Protective Effect of Amifostine on Radiotherapy-Applied Cardiovascular Tissue

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dc.contributor.authorTaylan, Gokay
dc.contributor.authorCaloglu, Murat
dc.contributor.authorCaloglu, Vuslat Yurut
dc.contributor.authorYalta, Tulin
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorYalta, Kenan
dc.contributor.authorAktoz, Meryem
dc.date.accessioned2026-04-04T13:33:04Z
dc.date.available2026-04-04T13:33:04Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: The present study evaluates the protective effect of amifostine (AMI) on acute toxicity in large vessels and the heart in rats with radiotherapy (RT) applied to the thorax. Methods: Twenty-one Wistar albino rats were randomly assigned to 3 groups: Alone RT (n = 7), amifostine plus RT (AMI+RT, n = 7), and control (n = 7) groups. The rats in the RT and AMI+RT groups received a single dose of 20 Gy radiation to the entire thorax. Prior to irradiation, AMI was administered intraperitoneally at a dose of 200 mg/kg, 30 minutes before the procedure. Five days after irradiation, the levels of p53, CD68, and COX in the vascular tissue (aorta) were measured, along with the levels of malondialdehyde (MDA) and glutathione (GSH) in the aortic and heart tissues. Results: The results showed that the level of MDA significantly increased after irradiation, but GSH levels did not change (P < .001 and P = 0.138). Malondialdehyde levels were significantly reduced by AMI, and GSH levels increased (P = .031 and P = .007). When comparing the control group with AMI + RT, MDA and glutathione levels were similar (P = .314 and P = .136). Histopathological evaluation revealed increased cellular inflammation (P = .002) and vascular damage (P = .015) in aortic tissue after thoracic RT irradiation, but no difference in terms of myofibrosis (P = .901) in heart tissue. Conclusion: AMI has a radioprotective and antioxidant effect against RT-induced cardiovascular toxicity.
dc.description.sponsorshipInstitutional Scientific Research Projects Unit
dc.description.sponsorshipFunding: The authors thank the Institutional Scientific Research Projects Unit fortheir support.
dc.identifier.doi10.14744/AnatolJCardiol.2025.4996
dc.identifier.endpage361
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue7
dc.identifier.orcid0000-0003-2102-6034
dc.identifier.pmid40257246
dc.identifier.scopus2-s2.0-105014648104
dc.identifier.scopusqualityQ3
dc.identifier.startpage355
dc.identifier.trdizinid1361138
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2025.4996
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1361138
dc.identifier.urihttps://hdl.handle.net/11616/108882
dc.identifier.volume29
dc.identifier.wosWOS:001529662800007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectAmifostine
dc.subjectcardiovascular disease
dc.subjectprevention
dc.subjectradiotherapy
dc.titleProtective Effect of Amifostine on Radiotherapy-Applied Cardiovascular Tissue
dc.typeArticle

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