either at presentation or in remission. It is frequently encountered in disseminated breast cancer with multiple organ metastasis. It has been proposed that the oedema-reducing effect of acetazolamide is due to stimulated ion and fluid removal from the retina to the choroid. A 40-year-old female patient on adjuvant chemotherapy for breast cancer was found to have an isolated choroid metastasis. Clinical and radiological remission was achieved after orbital radiotherapy, chemotherapy and acetazolamide treatment. In this case report, we emphasise the possible beneficial effect of acetazolamide in patients with choroid metastasis.Öğe Evaluation of hemodynamic changes in the ophthalmic artery with color Doppler ultrasonography after strabismus surgery(Slack Inc, 2000) Bayramlar, H; Totan, Y; Çekiç, O; Yazicioglu, KM; Aydin, EPurpose: To investigate the blood flow changes in ophthalmic artery with color Doppler ultrasonography after strabismus surgery. Methods: Twenty eyes of 19 patients who underwent recession or resection surgery on two horizontal rectus muscles in 1 eye were examined using color Doppler ultrasonography preoperatively and 1 week and 1 month postoperatively. Measurements from both eyes of 16 age- and sex-matched normal subjects served as control data. The systolic maximum velocity, mean velocity, end-diastolic velocity, pulsatility index, and resistance index of the ophthalmic artery were determined. The Mann-Whitney U test was performed for comparison of the control and study group preoperatively for any hemodynamic parameter. Statistical comparison of the preoperative and postoperative measures in the study group was performed with Friedman's two-way analysis of variance. Results: No difference (P>.05) was observed preoperatively between the study and control groups for any hemodynamic parameter in the ophthalmic artery. Although the ophthalmic artery showed a slight increase in systolic maximum velocity 1 month postoperatively, there were no statistically significant differences (P>.05) in velocities or resistance in the ophthalmic artery at any interval. Conclusion: Two horizontal rectus muscle operations in a previously unoperated eye do not cause significant hemodynamic changes in the ophthalmic artery. However, further studies are needed to obtain more information about the effect of multiple vertical rectus muscle operations on the blood flow parameters of the ophthalmic artery.Öğe Heparin in the intraocular irrigating solution in pediatric cataract surgery(Elsevier Science Inc, 2004) Bayramlar, H; Totan, Y; Borazan, M\Purpose: To investigate the antiinflammatory effects of adding heparin sodium to the irrigating solution to prevent fibrinoid reaction and related long-term complications after pediatric cataract surgery. Setting: Department of Ophthalmology, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey. Methods: Thirty eyes of 18 children who had cataract or other ocular surgery were included in the study. Bilateral cataract surgery was performed in 20 eyes of 10 children and bilateral secondary intraocular lens (IOL) implantation in 4 eyes of 2 children (Group 1). Four eyes of 4 children had unilateral cataract surgery and 2 eyes of 2 children with previous perforating eye injury had synechiotomy and pupilloplasty (Group 2). Heparin sodium was added to the irrigating solution during surgery in 12 left eyes of children with bilateral surgery (Group 1a) and in all eyes in Group 2. Heparin sodium was not added during surgery in 12 right eyes of children having bilateral surgery (Group 1b, control). Early and late postoperative intraocular reactions were recorded and compared. Results: In Group la (heparin added), 6 eyes had less fibrinoid reaction and fewer related complications such as posterior synechias, pupil irregularity, and intraocular lens (IOL) decentration than the fellow right eyes. No eye in Group la having primary cataract surgery had hyphema or intraocular bleeding. Hyphema occurred on the first postoperative day in 1 eye in Group 1 a that had secondary IOL implantation. Conclusions: Adding heparin sodium to the irrigating solution decreased postoperative inflammatory and fibrinoid reactions and related complications such as synechias, pupil irregularity, and IOL decentration in pediatric cataract surgery. However, the use of heparin during surgery can be risky in eyes with a defective blood-aqueous barrier such as after previous ocular surgery.