Effects of misoprostol on the endometrium of ovariectomized rats

dc.authorscopusid8231775000
dc.authorscopusid6602782865
dc.authorscopusid56104637200
dc.authorscopusid7006065717
dc.authorscopusid56720163300
dc.contributor.authorSönmez A.S.
dc.contributor.authorBirincio?lu M.
dc.contributor.authorAydin A.
dc.contributor.authorKiliç E.
dc.contributor.authorŞahin N.
dc.date.accessioned2024-08-04T20:00:53Z
dc.date.available2024-08-04T20:00:53Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMisoprostol (Cytotec, Searle, England), a prostaglandin E1 analogue, is indicated for protection of peptic disease induced by cyclo-oxygenase inhibitors. Since vaginal bleeding was reported during misoprostol use previously, we hypothesized that misoprostol might cause endometrial stimulation. Therefore, we investigated the effects of misoprostol on the endometrium of ovariectomized (OVX) rats to investigate any endometrial changes. Thirty-two, four month-old, parous female Sprague-Dawley rats were used in this study. All rats underwent ovariectomy at the beginning of the study. Sixty days after the ovariectomy six rats were sacrificed to remove the uterus and the remaining 26 rats were divided into three groups. Group I (six rats) was treated with vehicle (1 cc of distilled water orally) for 60 days. Groups II and II (ten rats each) were treated with oral 100 and 200 ?g/day misoprostol, respectively, for 60 days. At the end of the treatment laparotomy was performed and the uteri of all the rats were removed. Histopathologic examination of the endometrium 60 days after ovariectomy revealed endometrial atrophy. But after misoprostol administration a minimal endometrial proliferation was encountered regardless of the dose of misoprostol. The present study demonstrated that misoprostol can cause a proliferation in the endometrium after 60 days of administration. Long term studies are needed to evaluate if this proliferation leads to hyperplasia and cancer, especially in postmenopausal women.en_US
dc.identifier.endpage118en_US
dc.identifier.issn1300-0144
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0034043530en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage115en_US
dc.identifier.trdizinid12642en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/12642
dc.identifier.urihttps://hdl.handle.net/11616/91076
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometriumen_US
dc.subjectMenopauseen_US
dc.subjectMisoprostolen_US
dc.titleEffects of misoprostol on the endometrium of ovariectomized ratsen_US
dc.typeArticleen_US

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