Can Mean Platelet Volume be an Inflammatory Marker in Pediatric Diabetic Ketoacidosis?

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dc.contributor.authorTrabzon, Gül
dc.contributor.authorÇiçek, Dilek
dc.contributor.authorGüllü, Şeyma Demiray
dc.contributor.authorYazarlı, Esra
dc.contributor.authorGüllü, Ufuk Utku
dc.contributor.authorEl, Çiğdem
dc.date.accessioned2026-02-19T11:12:13Z
dc.date.available2026-02-19T11:12:13Z
dc.date.issued2024
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionYıl : 2024 Cilt : 5 Sayı : 4 Sayfa : 130-135 Metin Dili : İngilizce
dc.description.abstractThis study explores the association between mean platelet volume (MPV) and other hematological parameters in children with diabetic ketoacidosis (DKA), aiming to identify hematological changes and their implications for management and treatment strategies in pediatric type 1 diabetes mellitus (T1DM). In a retrospective, two-center analysis of 323 children, participants were categorized into three groups: DKA, T1DM without ketoacidosis, and healthy controls (95). Hematological parameters and HbA1c levels were collected. Blood pH levels classified DKA severity, and statistical analyses included One-way ANOVA, correlation tests, receiver operating characteristic curve analysis, and logistic regression to assess the predictive value of hematological parameters for DKA. No significant demographic differences were noted among the groups. Patients with DKA exhibited significantly lower MPV and higher neutrophil-to-lymphocyte ratio (NLR) compared with both patients with T1DM without ketoacidosis and healthy controls. Logistic regression showed MPV ≤9.35 and NLR ≥2.73 significantly increased DKA risk. This study demonstrated a significant relationship between DKA and altered hematological parameters (MPV and NLR) in pediatric patients, highlighting their potential as markers for early detection and risk assessment of DKA.
dc.identifier.citationTRABZON, G., ÇİÇEK, D., GÜNGÖR, Ş., DEMİRAY, Ş., YAZARLI, E., GÜLLÜ, U. U., EL, Ç. (2024). Can Mean Platelet Volume be an Inflammatory Marker in Pediatric Diabetic Ketoacidosis?. The journal of pediatric academy (Online), 5(4),130-135. doi.org/10.4274/jpea.2024.352
dc.identifier.doi10.4274/jpea.2024.352
dc.identifier.endpage135
dc.identifier.issue4
dc.identifier.startpage130
dc.identifier.urihttps://hdl.handle.net/11616/106390
dc.identifier.volume5
dc.institutionauthorGüngör, Şükrü
dc.institutionauthorid0000-0002-0433-5970
dc.language.isoen
dc.publisherİnönü Üniversitesi
dc.relation.ispartofThe journal of pediatric academy (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes mellitus
dc.subjectmean platelet volume
dc.subjectdiabetic ketoacidosis
dc.titleCan Mean Platelet Volume be an Inflammatory Marker in Pediatric Diabetic Ketoacidosis?
dc.typeArticle

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