Can Mean Platelet Volume be an Inflammatory Marker in Pediatric Diabetic Ketoacidosis?
Küçük Resim Yok
Dosyalar
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study explores the association between mean platelet volume (MPV) and other hematological parameters in children with diabetic ketoacidosis (DKA), aiming to identify hematological changes and their implications for management and treatment strategies in pediatric type 1 diabetes mellitus (T1DM). In a retrospective, two-center analysis of 323 children, participants were categorized into three groups: DKA, T1DM without ketoacidosis, and healthy controls (95). Hematological parameters and HbA1c levels were collected. Blood pH levels classified DKA severity, and statistical analyses included One-way ANOVA, correlation tests, receiver operating characteristic curve analysis, and logistic regression to assess the predictive value of hematological parameters for DKA. No significant demographic differences were noted among the groups. Patients with DKA exhibited significantly lower MPV and higher neutrophil-to-lymphocyte ratio (NLR) compared with both patients with T1DM without ketoacidosis and healthy controls. Logistic regression showed MPV ≤9.35 and NLR ≥2.73 significantly increased DKA risk. This study demonstrated a significant relationship between DKA and altered hematological parameters (MPV and NLR) in pediatric patients, highlighting their potential as markers for early detection and risk assessment of DKA.
Açıklama
Yıl : 2024 Cilt : 5 Sayı : 4 Sayfa : 130-135 Metin Dili : İngilizce
Anahtar Kelimeler
Diabetes mellitus, mean platelet volume, diabetic ketoacidosis
Kaynak
The journal of pediatric academy (Online)
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
4
Künye
TRABZON, G., ÇİÇEK, D., GÜNGÖR, Ş., DEMİRAY, Ş., YAZARLI, E., GÜLLÜ, U. U., EL, Ç. (2024). Can Mean Platelet Volume be an Inflammatory Marker in Pediatric Diabetic Ketoacidosis?. The journal of pediatric academy (Online), 5(4),130-135. doi.org/10.4274/jpea.2024.352
