Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-?, transforming growth factor-?3 levels in the blood and tissues of pediatric patients with burns

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dc.authoridDemircan, Mehmet/0000-0002-4022-1276
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridGURUNLUOGLU, SEMRA/0000-0002-9737-859X
dc.authoridTasci, Aytac/0000-0002-4024-5219
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.contributor.authorDemircan, Mehmet
dc.contributor.authorGurunluoglu, Kubilay
dc.contributor.authorBag, Harika Gozde Gozukara
dc.contributor.authorKocbiyik, Alper
dc.contributor.authorGul, Mehmet
dc.contributor.authorUremis, Nuray
dc.contributor.authorGul, Semir
dc.date.accessioned2024-08-04T20:10:03Z
dc.date.available2024-08-04T20:10:03Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: We aimed to evaluate the effects of two different burn dressings, hydrofiber with a silver (HFAg) and polylactic membrane (PLM), on altering the levels of important biomarkers Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-alpha), Transforming growth factor-beta(3) (TGF-beta(3)) in blood and burnt tissue in children with second-degree burns. METHODS: Children between the ages of one to 16 years, with 25-50% second-degree partial-thickness burns of the total body surface area were included in this study. Patients in the PLM group were dressed with PLM in a typical way according to the manual. The HFAg group was dressed with HFAg and a sterile cover. During and at the end of the 21-day treatment, blood and skin tissue samples were taken from the two burn and control groups. IL-6, TNF-alpha, and TGF-beta beta(3) levels were evaluated in blood and tissue samples from all groups, and the results were analyzed statistically. RESULTS: In the PLM group, IL-6 and TNF-alpha levels decreased early days in both serum and tissue samples to reach normal ranges compared with the HFAg group. In the PLM group, TGF-beta(3) levels were elevated than in other groups for two weeks. CONCLUSION: In this study, we found that PLM controls inflammation earlier in both systemic and burn tissue. We also found that PLM increased the level of TGF-beta(3), which may be associated with the prevention of the development of hypertrophic scar in the burn wound, in the blood and burn tissue during this study.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [TSA-2018-1400]en_US
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit supported this project financially by TSA-2018-1400 project code.en_US
dc.identifier.doi10.14744/tjtes.2020.30483
dc.identifier.endpage131en_US
dc.identifier.issn1306-696X
dc.identifier.issue1en_US
dc.identifier.pmid33394485en_US
dc.identifier.scopus2-s2.0-85099428890en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage122en_US
dc.identifier.trdizinid517003en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2020.30483
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/517003
dc.identifier.urihttps://hdl.handle.net/11616/92579
dc.identifier.volume27en_US
dc.identifier.wosWOS:000604992400021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBurnsen_US
dc.subjectchildrenen_US
dc.subjectdressingen_US
dc.subjectIL-6en_US
dc.subjecthydrofiber with silveren_US
dc.subjectpolylactic membraneen_US
dc.subjectTNF-alphaen_US
dc.subjectTGF-betaen_US
dc.titleImpaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-?, transforming growth factor-?3 levels in the blood and tissues of pediatric patients with burnsen_US
dc.typeArticleen_US

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