The effects of phenoxybenzamine on tyrosine hydroxylase (TH) and mRNA level in adrenal medulla of sprague dawley rats

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dc.contributor.authorYĆ¼rekli, Muhittin
dc.date.accessioned2020-09-09T08:29:05Z
dc.date.available2020-09-09T08:29:05Z
dc.date.issued1998
dc.departmentÄ°nƶnĆ¼ Ɯniversitesien_US
dc.descriptionYıl: 1998Cilt: 28Sayı: 1ISSN: 1300-0144 / 1303-6165Sayfa Aralığı: 35 - 39Metin Dili:İngilizceen_US
dc.description.abstractAbstract: The effects of anti hipertensive phenoxybenzamine were investigated on tyrosine hydroxylase (TH) enzyme activity and TH mRNA levels. In the present study 5 months male sprague dawley (SD) rats were used. Phenoxybenzamine was injected i.p as 20 mg/kg which prepared in the 0.9 % NaCI and 5% ethanole. TH activity was measured by detecting of formation of 3H2O as a formation of dopa from 3H-tyrosine by radioisotope technique total adrenal RNA was isolated and hybridized wit 32P labeled cDNA. TH mRNA was assayed by densitometric scanning of the autoradiograms using a densitometer. TH activity and TH mRNA levels were found to be significantly increased by the effcet of phenoxybenzamine (P<0.01).en_US
dc.identifier.citationYƜREKLİ M (1998). The effects of phenoxybenzamine on tyrosine hydroxylase (TH) and mRNA level in adrenal medulla of sprague dawley rats. Turkish Journal of Medical Sciences, 28(1), 35 - 39.en_US
dc.identifier.endpage39en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.startpage35en_US
dc.identifier.trdizinid6248en_US
dc.identifier.urihttps://hdl.handle.net/11616/17996
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/6248
dc.identifier.volume28en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherTurkish Journal of Medical Sciencesen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Ɩğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe effects of phenoxybenzamine on tyrosine hydroxylase (TH) and mRNA level in adrenal medulla of sprague dawley ratsen_US
dc.typeArticleen_US

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