Öğe Incidence of keratoconus in subjects with vernal keratoconjunctivitis(Elsevier Science Inc, 2001) Totan, Y; Hepsen, IF; Çekiç, O; Gündüz, A; Aydin, EPurpose: To detect the incidence of keratoconus by videokeratography in patients with vernal keratoconjunctivitis (VKC) and to evaluate the clinical characteristics of VKC associated with keratoconus, Design: A prospective, cross-sectional (prevalence) study. Participants: Eighty-two consecutive subjects with the diagnosis of VKC, Methods: Both eyes of VKC subjects were investigated by videokeratography in comparison with slit-lamp biomicroscopy and keratometry, To detect keratoconus, corneal topography maps were examined with modified Robinowitz-McDonnell test. Main Outcome Measures: In this test, maps with central corneal power greater than 47.2 diopters and/or the inferosuperior asymmetry value greater than 1.4 were considered to have a keratoconus pattern. The findings of VKC were also recorded. Results: The distribution of clinical forms of VKC were as follows: 46.34% mixed, 43.90% palpebral, and 9.76% limbal types. Twenty-six (31.7%) of 82 subjects had complications with kerotopathy such as pseudogerontoxon, punctate keratitis, and shield ulcer. Forty-four eyes (26.8%) were detected as keratoconus by quantitative evaluation of videokeratography maps, 14 eyes (8.5%) by biomicroscopy, and 30 eyes (18.3%) by keratometry, The increased incidence of keratoconus was associated with male gender, long-standing disease, mixed and palpebral forms, and advanced corneal lesions. Conclusions: The higher incidence of keratoconus in our study compared with the previous reports may result from early detection of mild keratoconus by interpretation of color-coded videokeratographic maps with a sensitive quantitative method. (C) 2001 by the American Academy of Ophthalmology.Öğe Manual tunnel incision extracapsular cataract extraction using the sandwich technique(Amer Soc Cataract Refractive Surgery, 1999) Bayramlar, H; Çekiç, O; Totan, YSmall incision extracapsular cataract extraction (ECCE) using the sandwich technique is described. After capsulorhexis, hydrodissection, and hydrodelineation, the endonucleus is moved into the anterior chamber and extracted by sandwiching it between the irrigating vectis and iris spatula. In a series of 37 eyes, most achieved a best corrected visual acuity of 5/10 or better postoperatively. Complications were posterior capsule rupture, vitreous loss, and transient corneal edema. Small incision ECCE using the sandwich technique is safe, easy, and does not require expensive instrumentation.Öğe Plasma malondialdehyde and nitric oxide levels in age related macular degeneration(British Med Journal Publ Group, 2001) Totan, Y; Çekiç, O; Borazan, M; Uz, E; Sögüt, S; Akyol, ÖAims-To evaluate alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels in patients with exudative age related macular degeneration (ARMD). Methods-Plasma. nitrite plus nitrate concentrations as an index of plasma NO levels and plasma MDA level as a marker of lipid peroxidation were measured in patients with exudative ARMD and age and sex matched healthy subjects. Results-Significantly higher MDA and lower NO levels were detected in plasma of patients with ARMD compared with their controls (p=0.01, p=0.001, respectively). Conclusion-The results may support involvement of oxidative damage and vascular theory in the pathogenesis of ARMD as part of the ageing process.Öğe Small incision extracapsular cataract surgery with manual phacotrisection(Amer Soc Cataract Refractive Surgery, 2000) Hepsen, IF; Çekiç, O; Bayramlar, H; Totan, YPurpose: To evaluate the safety and efficacy of small incision extracapsular cataract extraction (ECCE) using the manual phacotrisection technique. Setting: Department of Ophthalmology, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey. Methods: Fifty-nine eyes of 54 patients had small incision ECCE by the manual phacotrisection technique. Mean follow-up was 10 months. After capsulorhexis and hydrodissection were performed, the endonucleus was prolapsed into the anterior chamber and trisected using an anteriorly positioned triangular trisector and posteriorly placed solid vectis. Pieces were extracted with a forceps through a small incision. Results: Postoperatively, best spectacle-corrected visual acuity of 20/40 or better was achieved in 48 eyes (83%) and of 20/25 or better in 28 eyes (47%). The most frequent intraoperative complication was posterior capsule rupture (n = 5). Of eyes that developed posterior capsule rupture, 3 had vitreous loss and 2 had implantation of an anterior chamber intraocular lens (IOL), in 44 eyes, the IOL was implanted in the bag and in 12 eyes, in the ciliary sulcus. The most significant postoperative complication was transient corneal edema, which developed in 32 eyes (54%). No permanent complications (e.g., corneal endothelial decompensation) occurred in any case. Conclusion: Manual phacotrisection has several advantages such as nucleus safety, less dependence on assistant personnel, the elimination of the phaco machine, and cost effectiveness. J Cataract Refract Surg 2000; 26:1048-1051 (C) 2000 ASCRS and ESCRS.
