Hepatitis B virus DNA levels according to the Child-Pugh stage in patients with cirrhosis
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background and Aims: To compare hepatitis B virus DNA levels accordingto Child-Pugh stage in patients who developed cirrhosis due tohepatitis B virus. Materials and Methods: This study was conductedas retrospectively. Patients who were newly diagnosed with cirrhosisdue to hepatitis B virus infection were included. hepatitis B virus DNA,albumin, bilirubin, and international normalization rate levels werecompared according to the Child-Pugh Scores. Results: A total of 90patients (60 males, 30 females) with a mean age of 52.22±9.42 yearswere included in this study. Each group consisted of 30 patients. HepatitisB virus DNA level was significantly lower in the Group A comparedwith the Group B and C (p=0.031). A significant difference was observedbetween the groups in terms of Child-Pugh scores, albumin, bilirubin,and international normalization rate levels (all p=0.0001). Albuminlevels were lower and international normalization rate levels werehigher in the Group B and C (all p<0.05). Ascites and encephalopathywere detected in 42 (%46,7) and 79 (87,8) patients, respectively. Bothascites and encephalopathy were more common in the Group C. Conclusion:Hepatitis B virus DNA level was significantly lower and albuminand bilirubin levels were relatively normal in the early stages of cirrhosisdue to hepatitis B virus infection. By contrast, ascites and encephalopathywere more common, bilirubin and international normalization ratelevels were elevated, and albumin levels were lower in the later stages(Child-Pugh B and C) of chronic hepatitis B.
Açıklama
Anahtar Kelimeler
Kaynak
Akademik Gastroenteroloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
17
Sayı
2
