Epidemiological Markers in Adult Glial Tumors: A Single-Center Experience and The Utility of the Classification System

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dc.authoridBayatli, Eyup/0000-0001-6246-4247
dc.authoridtetik, bora/0000-0001-7696-7785
dc.authorwosidBayatli, Eyup/AGH-1317-2022
dc.authorwosidtetik, bora/AAA-8841-2021
dc.contributor.authorBayatli, Eyup
dc.contributor.authorTetik, Bora
dc.contributor.authorBuyuktepe, Murat
dc.contributor.authorTokdemir, Nurhan
dc.contributor.authorGuner, Yahya Efe
dc.contributor.authorGuney, Yildiz
dc.contributor.authorUgur, Hasan Caglar
dc.date.accessioned2024-08-04T20:10:12Z
dc.date.available2024-08-04T20:10:12Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE This study aimed to investigate the etiology of gliomas and determine the utility of the World Health Organization (WHO) classification of central nervous system tumors. METHODS Patients aged >= 18 years who underwent surgery or were followed up for filial tumors between January 2017 and January 2020 and whose pathology reports indicated grade II-IV gliomas were included in the study. Patients with missing data, pathology results incompatible with grade II-IV gliomas, and unavailable standard molecular/genetic tumor profiles were excluded from the study. RESULTS The results of the standard histopathological and molecular/genetic analyses were evaluated retrospectively without any additional examinations. Data from 259 patients were evaluated. Of these, 8 patients who did not meet the criteria for glioma pathology and 27 patients with not otherwise specified molecular pathological examination results were excluded from the study. Patients were evaluated in detail regarding demographic and admission data, pathology analysis, potential risk factors, and survival results. CONCLUSION Many factors, particularly high blood glucose levels, sedentary lifestyle, and radiofrequency electromagnetic field exposure, appear to have a relationship with glioma etiology. 'There is a major heterogeneity and lack of standardized efficient laboratory procedures that may interfere with reliable standard molecular results. False positive molecular markers consist a major classification issue and methods that reflect the requirements of the WHO classification may themselves be inadequate to establish a profile with adequate sensitivity. The development of more practical and accessible methods in addition to standardized, rapid, and reliable methods for testing multiple markers at an acceptable cost is urgently needed.en_US
dc.identifier.doi10.5505/tjo.2021.3441
dc.identifier.endpage114en_US
dc.identifier.issn1300-7467
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85134211412en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage105en_US
dc.identifier.trdizinid1136674en_US
dc.identifier.urihttps://doi.org/10.5505/tjo.2021.3441
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1136674
dc.identifier.urihttps://hdl.handle.net/11616/92659
dc.identifier.volume37en_US
dc.identifier.wosWOS:000767310000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClassificationen_US
dc.subjectepidemiologyen_US
dc.subjectgliomaen_US
dc.subjectmolecularen_US
dc.subjecttumoren_US
dc.titleEpidemiological Markers in Adult Glial Tumors: A Single-Center Experience and The Utility of the Classification Systemen_US
dc.typeArticleen_US

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