Relationship between nitric oxide levels and delirium in patients with coronary bypass operation

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dc.authorscopusid15019846900
dc.authorscopusid6602953248
dc.authorscopusid34770872600
dc.authorscopusid7006785766
dc.authorscopusid6603344865
dc.authorscopusid55903323700
dc.authorscopusid8932188900
dc.contributor.authorSezer Ö.
dc.contributor.authorKarlida? R.
dc.contributor.authorKarabulut A.B.
dc.contributor.authorÖzcan C.
dc.contributor.authorNisano?lu V.
dc.contributor.authorTürköz Y.
dc.contributor.authorBut A.
dc.date.accessioned2024-08-04T20:00:37Z
dc.date.available2024-08-04T20:00:37Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Delirium is an acute brain failure which is related to various pathological conditions. Although there are some ideas about etiopathogenesis of delirium, some points have not been cleared yet. We aimed to investigate relationship between nitric oxide (NO) levels and delirium prospectively in patients with in coronary bypass operation. Methods: We included 50 (37 males, 13 females, ages: 37-75, mean±sd= 59.8±10.6) patients with coronary illnesses who will undergo bypass operation. Patients with dementia and any systemic disease, except hypertension and coronary artery disease, were excluded from study. Smoking was not allowed at least 7 days prior to operation. We diagnosed delirium using DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders) criteria. Delirium Rating Scale was used to estimate delirium severity. Blood samples were taken pre-operationally and post operationally. Patients were divided into two groups as delirium group and nondelirium group. We compared the two groups according to NO levels. Results: 12 of the 50 patients had delirium. While there was no significant difference among blood NO levels pre-operationally between two groups, the NO levels were statistically higher in the delirium group than the nondelirium group. Conclusion: Our study is important since it is first study that investigated the relationship between NO and delirium. Blood NO levels become higher in patients who developed post operationally delirium. These findings can be explained by increased NO production in brain tissue due to increased cerebral ischemia and/or increased response to oxidative stress during operation.en_US
dc.identifier.endpage190en_US
dc.identifier.issn1017-7833
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-11844280901en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage185en_US
dc.identifier.urihttps://hdl.handle.net/11616/90854
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofKlinik Psikofarmakoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain ischemiaen_US
dc.subjectCoronary bypass operationen_US
dc.subjectDeliriumen_US
dc.subjectNitric oxideen_US
dc.titleRelationship between nitric oxide levels and delirium in patients with coronary bypass operationen_US
dc.title.alternativeKoroner bypass ameliyati geçiren hastalarda deliryum gelişiminin nitrik oksit düzeyleriyle i?lişkisien_US
dc.typeArticleen_US

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