Preparation, characterization, and evaluation of multi-biofunctional properties of a novel chitosan-carboxymethylcellulose-Pluronic P123 hydrogel membranes loaded with tetracycline hydrochloride

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dc.authoridUlu, Ahmet/0000-0002-4447-6233
dc.authorwosidUlu, Ahmet/L-5180-2016
dc.contributor.authorUlu, Ahmet
dc.contributor.authorAygun, Tugba
dc.contributor.authorBirhanli, Emre
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:53:06Z
dc.date.available2024-08-04T20:53:06Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHerein, we report a multifunctional hydrogel membrane with good mechanical properties, excellent antioxidant efficiency, and broad-spectrum antimicrobial activity. For this purpose, a series of chitosan-carboxymethyl cellulose-Pluronic P123 (CHT-CMC-P123) hydrogel membranes were prepared by blending various tetracycline hydrochloride (TCH) contents. The physicochemical and biological properties of CHT-CMC-P123 membranes were comprehensively investigated. With the increase of TCH content from 5 % to 20 %, hydrogel membranes presented a decreased water contact angle from 18.96 degrees to 11.24 degrees, and a decreased water vapor transmission rate from 171.8 to 156.1 g/m2 h. Besides, with the increase of TCH content (5-20 %), the tensile strength (0.31-0.11 MPa) and elongation at break (10.57-4.82 %) of hydrogel membranes decreased while their thickness increased (113.5-324.3 mu m). The data show that the release of TCH reached equilibrium after 26 days, with a cumulative percentage of approximately 28 %-87 %. Moreover, the hydrogel membranes exhibited a high antioxidant ca-pacity of-92 % for DPPH radical. Importantly, the incorporation of TCH significantly (-2.3 fold) enhanced the antimicrobial activity of the hydrogel membranes against Gram-positive, and Gram-negative bacteria and yeast. Based on our findings, these hydrogel membranes with superior properties may serve as effective food packaging and wound healing materials.en_US
dc.identifier.doi10.1016/j.ijbiomac.2022.10.049
dc.identifier.endpage2682en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid36220402en_US
dc.identifier.scopus2-s2.0-85141104810en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2670en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2022.10.049
dc.identifier.urihttps://hdl.handle.net/11616/100973
dc.identifier.volume222en_US
dc.identifier.wosWOS:000892275700003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosanen_US
dc.subjectcarboxymethyl celluloseen_US
dc.subjectPluronicen_US
dc.subjectP123en_US
dc.subjectHydrogel membraneen_US
dc.subjectTetracycline releaseen_US
dc.subjectAntioxidant and antimicrobial activityen_US
dc.titlePreparation, characterization, and evaluation of multi-biofunctional properties of a novel chitosan-carboxymethylcellulose-Pluronic P123 hydrogel membranes loaded with tetracycline hydrochlorideen_US
dc.typeArticleen_US

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