Determination of the Physicochemical Properties of Piroxicam

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dc.authoridKaplan, Ozan/0000-0001-7429-9349
dc.authoridnenni, merve/0000-0003-3165-1060
dc.authoridKAYNAK, Mustafa Sinan/0000-0003-2917-2407
dc.authoridSahin, Selma/0000-0001-5736-5906
dc.authoridCelebier, Mustafa/0000-0001-7712-5512
dc.authorwosidKaplan, Ozan/A-7969-2019
dc.authorwosidnenni, merve/AAC-8971-2020
dc.authorwosidKAYNAK, Mustafa Sinan/D-9453-2019
dc.contributor.authorCelebier, Mustafa
dc.contributor.authorNenni, Merve
dc.contributor.authorKaplan, Ozan
dc.contributor.authorAkgeyik, Emrah
dc.contributor.authorKaynak, Mustafa Sinan
dc.contributor.authorSahin, Selma
dc.date.accessioned2024-08-04T20:10:02Z
dc.date.available2024-08-04T20:10:02Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to determine the acid dissociation constant (pKa) of piroxicam using high performance liquid chromatography (HPLC) and ultraviolet-visible (UV-Vis) spectrophotometry, and to determine the partition coefficient (Log P), distribution coefficient (Log D), and Log kw values of piroxicam using HPLC. Materials and Methods: The HPLC studies were performed on a reversed-phase ACE C18 (150x4.6 mm ID, 5 mu m) column at a flow rate of 1.0 mL min-1. The detector was set to 360 nm. Log D at different pH values (3.0-6.5) was examined with a phosphate buffer (20 mM) and acetonitrile (30:70 v/v) mixture as the mobile phase. For pKa determination, HPLC studies were performed with a mixture of phosphate buffer (20 mM) and methanol within the pH range of 3.50-6.00. Log kw measurements were performed with phosphate buffer (20 mM) and MeOH (from 20:80 v/v to 10:90 v/v) mixtures within the pH range of 3.50-6.00. UV-Vis spectrophotometric pKa measurements were performed at 285 nm wavelength. Results: The pKa value of piroxicam was found to be 5.3 by HPLC and 5.7 by UV-Vis spectrophotometry. Log P of piroxicam was determined as 1.58 in our experimental conditions. Log D values were 1.57, 1.57, 1.44, 1.13, and 0.46 for pH values of 3.17, 3.79, 4.44, 5.42, and 6.56, respectively. Conclusion: In the literature, different Log P (3.1, 2.2, and 0.6) and pKa (6.3 and 4.8) values were reported for piroxicam. The Log P (1.58) and pKa (5.3 and 5.7) values obtained for piroxicam in our study were within the range of the literature values. All these results indicate that different experimental approaches used for the determination of physicochemical properties could provide different values. Although UV spectrophotometry is easy to apply, HPLC is a unique technique for simultaneous determination of pKa, Log D, and Log P values of compounds.en_US
dc.identifier.doi10.4274/tjps.galenos.2019.82335
dc.identifier.endpage541en_US
dc.identifier.issn1304-530X
dc.identifier.issue5en_US
dc.identifier.pmid33177935en_US
dc.identifier.scopus2-s2.0-85094616257en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage535en_US
dc.identifier.trdizinid410948en_US
dc.identifier.urihttps://doi.org/10.4274/tjps.galenos.2019.82335
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/410948
dc.identifier.urihttps://hdl.handle.net/11616/92569
dc.identifier.volume17en_US
dc.identifier.wosWOS:000585327200012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Pharmacists Assocen_US
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPiroxicamen_US
dc.subjectphysicochemical propertiesen_US
dc.subjectpKaen_US
dc.subjectLog Pen_US
dc.subjectLog Den_US
dc.subjectLog kwen_US
dc.titleDetermination of the Physicochemical Properties of Piroxicamen_US
dc.typeArticleen_US

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