Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in rats

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dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.contributor.authorYildirim, Z
dc.contributor.authorSogut, S
dc.contributor.authorOdaci, E
dc.contributor.authorIraz, M
dc.contributor.authorOzyurt, H
dc.contributor.authorKotuk, M
dc.contributor.authorAkyol, O
dc.date.accessioned2024-08-04T20:13:14Z
dc.date.available2024-08-04T20:13:14Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe effect of oral erdosteine on tissue malondialdehyde (MDA) and nitric oxide (NO) levels, and catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities are investigated in the cisplatin model of acute renal failure in rats. A single dose of cisplatin caused kidney damage manifested by kidney histology as well as increases in plasma creatinine and blood urea nitrogen (BUN) levels. Treatment with free radical scavenger erdosteine attenuated increases in plasma creatinine and BUN, and tissue MDA and NO levels, and provided a histologically-proven protection against cisplatin-induced acute renal failure. Erdosteine also reduced depletion in the tissue CAT, GSH-Px, and SOD activities. These results show that erdosteine may be a promising drug for protection against cisplatin-induced nephrotoxicity. However, further studies with different doses of erdosteine are warranted for clarifying the issue. (C) 2002 Published by Elsevier Science Ltd.en_US
dc.identifier.doi10.1016/S1043-6618(02)00282-7
dc.identifier.endpage156en_US
dc.identifier.issn1043-6618
dc.identifier.issn1096-1186
dc.identifier.issue2en_US
dc.identifier.pmid12543063en_US
dc.identifier.scopus2-s2.0-0037331412en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://doi.org/10.1016/S1043-6618(02)00282-7
dc.identifier.urihttps://hdl.handle.net/11616/93492
dc.identifier.volume47en_US
dc.identifier.wosWOS:000180923900007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Science Ltden_US
dc.relation.ispartofPharmacological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecterdosteineen_US
dc.subjectcisplatin nephrotoxicityen_US
dc.subjectnitric oxideen_US
dc.subjectfree radicalsen_US
dc.titleOral erdosteine administration attenuates cisplatin-induced renal tubular damage in ratsen_US
dc.typeArticleen_US

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