Protective Role of Diospyros lotus L. in Cisplatin-Induced Cardiotoxicity: Cardiac Damage and Oxidative Stress in Rats

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridASKIN OZEK, DILAN/0000-0001-9075-4807
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidbasak, nese/ABH-5495-2020
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorOzek, Dilan Askin
dc.contributor.authorTaslidere, Asli
dc.contributor.authorCiftci, Osman
dc.contributor.authorSaral, Ozlem
dc.contributor.authorGul, Cemile Ceren
dc.date.accessioned2024-08-04T20:10:11Z
dc.date.available2024-08-04T20:10:11Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Cisplatin is a powerful chemotherapeutic drug that is used to treatment a wide variety of cancers. Despite clinical data demonstrating the cardiotoxic effect of cisplatin, few studies have been carried to improve the cardiotoxicity of cisplatin. In cisplatin-induced toxicity, oxidative stress plays a critical role. This study determined the effect of Diospyros lotus L. fruit (DL), a powerful antioxidant plant, on heart damage caused by cisplatin through histological examination and oxidative stress parameters. Materials and Methods: Twenty eight male rats were randomly divided into four groups. An isotonic solution was given to the control group. A single dose of 7 mg/kg cisplatin was administered intraperitoneally to the cisplatin group. 1.000 mg/kg DL was given by gavage for 10 days to the DL group. Cisplatin and DL were administered together in the same doses to the treatment group. Thiobarbituric acid reactive substances (TBARS) levels, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities, and total glutathione (GSH) level were measured in the heart tissue of the experimental rats. Histological examination was also performed to determine any damage to the hearts of the experimental rats. Results: While TBARS levels in the cisplatin group increased significantly, SOD, CAT, GPx activities, and total GSH level decreased significantly. TBARS levels decreased significantly and SOD, CAT, GPx activities and GSH levels increased with DL treatment. According to the histological examination, histopathological differences were observed in the cisplatin group. Histopathological findings were either absent or decreased in the DL-treated group. Conclusion: Results of the study showed that DL therapy reduced oxidative stress and histological changes caused by cisplatin. DL could be a potential candidate for reducing cardiac damage caused by cisplatin.en_US
dc.identifier.doi10.4274/tjps.galenos.2021.84555
dc.identifier.endpage137en_US
dc.identifier.issn1304-530X
dc.identifier.issn2148-6247
dc.identifier.issue2en_US
dc.identifier.pmid35509232en_US
dc.identifier.scopus2-s2.0-85129934187en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage132en_US
dc.identifier.trdizinid515899en_US
dc.identifier.urihttps://doi.org/10.4274/tjps.galenos.2021.84555
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/515899
dc.identifier.urihttps://hdl.handle.net/11616/92647
dc.identifier.volume19en_US
dc.identifier.wosWOS:000795096700003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiospyros lotusen_US
dc.subjectcisplatinen_US
dc.subjectcardiotoxicityen_US
dc.subjectoxidative stressen_US
dc.titleProtective Role of Diospyros lotus L. in Cisplatin-Induced Cardiotoxicity: Cardiac Damage and Oxidative Stress in Ratsen_US
dc.typeArticleen_US

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