Synthesis of benzotriazole-amino acid-benzenesulfonamide conjugates and phenylsulfonyl-dipeptides

dc.contributor.authorEzugwu, James Anayochukwu
dc.contributor.authorKucukbay, Hasan
dc.date.accessioned2026-04-04T13:31:23Z
dc.date.available2026-04-04T13:31:23Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractL-Amino acids were converted into sulfonamides by reaction with phenylsulfonyl chloride in a basic medium. Subsequent treatment of these sulfonamides with 1H-benzotriazole (BtH) and thionyl chloride at room temp erature yielded benzotriazole-amino acid-benzenesulfonamide conjugates with yields ranging from 42% to 68%. Furthermore, the reaction of the benzotriazole derivatives with free glycine and free phenylalanine resulted in the formation of (phenylsulfonyl)dipeptides.
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey) [E-21514107-115.02-612434/2221]; Idot;nonu University, Turkey [FBG-2024-3240]
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey) Project No: E-21514107-115.02-612434/2221 Program 2024/1 and & Idot;nonu University, Turkey (BAPB- Grand No-FBG-2024-3240) was acknowledged by the authors for funding this research work at Inonu University Malatya, Turkey.
dc.identifier.doi10.24820/ark.5550190.p012.429
dc.identifier.issn1551-7004
dc.identifier.issn1551-7012
dc.identifier.scopus2-s2.0-105030822101
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.24820/ark.5550190.p012.429
dc.identifier.urihttps://hdl.handle.net/11616/108774
dc.identifier.wosWOS:001667189800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherArkat Usa Inc
dc.relation.ispartofArkivoc
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectBenzensulfonamide
dc.subjectbenzotriazole
dc.subjectL-amino acids
dc.subjectsynthesis
dc.titleSynthesis of benzotriazole-amino acid-benzenesulfonamide conjugates and phenylsulfonyl-dipeptides
dc.typeArticle

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