Preparation, characterization, and evaluation of multi-biofunctional properties of a novel chitosan-carboxymethylcellulose-Pluronic P123 hydrogel membranes loaded with tetracycline hydrochloride
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Herein, we report a multifunctional hydrogel membrane with good mechanical properties, excellent antioxidant efficiency, and broad-spectrum antimicrobial activity. For this purpose, a series of chitosan-carboxymethyl cellulose-Pluronic P123 (CHT-CMC-P123) hydrogel membranes were prepared by blending various tetracycline hydrochloride (TCH) contents. The physicochemical and biological properties of CHT-CMC-P123 membranes were comprehensively investigated. With the increase of TCH content from 5 % to 20 %, hydrogel membranes presented a decreased water contact angle from 18.96 degrees to 11.24 degrees, and a decreased water vapor transmission rate from 171.8 to 156.1 g/m2 h. Besides, with the increase of TCH content (5-20 %), the tensile strength (0.31-0.11 MPa) and elongation at break (10.57-4.82 %) of hydrogel membranes decreased while their thickness increased (113.5-324.3 mu m). The data show that the release of TCH reached equilibrium after 26 days, with a cumulative percentage of approximately 28 %-87 %. Moreover, the hydrogel membranes exhibited a high antioxidant ca-pacity of-92 % for DPPH radical. Importantly, the incorporation of TCH significantly (-2.3 fold) enhanced the antimicrobial activity of the hydrogel membranes against Gram-positive, and Gram-negative bacteria and yeast. Based on our findings, these hydrogel membranes with superior properties may serve as effective food packaging and wound healing materials.
Açıklama
Anahtar Kelimeler
Chitosan, carboxymethyl cellulose, Pluronic, P123, Hydrogel membrane, Tetracycline release, Antioxidant and antimicrobial activity
Kaynak
International Journal of Biological Macromolecules
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
222
