Screening of three ERBB4 gene polymorphisms in a group of Turkish schizophrenia patients and controls

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dc.authoridSözen, Mustafa Mert/0000-0002-1672-2206
dc.authoridkartalcı, şükrü/0000-0003-2560-0355
dc.authorwosidSözen, Mustafa Mert/E-7278-2011
dc.authorwosidkartalcı, şükrü/ABI-1106-2020
dc.contributor.authorSozen, Mustafa Mert
dc.contributor.authorKartalci, Sukru
dc.date.accessioned2024-08-04T20:09:48Z
dc.date.available2024-08-04T20:09:48Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The human ERBB4 gene (v-erb-a erithroblastic leukemia viral oncogene homology 4) codes for the ErbB4 receptor protein. One of the ligands of ErbB4 receptor is Neuregulin-1 and it is coded by NRG1 gene which is reported to be a susceptibility gene for schizophrenia. Since ErbB4 receptor is activated by binding of Neuregulin-1, ERBB4 gene is thought to be involved in development of schizophrenia (SZ) as well. Even though several association, expression and animal studies supported this idea and resulted with association between the disease and several single nucleotide polymorphisms (SNP) in the ERBB4 gene, independent studies done in different populations did not replicate that result. In the present study we aimed to get clues about involvement of three ERBB4 SNPs -which were found to be associated with schizophrenia in some other populations- in development of schizophrenia in a group of Turkish patients. Methods: We screened 3 SNPs (rs707284, rs7598440 and rs839523) in a group of Turkish schizophrenia patients and a matched control group from Malatya-Turkey to test the presence of such an association. For SNP genotyping, we used a real-time PCR based method and we evaluated the results with chi-square test. We have analyzed the haplotypes constituted by those three SNPs for multiple locus associations as well as analyzing each for single SNP associations. Results: After SNP genotyping and statistical tests comparing our case and control groups for allele, genotype and haplotype distributions, there was no significant difference between those two groups for three SNPs we screened. Conclusion: We were not able to find a significant evidence for presence of an association between three SNPs located in the ERBB4 gene and schizophrenia in our patients.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [2012/79]en_US
dc.description.sponsorshipThis study was supported by Inonu University Scientific Research Projects Unit (Project number: 2012/79). The Research Projects Unit had no role in the study design, methods, informant recruitment, data analysis, and preparation of the paper. There is no conflict of interest to report concerning this research. We thank all participants in our patient and control groups. We also thank Prof. Dr. Elif Yesilada for providing us laboratory space and equipment.en_US
dc.identifier.doi10.1515/tjb-2015-0036
dc.identifier.endpage471en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84948166788en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage463en_US
dc.identifier.trdizinid236204en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2015-0036
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/236204
dc.identifier.urihttps://hdl.handle.net/11616/92448
dc.identifier.volume40en_US
dc.identifier.wosWOS:000368907400005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAssociationen_US
dc.subjectschizophreniaen_US
dc.subjectERBB4en_US
dc.subjectSNPen_US
dc.subjecthaplotypeen_US
dc.subjectTurkish patientsen_US
dc.titleScreening of three ERBB4 gene polymorphisms in a group of Turkish schizophrenia patients and controlsen_US
dc.typeArticleen_US

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