Etiological, clinical, and laboratory evaluation of congenital hypothyroidism and determination of levothyroxine (LT4) dose at treatment interruption in differentiating permanent vs. transient patients

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dc.authoridDundar, Ismail/0000-0003-1468-6405
dc.authoridBuyukavci, Mehmet Akif/0000-0001-6884-1832;
dc.authorwosidDundar, Ismail/ABG-2027-2021
dc.authorwosidBuyukavci, Mehmet Akif/HCH-2615-2022
dc.authorwosidÇiftci, Nurdan/GNM-8116-2022
dc.contributor.authorDundar, Ismail
dc.contributor.authorBuyukavci, Mehmet Akif
dc.contributor.authorCiftci, Nurdan
dc.date.accessioned2024-08-04T20:10:16Z
dc.date.available2024-08-04T20:10:16Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aim: Congenital hypothyroidism (CH) is the most common cause of preventable but irreversible mental retardation in children, although the risk has been widely abolished by national neonatal screening programs. The aim of this study was to determine, (a) the cause of CH, (b) the etiological cause of persistent CH and (c) to investigate the role of laboratory and clinical data in predicting persistent and transient CH. Materials and methods: Patients diagnosed with CH, who started L-thyroxine treatment and were followed up for at least three years were included. Patient data were reviewed retrospectively. Serum thyroid hormones were measured four weeks after discontinuation of therapy at age three or earlier. Cases with a thyroid-stimulating hormone (TSH) value of >10 mIU/mL were accepted as permanent hypothyroidism, while cases with normal TSH values for six months after cessation were accepted as transient hypothyroidism. Results: There were 232 treated cases, of whom 108 (46.6%) were female, and 169 (72.8%) were eventually diagnosed with transient CH. The best cut-off point for predicting permanent status was determined as LT4 cut-off dose >= 1.45 mcg/kg/day. The median (range) duration of L-thyroxine treatment in transient hypothyroid cases was 24 (range: 6-36) months, and treatment was discontinued before the age of three years in 64%. Conclusion: It has been shown that the most common etiologic cause of CH is transient hypothyroidism. The thyroxine dose at the time of discontinuation of treatment and free thyroxine and TSH levels at the time of diagnosis are essential determinants in distinguishing permanent/transient CH.en_US
dc.identifier.doi10.55730/1300-0144.5533
dc.identifier.endpage1871en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid36945978en_US
dc.identifier.scopus2-s2.0-85144507466en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1863en_US
dc.identifier.trdizinid1145650en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5533
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1145650
dc.identifier.urihttps://hdl.handle.net/11616/92689
dc.identifier.volume52en_US
dc.identifier.wosWOS:000906716200015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCongenital hypothyroidismen_US
dc.subjecttransient hypothyroidismen_US
dc.subjectpermanent hypothyroidismen_US
dc.subjectetiologyen_US
dc.titleEtiological, clinical, and laboratory evaluation of congenital hypothyroidism and determination of levothyroxine (LT4) dose at treatment interruption in differentiating permanent vs. transient patientsen_US
dc.typeArticleen_US

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