Design of an electrochemical sensor based on 3-thiophene methanol and 3-methylthiophene supported molecularly imprinted polymer for the sensitive and selective detection of levothyroxine

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dc.contributor.authorYayan, Emrah
dc.contributor.authorKazici, Dilek
dc.contributor.authorSavan, Ebru Kuyumcu
dc.date.accessioned2026-04-04T13:34:55Z
dc.date.available2026-04-04T13:34:55Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractLevothyroxine (L-T4) is the most frequently prescribed drug to treat thyroid hormone deficiency. Herein, a levothyroxine-specific sensor was designed using the molecular imprinting method to increase the selectivity of the target molecule on the electrode surface and prevent interference effects. 3-thiophene methanol (3-TMeOH) and 3-methyl thiophene (3-MT) monomers were electro-polymerized as molecularly imprinted polymer (MIP) on the surface of a glassy carbon electrode (GCE) in the presence of L-T4. Gaps were created on the surface of the designed electrode to fit the target molecule by removing L-T4 molecules. This way, L-T4-specific selective structures were formed on the sensors' surface. The results showed that under optimized conditions, the fabricated modified sensor (3-TMeOH/3-MT@MIP/GCE) exhibited a linear response in the concentration range of 1.0-5.7 mu M with limit of determination, limit of quantitation, and sensitivity values of 1.83 nM, 5.50 nM, and 0.0023 A.L.mmol- 1.cm- 2, respectively. The analytical method validation process of the voltammetric determination method using the sensor selective to L-T4 was completed following the method's intended use. The designed modified sensor exhibited high sensitivity, repeatability, excellent stability, selectivity, and high precision and accuracy.
dc.description.sponsorshipInonu University [FOA-2021-2690]
dc.description.sponsorshipThe authors acknowledge the financial support of the Inonu University Research Fund Unit for priority area projects (Grant no. FOA-2021-2690) .
dc.identifier.doi10.1016/j.microc.2025.115192
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-105015186042
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.microc.2025.115192
dc.identifier.urihttps://hdl.handle.net/11616/109494
dc.identifier.volume218
dc.identifier.wosWOS:001568804600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMicrochemical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectElectroanalytical sensor
dc.subjectHypothyroidism
dc.subjectLevothyroxine
dc.subjectMolecularly imprinted polymer
dc.subjectVoltammetry
dc.titleDesign of an electrochemical sensor based on 3-thiophene methanol and 3-methylthiophene supported molecularly imprinted polymer for the sensitive and selective detection of levothyroxine
dc.typeArticle

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