Mechanical properties and cytotoxicity of hydroxyapatite based bone grafts applied mechanics and materials
Küçük Resim Yok
Dosyalar
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Applied Mechanics and Materials
Erişim Hakkı
info:eu-repo/semantics/embargoedAccess
Özet
Hydroxyapatite (HA) based bone grafts were synthesized by sol-gel method at various pH values 5, 7, 9 and 12, respectively. In order to ascertain the influence of the obtained bone grafts on the morphology, sinterability and mechanical properties, each composition was sintered at 11500C, and quantitative phase analysis was characterized by XRD and FTIR. The microstructures were studied via SEM-EDX and the validation of mechanical properties was evaluated by compression and Vickers hardness tests. The density of HA synthesis samples with different pH values before and after sintering were measured. Besides, the cytotoxicity analysis were conducted for all grafts having various pH values. The experimental results revealed that the density and mechanical strenght of HA based bone grafts were increased with increasing pH value. The highest hardness and strength were obtained for the samples having pH=12. Furthermore, the samples with pH=12 exhibited the best densification and properties when compared to the samples at pH of 5, 7 and 9. The cytotoxicity tests also indicated that the pH=7-12 value showed no toxicity to osteoblast cells at 0,1 and 0,3 μM concentration, whereas HA synthesis sample at pH=5 value with 0,3 μM concentration induced significantly and reduced cell viability.
Açıklama
Anahtar Kelimeler
Kaynak
Applied Mechanics and Materials
WoS Q Değeri
Scopus Q Değeri
Cilt
319
Sayı
Künye
Demirel, M. Aksakal, B. Başak, N. Mechanical properties and cytotoxicity of hydroxyapatite based bone grafts applied mechanics and materials. Applied Mechanics and Materials. 319:134-139.
