Relationship between nitric oxide levels and delirium in patients with coronary bypass operation
Küçük Resim Yok
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Delirium is an acute brain failure which is related to various pathological conditions. Although there are some ideas about etiopathogenesis of delirium, some points have not been cleared yet. We aimed to investigate relationship between nitric oxide (NO) levels and delirium prospectively in patients with in coronary bypass operation. Methods: We included 50 (37 males, 13 females, ages: 37-75, mean±sd= 59.8±10.6) patients with coronary illnesses who will undergo bypass operation. Patients with dementia and any systemic disease, except hypertension and coronary artery disease, were excluded from study. Smoking was not allowed at least 7 days prior to operation. We diagnosed delirium using DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders) criteria. Delirium Rating Scale was used to estimate delirium severity. Blood samples were taken pre-operationally and post operationally. Patients were divided into two groups as delirium group and nondelirium group. We compared the two groups according to NO levels. Results: 12 of the 50 patients had delirium. While there was no significant difference among blood NO levels pre-operationally between two groups, the NO levels were statistically higher in the delirium group than the nondelirium group. Conclusion: Our study is important since it is first study that investigated the relationship between NO and delirium. Blood NO levels become higher in patients who developed post operationally delirium. These findings can be explained by increased NO production in brain tissue due to increased cerebral ischemia and/or increased response to oxidative stress during operation.
Açıklama
Anahtar Kelimeler
Brain ischemia, Coronary bypass operation, Delirium, Nitric oxide
Kaynak
Klinik Psikofarmakoloji Bulteni
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
14
Sayı
4
