Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in rats
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Date
2003
Journal Title
Journal ISSN
Volume Title
Publisher
Academic Press Ltd- Elsevier Science Ltd
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
The effect of oral erdosteine on tissue malondialdehyde (MDA) and nitric oxide (NO) levels, and catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities are investigated in the cisplatin model of acute renal failure in rats. A single dose of cisplatin caused kidney damage manifested by kidney histology as well as increases in plasma creatinine and blood urea nitrogen (BUN) levels. Treatment with free radical scavenger erdosteine attenuated increases in plasma creatinine and BUN, and tissue MDA and NO levels, and provided a histologically-proven protection against cisplatin-induced acute renal failure. Erdosteine also reduced depletion in the tissue CAT, GSH-Px, and SOD activities. These results show that erdosteine may be a promising drug for protection against cisplatin-induced nephrotoxicity. However, further studies with different doses of erdosteine are warranted for clarifying the issue. (C) 2002 Published by Elsevier Science Ltd.
Description
Keywords
erdosteine, cisplatin nephrotoxicity, nitric oxide, free radicals
Journal or Series
Pharmacological Research
WoS Q Value
Q3
Scopus Q Value
Q1
Volume
47
Issue
2
